鲁南地区340例泌尿系结石成分分析
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摘要
目的:探讨分析鲁南地区泌尿系结石患者的结石成分,为当地的临床防治提供依据。方法:选取鲁南地区泌尿系结石标本340例,采用红外光谱法确定其结石成分,并结合临床资料进行分析。结果:340例患者中,年龄12～89岁,平均(53.36±25.46)岁,高发年龄为45～59岁;男女比例为2.271;上下尿路结石比例为7.501;单一成分结石和混合成分结石分别占结石成分总数的52.65%和47.35%;草酸钙结石检出率最高,为255例(75.00%),其次为尿酸类结石121例(35.59%)和感染性结石110例(32.35%);草酸钙结石、尿酸类结石分别于青年组(19～44岁)、老年组(≥60岁)检出率最高;上尿路草酸钙结石检出率高于下尿路,下尿路尿酸类结石检出率高于上尿路。结论:鲁南地区泌尿系结石成分以草酸钙为主,存在着年龄、性别、发病部位及地域的差异,这对该地区的临床防治具有重要意义。
Objective:To explore the status of urinary calculi in patients from Lunan area,and to provide the evidence for local clinical prevention and treatment.Method:A total of 340 samples of urinary calculi from Lunan area were collected.The composition of urinary calculi was detected by infrared spectroscopy and the clinical data were also analyzed.Result:In 340 cases of stone samples,the age was 12-89 years old,with the mean age of(53.36±25.46)years old,and the age of high incidence was 45-59 years old.The male to female ratio was 2.271 and the ratio of upper and lower urinary calculi was 7.501.Pure stones accounted for 52.65% and mixed stones accounted for 47.35%.In the composition of various urinary calculi,calcium oxalate stones were the most in 255 cases(75.00%),followed by uric acid stones in 121 cases(35.59%)and infection stones in 110 cases(32.35%).The highest detection of calcium oxalate stones and uric acid stones were respectively found in the young group(19-44 years old)and the elderly group(over 60 years old).The detection rate of calcium oxalate stones in the upper urinary tract was higher than that in the lower urinary tract,and the detection rate of uric acid stones in the lower urinary tract was higher than that in the upper urinary tract.Conclusion:The urinary calculi in Lunan area is dominated by calcium oxalate,and there is difference in age,gender,incidence site and area.This is of great significance for local clinical control.
Objective:To explore the status of urinary calculi in patients from Lunan area,and to provide the evidence for local clinical prevention and treatment.Method:A total of 340 samples of urinary calculi from Lunan area were collected.The composition of urinary calculi was detected by infrared spectroscopy and the clinical data were also analyzed.Result:In 340 cases of stone samples,the age was 12-89 years old,with the mean age of(53.36±25.46)years old,and the age of high incidence was 45-59 years old.The male to female ratio was 2.271 and the ratio of upper and lower urinary calculi was 7.501.Pure stones accounted for 52.65% and mixed stones accounted for 47.35%.In the composition of various urinary calculi,calcium oxalate stones were the most in 255 cases(75.00%),followed by uric acid stones in 121 cases(35.59%)and infection stones in 110 cases(32.35%).The highest detection of calcium oxalate stones and uric acid stones were respectively found in the young group(19-44 years old)and the elderly group(over 60 years old).The detection rate of calcium oxalate stones in the upper urinary tract was higher than that in the lower urinary tract,and the detection rate of uric acid stones in the lower urinary tract was higher than that in the upper urinary tract.Conclusion:The urinary calculi in Lunan area is dominated by calcium oxalate,and there is difference in age,gender,incidence site and area.This is of great significance for local clinical control.
引文
1 Romero V,Akpinar H,Assimos D G.Kidney stones:a global picture of prevalence,incidence,and associated risk factors[J].Rev Urol,2010,12(2-3):e86-e96.
2叶章群,周辉.泌尿系结石基础研究及临床新进展[J].中华泌尿外科杂志,2017,38(9):644-649.
3 Khan A.Prevalence,pathophysiological mechanisms and factors affecting urolithiasis[J].Int Urol Nephrol,2018,50(5):799-806.
4文焰林,王安果,张宗平,等.南充地区泌尿系结石成分分析及其与国内各地结石成分的差异[J].中华腔镜泌尿外科杂志(电子版),2014,8(6):421-427.
5 Alatab S,Pourmand G,El Howairis Mel F,et al.National Profiles of Urinary Calculi:a Comparison Between Developing and Developed Worlds[J].Iran J Kidney Dis,2016,10(2):51-61.
6那彦群,叶章群,孙颖浩,等.中国泌尿外科疾病诊断治疗指南[M].北京:人民卫生出版社,2014:134.
7李延军,仝华,阳东荣,等.泌尿系结石2 379例成分成因分析及代谢评估[J].实用医技杂志,2016,23(6):599-601.
8徐勋,赵振华,石明,等.1 168例泌尿系结石患者结石成分分析及其饮食预防指导[J].临床泌尿外科杂志,2014,29(8):694-696.
9 Jing Z,GuoZeng W,Ning J,et al.Analysis of urinary calculi composition by infrared spectroscopy:aprospective study of 625patients in eastern China[J].Urol Res,2010,38(2):111-115.
10 Wu W,Yang B,Ou L,et al.Urinary stone analysis on 12 846patients:a report from a single center in China[J].Urolithiasis,2014,42(2):39-43.
11陈卫红,朱建国,刘军,等.红外光谱分析泌尿系结石成分207例[J].中华腔镜泌尿外科杂志(电子版),2011,5(5):382-385.
12肖博,李建兴.2017年欧洲泌尿外科学会(EAUl7)泌尿系结石研究热点[J].中华泌尿外科杂志,2017,38(5):330-331.
13 Thomas B,To11ey D.Concurrent urinary tract infection and stone disease:pathogenesis,diagnosis and management[J].Nat Clin Pract Urol,2008,5(12):668-675.
14吴阶平.吴阶平泌尿外科学[M].济南:山东科学技术出版社,2004:731-732.
15 Barbera M,Tsirgiotis A,Barbera M,et al.The importance of citrates in treatment and prophylaxis of calcium oxalate urinary stones[J].Arch Ital Urol Androl,2016,88(4):343-344.
16颜赟坤,柳健军,郑土康,等.粤西湛江地区285例泌尿系结石成分分析[J].中国医药科学,2018,8(2):176-179.
17 Randall A.The origin and growth of renal calculi[J].Ann Surg,1937,105(6):1009-1027.
18章璟,王国增,姜宁,等.尿酸结石红外光谱成分分析[J].实用医学杂志,2010,26(19):3576-3578.
19 Alaya A,Hellara I,Belgith M,et al.Stone composition in the central coast Tunisian population[J].Prog Urol,2012,22(15):938-944.
20 Daudon M,DoréJ C,Jungers P,et al.Changes in stone composition according to age and gender of patients:a multivariate epidemiological approach[J].Urol Res,2004,32(3):241-247.
21陈增谋,梁荣杰,陈芬波,等.桂东地区258例泌尿系结石患者的结石成分与相关危险因素分析[J].临床泌尿外科杂志,2017,32(4):286-289.
2叶章群,周辉.泌尿系结石基础研究及临床新进展[J].中华泌尿外科杂志,2017,38(9):644-649.
3 Khan A.Prevalence,pathophysiological mechanisms and factors affecting urolithiasis[J].Int Urol Nephrol,2018,50(5):799-806.
4文焰林,王安果,张宗平,等.南充地区泌尿系结石成分分析及其与国内各地结石成分的差异[J].中华腔镜泌尿外科杂志(电子版),2014,8(6):421-427.
5 Alatab S,Pourmand G,El Howairis Mel F,et al.National Profiles of Urinary Calculi:a Comparison Between Developing and Developed Worlds[J].Iran J Kidney Dis,2016,10(2):51-61.
6那彦群,叶章群,孙颖浩,等.中国泌尿外科疾病诊断治疗指南[M].北京:人民卫生出版社,2014:134.
7李延军,仝华,阳东荣,等.泌尿系结石2 379例成分成因分析及代谢评估[J].实用医技杂志,2016,23(6):599-601.
8徐勋,赵振华,石明,等.1 168例泌尿系结石患者结石成分分析及其饮食预防指导[J].临床泌尿外科杂志,2014,29(8):694-696.
9 Jing Z,GuoZeng W,Ning J,et al.Analysis of urinary calculi composition by infrared spectroscopy:aprospective study of 625patients in eastern China[J].Urol Res,2010,38(2):111-115.
10 Wu W,Yang B,Ou L,et al.Urinary stone analysis on 12 846patients:a report from a single center in China[J].Urolithiasis,2014,42(2):39-43.
11陈卫红,朱建国,刘军,等.红外光谱分析泌尿系结石成分207例[J].中华腔镜泌尿外科杂志(电子版),2011,5(5):382-385.
12肖博,李建兴.2017年欧洲泌尿外科学会(EAUl7)泌尿系结石研究热点[J].中华泌尿外科杂志,2017,38(5):330-331.
13 Thomas B,To11ey D.Concurrent urinary tract infection and stone disease:pathogenesis,diagnosis and management[J].Nat Clin Pract Urol,2008,5(12):668-675.
14吴阶平.吴阶平泌尿外科学[M].济南:山东科学技术出版社,2004:731-732.
15 Barbera M,Tsirgiotis A,Barbera M,et al.The importance of citrates in treatment and prophylaxis of calcium oxalate urinary stones[J].Arch Ital Urol Androl,2016,88(4):343-344.
16颜赟坤,柳健军,郑土康,等.粤西湛江地区285例泌尿系结石成分分析[J].中国医药科学,2018,8(2):176-179.
17 Randall A.The origin and growth of renal calculi[J].Ann Surg,1937,105(6):1009-1027.
18章璟,王国增,姜宁,等.尿酸结石红外光谱成分分析[J].实用医学杂志,2010,26(19):3576-3578.
19 Alaya A,Hellara I,Belgith M,et al.Stone composition in the central coast Tunisian population[J].Prog Urol,2012,22(15):938-944.
20 Daudon M,DoréJ C,Jungers P,et al.Changes in stone composition according to age and gender of patients:a multivariate epidemiological approach[J].Urol Res,2004,32(3):241-247.
21陈增谋,梁荣杰,陈芬波,等.桂东地区258例泌尿系结石患者的结石成分与相关危险因素分析[J].临床泌尿外科杂志,2017,32(4):286-289.