阵发性腰痛2年 双下肢疼痛2个月
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摘要
<正>患者女性,44岁,公务员,因阵发性腰痛2年、双下肢疼痛2个月,于2018年6月25日入院。患者2年前(2016年9月)无明显诱因出现阵发性腰痛,疼痛剧烈,均发生于夜间睡眠期,发作频率2～3次/晚,持续时间约30 min,起床活动后可改善,视觉模拟评分(VAS)10分,不伴头痛、恶心呕吐、心悸气短,无运动障碍和感觉异常,当地医院诊断为"骶髂关
引文
[1]Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer J,Trimmer JS, Shrager P, Peles E. Caspr2, a new member of theneurexin superfamily, is localized at the juxtaparanodes ofmyelinated axons and associates with K+channels[J]. Neuron,1999, 24:1037-1047.
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[3]Vincent A. Autoimmune channelopathies:John Newsom-Davis'swork and legacy. A summary of the Newsom-Davis MemorialLecture 2008[J]. J Neuroimmunol, 2008, 201:245-249.
[4]Arimura K, Sonoda Y, Watanabe O, Nagado T, Kurono A,Tomimitsu H, Otsuka R, Kameyama M, Osame M. Isaacs'syndrome as a potassium channelopathy of the nerve[J].Muscle Nerve Suppl, 2002, 11:S55-58.
[5]Gutmann L, Libell D, Gutmann L. When is myokymianeuromyotonia[J]? Muscle Nerve, 2001, 24:151-153.
[6]Josephs KA, Silber MH, Fealey RD, Nippoldt TB, Auger RG,Vernino S. Neurophysiologic studies in Morvan syndrome[J]. JClin Neurophysiol, 2004, 21:440-445.
[7]Strauss KA, Puffenberger EG, Huentelman MJ, Gottlieb S,Dobrin SE, Parod JM, Stephan DA, Morton DH. Recessivesymptomatic focal epilepsy and mutant contactin-associatedprotein-like 2[J]. N Engl J Med, 2006, 354:1370-1377.
[8]Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitisand antibodies to synaptic and neuronal cell surface proteins[J]. Neurology, 2011, 77:179-189.
[9]Nosadini M, Mohammad SS, Ramanathan S, Brilot F, Dale RC.Immune therapy in autoimmune encephalitis:a systematicreview[J]. Expert Rev Neurother, 2015, 15:1391-1419.
[10]Ge XY, Yang HN, Jia GY, Wang CL. Clinical analysis of 17cases of LGI1 limbic encephalitis[J]. Zhongguo Shen Jing JingShen Ji Bing Za Zhi, 2018, 44:201-205.[葛晓燕,杨洪娜,贾国勇,王翠兰.抗LGI1抗体相关边缘性脑炎17例临床分析[J].中国神经精神疾病杂志, 2018, 44:201-205.]
[11]Klein CJ, Lennon VA, Aston PA, McKeon A, Pittock SJ.Chronic pain as a manifestation of potassium channel-complexautoimmunity[J]. Neurology, 2012, 79:1136-1144.
[12]Zhang L, Lu Q, Guan HZ, Mei JH, Ren HT, Liu MS, Peng B,Cui LY. A Chinese female Morvan patient with LGI1 andCASPR2 antibodies:a case report[J]. BMC Neurol, 2016, 16:37.
[13]Sunwoo JS, Lee ST, Byun JI, Moon J, Shin JW, Jeong DE, LeeGH, Jeong SH, Shin YW, Jung KH, Lee DY, Jeon D, Jung KY,Kim M, Lee SK, Chu K. Clinical manifestations of patients withCASPR2 antibodies[J]. J Neuroimmunol, 2015, 281:17-22.
[14]Chen B, Niu ST, Zhang JY, Wang XG, Chen N, Pan H, RenHT, Zhao XB, Zhang ZQ. Peripheral neuropathy with positiveCaspr2 antibody:a case report[J]. Zhonghua Shen Jing Ke ZaZhi, 2016, 49:644-646.[陈彬,牛松涛,张佳玥,王新高,陈娜,潘华,任海涛,赵晓斌,张在强.以周围神经病首发的接触蛋白相关蛋白-2抗体阳性患者一例[J].中华神经科杂志, 2016,49:644-646.]
[15]Zhu WJ, Wu LY, Li JY, Fu Y, Wang QQ, Jia JP. A case ofspinal nerve root lesion associated with positive Caspr2 antibody[J]. Zhonghua Shen Jing Ke Za Zhi, 2016, 49:722-723.[朱文佳,武力勇,李洁颖,付月,王欠欠,贾建平.接触蛋白相关样蛋白2抗体阳性相关的脊髓神经根病变一例[J].中华神经科杂志, 2016, 49:722-723.]
[2]Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P,Zuliani L, Peles E, Buckley C, Lang B, Vincent A. Antibodiesto Kv1 potassium channel-complex proteins leucine-rich, gliomainactivated 1 protein and contactin-associated protein-2 inlimbic encephalitis, Morvan's syndrome and acquiredneuromyotonia[J]. Brain, 2010, 133:2734-2748.
[3]Vincent A. Autoimmune channelopathies:John Newsom-Davis'swork and legacy. A summary of the Newsom-Davis MemorialLecture 2008[J]. J Neuroimmunol, 2008, 201:245-249.
[4]Arimura K, Sonoda Y, Watanabe O, Nagado T, Kurono A,Tomimitsu H, Otsuka R, Kameyama M, Osame M. Isaacs'syndrome as a potassium channelopathy of the nerve[J].Muscle Nerve Suppl, 2002, 11:S55-58.
[5]Gutmann L, Libell D, Gutmann L. When is myokymianeuromyotonia[J]? Muscle Nerve, 2001, 24:151-153.
[6]Josephs KA, Silber MH, Fealey RD, Nippoldt TB, Auger RG,Vernino S. Neurophysiologic studies in Morvan syndrome[J]. JClin Neurophysiol, 2004, 21:440-445.
[7]Strauss KA, Puffenberger EG, Huentelman MJ, Gottlieb S,Dobrin SE, Parod JM, Stephan DA, Morton DH. Recessivesymptomatic focal epilepsy and mutant contactin-associatedprotein-like 2[J]. N Engl J Med, 2006, 354:1370-1377.
[8]Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitisand antibodies to synaptic and neuronal cell surface proteins[J]. Neurology, 2011, 77:179-189.
[9]Nosadini M, Mohammad SS, Ramanathan S, Brilot F, Dale RC.Immune therapy in autoimmune encephalitis:a systematicreview[J]. Expert Rev Neurother, 2015, 15:1391-1419.
[10]Ge XY, Yang HN, Jia GY, Wang CL. Clinical analysis of 17cases of LGI1 limbic encephalitis[J]. Zhongguo Shen Jing JingShen Ji Bing Za Zhi, 2018, 44:201-205.[葛晓燕,杨洪娜,贾国勇,王翠兰.抗LGI1抗体相关边缘性脑炎17例临床分析[J].中国神经精神疾病杂志, 2018, 44:201-205.]
[11]Klein CJ, Lennon VA, Aston PA, McKeon A, Pittock SJ.Chronic pain as a manifestation of potassium channel-complexautoimmunity[J]. Neurology, 2012, 79:1136-1144.
[12]Zhang L, Lu Q, Guan HZ, Mei JH, Ren HT, Liu MS, Peng B,Cui LY. A Chinese female Morvan patient with LGI1 andCASPR2 antibodies:a case report[J]. BMC Neurol, 2016, 16:37.
[13]Sunwoo JS, Lee ST, Byun JI, Moon J, Shin JW, Jeong DE, LeeGH, Jeong SH, Shin YW, Jung KH, Lee DY, Jeon D, Jung KY,Kim M, Lee SK, Chu K. Clinical manifestations of patients withCASPR2 antibodies[J]. J Neuroimmunol, 2015, 281:17-22.
[14]Chen B, Niu ST, Zhang JY, Wang XG, Chen N, Pan H, RenHT, Zhao XB, Zhang ZQ. Peripheral neuropathy with positiveCaspr2 antibody:a case report[J]. Zhonghua Shen Jing Ke ZaZhi, 2016, 49:644-646.[陈彬,牛松涛,张佳玥,王新高,陈娜,潘华,任海涛,赵晓斌,张在强.以周围神经病首发的接触蛋白相关蛋白-2抗体阳性患者一例[J].中华神经科杂志, 2016,49:644-646.]
[15]Zhu WJ, Wu LY, Li JY, Fu Y, Wang QQ, Jia JP. A case ofspinal nerve root lesion associated with positive Caspr2 antibody[J]. Zhonghua Shen Jing Ke Za Zhi, 2016, 49:722-723.[朱文佳,武力勇,李洁颖,付月,王欠欠,贾建平.接触蛋白相关样蛋白2抗体阳性相关的脊髓神经根病变一例[J].中华神经科杂志, 2016, 49:722-723.]