中药抗腺病毒作用的研究进展
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摘要
腺病毒种类繁多且分布广泛,是引起人类呼吸道感染的重要病原之一。腺病毒感染所致的疾病目前没有特效药,而中药具有耐药性低和多靶点作用机制等优势,所以在治疗腺病毒感染方面具有广阔的发展前景。文章从紫草素、黄芪甲苷、肉桂醛、松针油、大青叶提取物和穿心莲内酯磺化物等中药单体及有效成分的抗腺病毒研究,双黄连制剂、热毒宁注射液、喜炎平注射液等中药复方制剂的抗腺病毒研究和部分药物的临床应用等3个方面进行综述,为寻找抗病毒药物提供依据。
Adenoviruses are widely distributed and are one part of the important pathogens causing respiratory infections in humans. There is no specific remedy for adenovirus infection at present. The traditional Chinese medicines have a variety of advantages including low drug resistance and multi-target mechanism and so on, so the Chinese medicines may have a broad prospect in the treatment of adenovirus infection. This review summarized anti-adenovirus research on Chinese medicine monomers and active ingredients such as shikonin, astragaloside, cinnamaldehyde, pine needle oil, folium isatidis extract and andrographolide sulfonate, anti-adenovirus research on Chinese medicine compound Preparation such as Shuanghuanglian Preparation, Reduning Injection, Xiyanping injection and clinical application of some drugs, which provide a basis for the development of novel anti-adenovirus drugs.
Adenoviruses are widely distributed and are one part of the important pathogens causing respiratory infections in humans. There is no specific remedy for adenovirus infection at present. The traditional Chinese medicines have a variety of advantages including low drug resistance and multi-target mechanism and so on, so the Chinese medicines may have a broad prospect in the treatment of adenovirus infection. This review summarized anti-adenovirus research on Chinese medicine monomers and active ingredients such as shikonin, astragaloside, cinnamaldehyde, pine needle oil, folium isatidis extract and andrographolide sulfonate, anti-adenovirus research on Chinese medicine compound Preparation such as Shuanghuanglian Preparation, Reduning Injection, Xiyanping injection and clinical application of some drugs, which provide a basis for the development of novel anti-adenovirus drugs.
引文
[1]王镓,董竞成.浅析中医药防治呼吸道病毒感染的概况.中华中医药杂志,2014,29(1):17-21
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[3]Gao H,Liu L,Qu ZY,et al.Anti-adenovirus activities of shikonin,a component of Chinese herbal medicine in vitro.Biological&Pharmaceutical Bulletin,2011,34(2):197
[4]Shang L,Qu Z,Sun L,et al.AstragalosideⅣinhibits adenovirus replication and apoptosis in A549 cells in vitro.Journal of Pharmacy&Pharmacology,2011,63(5):688-694
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[6]魏晓露,彭成,万峰.广藿香醇体外抗呼吸道病毒作用研究.中药药理与临床,2013,29(1):26-29
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[13]李向峰.儿童型双黄连口服液治疗小儿上呼吸道感72例疗效评价.中国药业,2017,26(17):61-63
[14]冯旰珠,周锋,黄茂,等.热毒宁注射液对腺病毒-3的体外抑制作用.中国新药与临床杂志,2007,26(8):573-577
[15]刘青.热毒宁注射液治疗小儿咽结合膜热的疗效与进展.中国处方药,2017,15(6):21-23
[16]张秀英,王雪峰,王思源,等.喜炎平注射液对腺病毒感染Hep-2细胞Bcl-2/Bax蛋白表达的影响.中国中西医结合儿科学,2017,9(2):96-99
[17]侯天禄,詹恬恬,奚安,等.外感清热解毒方抗呼吸道病毒活性的体外实验研究.世界中医药,2016,11(10):2089-2093
[18]付萍,杨铭,陈颖丽,等.抗病毒滴丸抗病毒作用的实验研究.中国实验方剂学杂志,2007,13(6):46-48
[19]何晓静,张岩,肇丽梅.清热合剂体外抗腺病毒Ⅲ型作用.中国现代应用药学,2008,25(2):83-85
[20]王跃溪,刘玉祁,王丽颖,等.中医药标准化发展迎来新的机遇与挑战.中华中医药杂志,2018,33(6):2252-2254
[21]常凯,付文娇.中医药标准推广应用策略研究.中华中医药杂志,2017,32(3):1156-1158
[22]甄兴刚.小儿肺热咳喘口服液与双黄连口服液治疗小儿病毒性上呼吸道感染的疗效比较.中国实用医药,2018,13(1):107-109
[23]陶景芬,张滔,时晓亚,等.热毒宁与喜炎平注射液治疗急性上呼吸道感染的Meta分析.西部中医药,2015,28(2):63-66
[24]罗李娜,陈更新.关于中药新药开发现代化的几点思考.中华中医药杂志,2017,33(11):4798-4800
[25]管政,宋亚凤,李巍,等.从新时代患者视角思考中医药研究.中华中医药杂志,2018,33(10):4274-4277
[26]张志国,杨磊,张琴,等.中药炮制的现状及出现的新问题.中华中医药杂志,2018,33(8):3233-3238
[2]Liu L,Wei F,Qu Z,et al.The antiadenovirus activities of cinnamaldehyde in vitro.Laboratory Medicine,2009,40(11):669-674
[3]Gao H,Liu L,Qu ZY,et al.Anti-adenovirus activities of shikonin,a component of Chinese herbal medicine in vitro.Biological&Pharmaceutical Bulletin,2011,34(2):197
[4]Shang L,Qu Z,Sun L,et al.AstragalosideⅣinhibits adenovirus replication and apoptosis in A549 cells in vitro.Journal of Pharmacy&Pharmacology,2011,63(5):688-694
[5]魏凤香,商蕾,曲章义,等.松针油体外抗腺病毒作用研究.中草药,2007,38(7):1059-1062
[6]魏晓露,彭成,万峰.广藿香醇体外抗呼吸道病毒作用研究.中药药理与临床,2013,29(1):26-29
[7]邓幼平.大青叶提取物抗呼吸道病毒作用的药效学研究.武汉:武汉大学,2013
[8]杨艳,彭璇,朱薿,等.荔枝核黄酮类化合物的体外抗腺病毒作用.武汉大学学报(医学版),2014,35(1):41-45
[9]平静,王思源,谢宁,等.穿心莲内酯磺化物体外抗腺病毒药效学研究.中国实验方剂学杂志,2012,18(21):175-179
[10]李曼.甘草的临床应用研究.中华现代临床医学杂志,2008,6(8):724-725
[11]李春娜,刘洋洋,李鹏收,等.中药复方双黄连剂型研究.中国中医药科技,2015,22(1):115-117
[12]沈斯瑶,刘军辉,田艳茹,等.双黄连片对小鼠流感病毒和腺病毒感染的保护作用.中国实用医药,2008,3(15):50-52
[13]李向峰.儿童型双黄连口服液治疗小儿上呼吸道感72例疗效评价.中国药业,2017,26(17):61-63
[14]冯旰珠,周锋,黄茂,等.热毒宁注射液对腺病毒-3的体外抑制作用.中国新药与临床杂志,2007,26(8):573-577
[15]刘青.热毒宁注射液治疗小儿咽结合膜热的疗效与进展.中国处方药,2017,15(6):21-23
[16]张秀英,王雪峰,王思源,等.喜炎平注射液对腺病毒感染Hep-2细胞Bcl-2/Bax蛋白表达的影响.中国中西医结合儿科学,2017,9(2):96-99
[17]侯天禄,詹恬恬,奚安,等.外感清热解毒方抗呼吸道病毒活性的体外实验研究.世界中医药,2016,11(10):2089-2093
[18]付萍,杨铭,陈颖丽,等.抗病毒滴丸抗病毒作用的实验研究.中国实验方剂学杂志,2007,13(6):46-48
[19]何晓静,张岩,肇丽梅.清热合剂体外抗腺病毒Ⅲ型作用.中国现代应用药学,2008,25(2):83-85
[20]王跃溪,刘玉祁,王丽颖,等.中医药标准化发展迎来新的机遇与挑战.中华中医药杂志,2018,33(6):2252-2254
[21]常凯,付文娇.中医药标准推广应用策略研究.中华中医药杂志,2017,32(3):1156-1158
[22]甄兴刚.小儿肺热咳喘口服液与双黄连口服液治疗小儿病毒性上呼吸道感染的疗效比较.中国实用医药,2018,13(1):107-109
[23]陶景芬,张滔,时晓亚,等.热毒宁与喜炎平注射液治疗急性上呼吸道感染的Meta分析.西部中医药,2015,28(2):63-66
[24]罗李娜,陈更新.关于中药新药开发现代化的几点思考.中华中医药杂志,2017,33(11):4798-4800
[25]管政,宋亚凤,李巍,等.从新时代患者视角思考中医药研究.中华中医药杂志,2018,33(10):4274-4277
[26]张志国,杨磊,张琴,等.中药炮制的现状及出现的新问题.中华中医药杂志,2018,33(8):3233-3238