红花注射液联合辛伐他汀对急性心肌梗死患者的临床疗效
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摘要
目的探讨红花注射液联合辛伐他汀对急性心肌梗死患者的临床疗效。方法 82例患者随机分为对照组(40例)和观察组(42例),对照组给予辛伐他汀,观察组给予红花注射液联合辛伐他汀,疗程4周。然后,检测总有效率,实验室指标(cTnI、CK-MB、LVEF),凝血功能指标(APTT、PT、FIB),血清VEGF、bFGF、ESM-1表达,不良心血管事件、不良反应发生率变化。结果与对照组比较,观察组总有效率、LVEF、APTT、PT及VEGF、bFGF表达显著升高(P<0.05),cTnI、CK-MB、FIB、ESM-1表达、不良心血管事件发生率显著降低(P<0.05)。2组不良反应发生率无显著差异(P>0.05)。结论红花注射液联合辛伐他汀对急性心肌梗死患者临床疗效良好,其机制可能与调节血清VEGF、bFGF、ESM-1表达有关。
AIM To explore the clinical effects of Honghua Injection combined with simvastatin on acute myocardial infarction patients.METHODS Eighty-two patients were randomly divided into control group(n=40) for 4-week administration of simvastatin, and observation group(n=42) for 4-week administration of Honghua Injection combined with simvastatin. Subsequently, the changes in total effective rate, laboratory indices(cTnI, CK-MB, LVEF), coagulation function indices(APTT, PT, FIB), serum expressions of VEGF, bFGF and ESM-1, occurrence rates of adverse cardiovascular events and adverse reactions were detected.RESULTS Compared with the control group, the observation group demonstrated markedly increased total effective rate, LVEF, APTT, PT, expressions of VEGF and bFGF(P<0.05), obviously decreased cTnI, CK-MB, FIB, expression of ESM-1, occurrance rate of adverse cardiovascular events(P<0.05). No significant difference in occurrence rate of adverse reactions between the two groups was observed(P>0.05). CONCLUSION For the acute myocardial infarction patients, Honghua Injection combined with simvastatin exhibits good clinical efficacy, whose mechanisms may be related to the regulation of serum VEGF, bFGF and ESM-1 expressions.
AIM To explore the clinical effects of Honghua Injection combined with simvastatin on acute myocardial infarction patients.METHODS Eighty-two patients were randomly divided into control group(n=40) for 4-week administration of simvastatin, and observation group(n=42) for 4-week administration of Honghua Injection combined with simvastatin. Subsequently, the changes in total effective rate, laboratory indices(cTnI, CK-MB, LVEF), coagulation function indices(APTT, PT, FIB), serum expressions of VEGF, bFGF and ESM-1, occurrence rates of adverse cardiovascular events and adverse reactions were detected.RESULTS Compared with the control group, the observation group demonstrated markedly increased total effective rate, LVEF, APTT, PT, expressions of VEGF and bFGF(P<0.05), obviously decreased cTnI, CK-MB, FIB, expression of ESM-1, occurrance rate of adverse cardiovascular events(P<0.05). No significant difference in occurrence rate of adverse reactions between the two groups was observed(P>0.05). CONCLUSION For the acute myocardial infarction patients, Honghua Injection combined with simvastatin exhibits good clinical efficacy, whose mechanisms may be related to the regulation of serum VEGF, bFGF and ESM-1 expressions.
引文
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[2] 王福华,郭靖涛,周江,等. 急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入治疗前后血清血管内皮生长因子及高敏C反应蛋白水平变化与术后再狭窄[J]. 临床荟萃,2014,29(11):1217-1221.
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[5] 薄云,李晓燕,张红明,等. 红花注射液对急性心肌梗死动物模型疗效研究[J]. 中华临床医师杂志(电子版),2011,5(3):863-865.
[6] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 急性ST段抬高型心肌梗死诊断和治疗指南[J]. 中华心血管病杂志,2015,43(5):380-393.
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[9] ?apczuk-Romańska J, Wajda A, Pius-Sadowska E, et al. Effects of simvastatin on nuclear receptors, drug metabolizing enzymes and transporters expression in human umbilical vein endothelial cells[J]. Pharmacol Rep, 2018, 70(5): 875-880.
[10] 赵文萃,张艳萍,房颖. 辛伐他汀治疗急性心肌梗死的作用机制研究[J]. 中国药房,2015,26(6):763-766.
[11] 李璐璐,李银花,刘梅颜. 中西医结合治疗急性心肌梗死的研究进展[J]. 中国循证心血管医学杂志,2016,8(1):115-117.
[12] 赵剑锋,刘静,郭颖,等. 红花注射液化学成分及其活性研究[J]. 中国中药杂志,2014,39(16):3102-3106.
[13] 陈培栋,房利勤. 红花注射液和注射用红花黄色素药理作用研究[J]. 世界中医药,2016,11(2):308-310.
[14] 宋世辉,张汝仙,刘明辉,等. 红花注射液对急性心肌梗死大鼠心功能的影响研究[J]. 现代中西医结合杂志,2017,26(10):1043-1045.
[15] 朱岩峰,罗海明,邓中龙,等. 红花注射液对急性冠状动脉综合征患者血小板糖蛋白Ⅱb/Ⅲa受体影响的随机对照研究[J]. 中西医结合学报,2012,10(3):318-323.
[16] Oliveira A L A, Scheffer J P, Markoski M, et al. Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs[J]. Acta Cir Bras, 2018, 33(4): 386-395.
[17] Aljakna A, Fracasso T, Sabatasso S. Molecular tissue changes in early myocardial ischemia: from pathophysiology to the identification of new diagnostic markers[J]. Int J Legal Med, 2018, 132(2): 425-438.
[18] Qiu C R, Fu Q, Sui J, et al. Serum endothelial cell-specific molecule 1 (endocan) levels in patients with acute myocardial infarction and its clinical significance[J]. Angiology, 2017, 68(4): 354-359.
[2] 王福华,郭靖涛,周江,等. 急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入治疗前后血清血管内皮生长因子及高敏C反应蛋白水平变化与术后再狭窄[J]. 临床荟萃,2014,29(11):1217-1221.
[3] Qiu C, Sui J, Zhang Q, et al. Relationship of endothelial cell-specific molecule 1 level in stress hyperglycemia patients with acute ST-segment elevation myocardial infarction: a pilot study[J]. Angiology, 2015, 67(9): 829-834.
[4] 朱尧,夏伟,刘溦溦,等. 中医药论治急性心肌梗死的研究进展[J]. 中国中医急症,2015,24(6):1029-1032.
[5] 薄云,李晓燕,张红明,等. 红花注射液对急性心肌梗死动物模型疗效研究[J]. 中华临床医师杂志(电子版),2011,5(3):863-865.
[6] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 急性ST段抬高型心肌梗死诊断和治疗指南[J]. 中华心血管病杂志,2015,43(5):380-393.
[7] 国家中医药管理局.中药新药临床研究指导原则[S]. 北京:中国医药科技出版社, 2002: 68-73.
[8] 陈丽君,袁慧,赵臻. 1991年—2013年心血管病流行病学特征分析[J]. 中国病案,2015,16(3):54-56.
[9] ?apczuk-Romańska J, Wajda A, Pius-Sadowska E, et al. Effects of simvastatin on nuclear receptors, drug metabolizing enzymes and transporters expression in human umbilical vein endothelial cells[J]. Pharmacol Rep, 2018, 70(5): 875-880.
[10] 赵文萃,张艳萍,房颖. 辛伐他汀治疗急性心肌梗死的作用机制研究[J]. 中国药房,2015,26(6):763-766.
[11] 李璐璐,李银花,刘梅颜. 中西医结合治疗急性心肌梗死的研究进展[J]. 中国循证心血管医学杂志,2016,8(1):115-117.
[12] 赵剑锋,刘静,郭颖,等. 红花注射液化学成分及其活性研究[J]. 中国中药杂志,2014,39(16):3102-3106.
[13] 陈培栋,房利勤. 红花注射液和注射用红花黄色素药理作用研究[J]. 世界中医药,2016,11(2):308-310.
[14] 宋世辉,张汝仙,刘明辉,等. 红花注射液对急性心肌梗死大鼠心功能的影响研究[J]. 现代中西医结合杂志,2017,26(10):1043-1045.
[15] 朱岩峰,罗海明,邓中龙,等. 红花注射液对急性冠状动脉综合征患者血小板糖蛋白Ⅱb/Ⅲa受体影响的随机对照研究[J]. 中西医结合学报,2012,10(3):318-323.
[16] Oliveira A L A, Scheffer J P, Markoski M, et al. Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs[J]. Acta Cir Bras, 2018, 33(4): 386-395.
[17] Aljakna A, Fracasso T, Sabatasso S. Molecular tissue changes in early myocardial ischemia: from pathophysiology to the identification of new diagnostic markers[J]. Int J Legal Med, 2018, 132(2): 425-438.
[18] Qiu C R, Fu Q, Sui J, et al. Serum endothelial cell-specific molecule 1 (endocan) levels in patients with acute myocardial infarction and its clinical significance[J]. Angiology, 2017, 68(4): 354-359.