我院2017年272例药品不良反应的原因分析和对策研究
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摘要
目的了解我院药品不良反应(ADR)发生的规律和特点,分析原因,探讨对策,为临床合理用药提供依据。方法采用回顾性分析方法,对我院2017年上报的272例ADR报告内容进行统计分析。结果272例ADR报告中,男性142例(52.21%),女性130例(47.79%),60岁以上的老年患者ADR发生率较高(38.24%);引发ADR的药物种类以抗感染药物最高,占26.84%,抗肿瘤药位居第二,为16.18%;ADR涉及的药物给药途径中静脉给药所占比例居首位,为72.06%,其次为口服;ADR以皮肤及附件系统损害最多见(38.24%),其次是消化系统症状(19.12%),如恶心、呕吐、腹胀、腹泻等。结论人口老龄化和药物滥用等导致ADR更易发生,我们需要不断完善现有的药品法律法规,优化ADR上报体系,提高药学服务水平,促进合理用药。
Objective To understand the regularity and characteristics of adverse drug reactions(ADR)in our hospital, analyze the causes,and explore countermeasures to provide a basis for clinical rational drug use. Methods A retrospective analysis method was used to analyze the contents of 272 ADR reports reported by our hospital in 2017.Results Of the 272 ADR reports,142(52.21%)were males and 130(47.79%)were females.The incidence of ADR was higher in elderly patients over 60 years old(38.24%);The types of drugs that cause ADR were the highest,accounting for 26.84%,the anti-tumor drug ranked second with 16.18%;the proportion of intravenous drug administration in ADR was 72.06%,followed by oral administration;ADR was most common in skin and accessory system(38.24%),followed by digestive symptoms(19.12%),such as nausea,vomiting,bloating,diarrhea,etc. Conclusion ADR is more likely to occur due to population aging and drug abuse.We need to constantly improve existing drug laws and regulations,optimize the ADR reporting system,improve the level of pharmaceutical services,and promote rational drug use.
Objective To understand the regularity and characteristics of adverse drug reactions(ADR)in our hospital, analyze the causes,and explore countermeasures to provide a basis for clinical rational drug use. Methods A retrospective analysis method was used to analyze the contents of 272 ADR reports reported by our hospital in 2017.Results Of the 272 ADR reports,142(52.21%)were males and 130(47.79%)were females.The incidence of ADR was higher in elderly patients over 60 years old(38.24%);The types of drugs that cause ADR were the highest,accounting for 26.84%,the anti-tumor drug ranked second with 16.18%;the proportion of intravenous drug administration in ADR was 72.06%,followed by oral administration;ADR was most common in skin and accessory system(38.24%),followed by digestive symptoms(19.12%),such as nausea,vomiting,bloating,diarrhea,etc. Conclusion ADR is more likely to occur due to population aging and drug abuse.We need to constantly improve existing drug laws and regulations,optimize the ADR reporting system,improve the level of pharmaceutical services,and promote rational drug use.
引文
[1]王雁群,相会欣,刘丽莉,等.医药商品学[M].北京:中国医药科技出版社,2017.
[2]我国去年底60岁以上老人占17.3%到2050年将近5亿.[DB/OL].(2018-02-26)http://news.sina.com.cn/c/2018-02-26/doc-ifyrvnsw9319158.shtml
[3]吴建伟.老年人合理用药及用药安全的探讨[J].临床合理用药,2015,8(3C):31-32
[4]方松柏,余秋强,尹汉华,等.106例药品不良反应报告分析[J].今日药学,2017,27(12):841-844.
[5]高翔,陈玲,邓蓉蓉,等.过度静脉输液的现状、危害及管控措施[J].药学进展,2016,40(2):141-144.
[6]徐培红,干荣富.分级管理常态化下的抗感染药物使用现状分析[J].国外医药抗生素分册,2016,37(3):99-106.
[7]刘敬弢,张艳华.抗肿瘤治疗药物监测与合理应用研究进展[J].中国新药杂志,2015,24(16):1916-1920.
[8]巩莉.靶向抗肿瘤药物的不良反应及药学监护[J].山西药学杂志,2017,46(3):347-348.
[2]我国去年底60岁以上老人占17.3%到2050年将近5亿.[DB/OL].(2018-02-26)http://news.sina.com.cn/c/2018-02-26/doc-ifyrvnsw9319158.shtml
[3]吴建伟.老年人合理用药及用药安全的探讨[J].临床合理用药,2015,8(3C):31-32
[4]方松柏,余秋强,尹汉华,等.106例药品不良反应报告分析[J].今日药学,2017,27(12):841-844.
[5]高翔,陈玲,邓蓉蓉,等.过度静脉输液的现状、危害及管控措施[J].药学进展,2016,40(2):141-144.
[6]徐培红,干荣富.分级管理常态化下的抗感染药物使用现状分析[J].国外医药抗生素分册,2016,37(3):99-106.
[7]刘敬弢,张艳华.抗肿瘤治疗药物监测与合理应用研究进展[J].中国新药杂志,2015,24(16):1916-1920.
[8]巩莉.靶向抗肿瘤药物的不良反应及药学监护[J].山西药学杂志,2017,46(3):347-348.