纹美瞳线与干眼症的相关性研究
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摘要
目的探讨纹美瞳线与干眼症发病的关系。方法收集2013年9月至2016年12月于内蒙古医科大学附属医院眼科就诊的女性干眼症患者100例(200只眼)的临床资料。全部患者均纹刺过美瞳线,设为病例组。患者年龄为24~42岁,平均年龄为(28.5±8.3)岁;纹美瞳线的时间为2~8年,平均时间为(4.5±2.5)年。另选取未纹美瞳线及眼线的女性健康查体者100例(200只眼),设为对照组,年龄为23~44岁,平均年龄为(29.1±7.8)岁。比较两组研究对象的眼表疾病指数(OSDI)评分、角膜荧光染色评分、泪膜破裂时间(BUT)及泪液分泌试验(SIT)结果。病例组和对照组的OSDI评分、角膜荧光染色评分、SIT结果及BUT采用均数±标准差(x珋±s)表示,采用独立样本t检验进行组间均数比较。结果病例组患者的OSDI评分显示有轻度或中度的干眼症状,SIT结果倾向异常,BUT结果提示泪膜不稳定。病例组及对照组的OSDI评分分别为7.90±2.50及16.20±6.40,两组比较,差异有统计学意义(t=10.80,P<0.05)。病例组及对照组的角膜荧光染色评分分别为2.88±0.73及1.34±0.52,两组比较,差异有统计学意义(t=17.24,P<0.05)。病例组及对照组的SIT分别为(9.30±0.88)mm及(12.68±1.17)mm,两组比较,差异有统计学意义(t=23.06,P<0.05)。病例组及对照组的BUT分别为(4.17±0.89)s及(11.02±0.16)s,两组比较,差异有统计学意义(t=37.63,P<0.05)。结论纹美瞳线与干眼症的发生具有相关性。但纹美瞳线对于干眼症的病程及治疗的影响仍需进一步探讨。
Objective Researching and observing the relationship of tattooing contact lenses and dry eye.Methods The clinical data of 100 female dry eye patients( 200 eyes) were collected from September 2013 to December 2016 in the ophthalmology department of the Affiliated Hospital of Inner Mongolia Medical University.All the patients were set up as case group.The age of the patients were from 24 to 42 years,the age range were( 28.5±8.3) years,and the time of the tattoo pupil was from 2 to 8 years,and the age range were( 4.5±2.5) years.Another 100 female healthy subjects( 200 eyes) were selected as control group.The age were from 23 to 44 years and the range age were( 29.1 ± 7.8) years.Compared the scores of these two groups ocular surface disease index( OSDI),fluorescein vital staining,tear break-up time( BUT) and lacrimal secretion test( SIT).The OSDI score,corneal fluorescein staining score,SIT result and BUT in case group and control group were all expressed by mean ±standard deviation( x珋± s).An independent sample t-test was used to compare the average number of groups.Results The OSDI score of the patients in the case group showed mild or moderate dry eye symptoms,and the SIT results tended to be abnormal,and the BUT results suggested that the tear film was unstable.The OSDI scores in the case group and the control group were( 7.90± 2.50) and( 16.20 ± 6.40) respectively.The difference between the two groups was statistically significant( t = 10.8,P < 0.05).The corneal fluorescent staining scores in the case group and the control group were( 2.88± 0.73) and( 1.34 ± 0.52) respectively.The difference between the two groups was statistically significant( t = 17.24,P<0.05).The SIT in the case group and the control group were( 9.30 ± 0.88) mm and( 12.68 ± 1.17) mm respectively.The difference between the two groups was statistically significant( t = 23.06,P<0.05).Pattern of cosmetic contact lenses and a control group of BUT group respectively( 4.17 ± 0.89) s,( 11.02 ± 0.16) s,the two groups,the difference was statistically significant( t = 37.63,P<0.05).Conclusion There is a correlation between the striate eye pupil and the occurrence of dry eye.However,the influence of the tattoo pupil line on the course and treatment of dry eye should be further explored.
Objective Researching and observing the relationship of tattooing contact lenses and dry eye.Methods The clinical data of 100 female dry eye patients( 200 eyes) were collected from September 2013 to December 2016 in the ophthalmology department of the Affiliated Hospital of Inner Mongolia Medical University.All the patients were set up as case group.The age of the patients were from 24 to 42 years,the age range were( 28.5±8.3) years,and the time of the tattoo pupil was from 2 to 8 years,and the age range were( 4.5±2.5) years.Another 100 female healthy subjects( 200 eyes) were selected as control group.The age were from 23 to 44 years and the range age were( 29.1 ± 7.8) years.Compared the scores of these two groups ocular surface disease index( OSDI),fluorescein vital staining,tear break-up time( BUT) and lacrimal secretion test( SIT).The OSDI score,corneal fluorescein staining score,SIT result and BUT in case group and control group were all expressed by mean ±standard deviation( x珋± s).An independent sample t-test was used to compare the average number of groups.Results The OSDI score of the patients in the case group showed mild or moderate dry eye symptoms,and the SIT results tended to be abnormal,and the BUT results suggested that the tear film was unstable.The OSDI scores in the case group and the control group were( 7.90± 2.50) and( 16.20 ± 6.40) respectively.The difference between the two groups was statistically significant( t = 10.8,P < 0.05).The corneal fluorescent staining scores in the case group and the control group were( 2.88± 0.73) and( 1.34 ± 0.52) respectively.The difference between the two groups was statistically significant( t = 17.24,P<0.05).The SIT in the case group and the control group were( 9.30 ± 0.88) mm and( 12.68 ± 1.17) mm respectively.The difference between the two groups was statistically significant( t = 23.06,P<0.05).Pattern of cosmetic contact lenses and a control group of BUT group respectively( 4.17 ± 0.89) s,( 11.02 ± 0.16) s,the two groups,the difference was statistically significant( t = 37.63,P<0.05).Conclusion There is a correlation between the striate eye pupil and the occurrence of dry eye.However,the influence of the tattoo pupil line on the course and treatment of dry eye should be further explored.
引文
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[3]Ku9ukaydin M,Ozokutan BH,Turan C,et al.Malformation of the epididymis in undescended testis[J].Pediatric Surgery International,1998,14(3):189-191.
[4]中华医学会眼科学分会角膜病学组.干眼临床诊疗专家共识(2013年)[J].中华眼科杂志,2013,49(1):73-75.
[5]邢建男,赵海霞,隋瑶.干眼综合征的治疗进展[J].山东医药,2016,56(39):110-112.
[6]赵慧,刘祖国,杨文照,等.我国干眼问卷的研制及评估[J].中华眼科杂志,2015,51(9):647-654.
[7]Ban Y,Shimazaki-Den S,Tsubota K,et al.Morphological evaluation of meibomian glands using noncontact infrared meibography[J].Ocular Surface,2013,11(1):47-53.
[8]Finis D,Pischel N,Schrader S,et al.Evaluation of lipid layer thickness measurement of the tear film as a diagnostic tool for Meibomian gland dysfunction[J].Cornea,2013,32(12):1549-1553.
[9]Bitton E,Wittich W.Influence of eye position on the Schirmer tear test[J].Contact Lens&Anterior Eye,2014,37(4):257-261.
[10]Bron AJ,Smith JA,Calonge M.Methodologies to Diagnose and Monitor Dry Eye Disease:Report of the Diagnostic Methodology Subcommittee of the International Dry Eye Work Shop(2007)[J].Ocular Surface,2007,5(2):108-152.
[11]Nelson JD,Shimazaki J,Benitez-Del-Castillo JM,et al.The international workshop on meibomian gland dysfunction:report of the definition and classification subcommittee[J].Invest Ophthalmol Vis Sci,2011,52(4):1930-1937.
[12]Barabino S,Chen Y,Chauhan S,et al.Ocular surface immunity:Homeostatic mechanisms and their disruption in dry eye disease[J].Progress in Retinal&Eye Research,2012,31(3):271-285.
[13]Bron AJ,Tomlinson A,Foulks GN,et al.Rethinking Dry Eye Disease:A Perspective on Clinical Implications[J].Ocular Surface,2014,12(2):1-31.
[14]Hunter M,Bhola R,Yappert MC,et al.Pilot Study of the Influence of Eyeliner Cosmetics on the Molecular Structure of Human Meibum.[J].Ophthalmic Research,2015,53(3):131-135.
[15]Lemp MA.Advances in Understanding and Managing Dry Eye Disease[J].Am J Ophthalmol,2008,146(3):350-356.
[16]Yagci A,Gurdal C.The role and treatment of inflammation in dry eye disease[J].Int Ophthalmol,2014,34(6):1291-1301.
[17]龙潭,梁厚成,朱秀萍.纹眼线对于干眼症发病的影响[J].国际眼科杂志,2010,10(1):177-178.
[18]Shao Y,Yu Y,Yu J,et al.Experimental study on efficiency of Spanishneedles Herb eye drops in treating perimenopausal xerophthalmia in rabbits[J].China Journal of Chinese Materia Medica,2015,40(6):1151-1155.
[19]Li Y,Bookman AM.Limited Scleroderma(Crest Syndrome)is Associated with Worse Xerostomia and Xerophthalmia in Patients Being Evaluated for Primary Sjogren's Syndrome[J].Annals of the Rheumatic Diseases,2015,74(Suppl.2):583-584.
[20]Chiu M,Dillon A,Watson S.Vitamin A deficiency and xerophthalmia in children of a developed country[J].Journal ofPaediatrics&Child Health,2016,52(7):699-703.
[21]Kong X,Yan C,Ma W,et al.Sodium hyaluronate's effect on xerophthalmia:a meta-analysis of randomized controlled trials[J].Current Medical Research&Opinion,2016,32(3):477-484.
[22]Hui G,Zhao XD,Guo-Juan MA,et al.Acupuncture combined with pyonex for xerophthalmia[J].World Journal of AcupunctureMoxibustion,2016,26(2):37-42.
[23]Singh V,Jr WK.Vitamin A deficiency and xerophthalmia among school-aged children in Southeastern Asia[J].European Journal of Clinical Nutrition,2004,58(10):1342-1349.
[24]Naeini FF,Pourazizi M,Abtahi-Naeini B,et al.Looking beyond the cosmetic tattoo lesion near the eyebrow:Screening the lungs[J].Journal of Postgraduate Medicine,2017,63(2):132-134.
[25]Semba RD,De PS,Panagides D,et al.Risk factors for xerophthalmia among mothers and their children and for motherchild pairs with xerophthalmia in Cambodia[J].Archives of Ophthalmology,2004,122(4):517-523.
[26]Wang ZL,He HQ,Huang D,et al.Effect of integral syndrome differentiation acupuncture on the tear film stability in the patient of xerophthalmia[J].Chinese Acupuncture&Moxibustion,2005,25(7):460-463.
[27]Ma Y,Wang C,Liu M.Corneal epithelial cell apoptosis and related gene expression in castrated male rabbits with experimental xerophthalmia[J].Chinese Ophthalmic Research,2004,22(3):286-289.
[28]Baudouin C,Pisella PJ,Brignole F.Current treatments of xerophthalmia in Sj9gren's syndrome[J].Revue De Medecine Interne,2004,25(5):376-382.
[29]Khan AO.Xerophthalmia occurring after strabismus surgery[J].Journal of American Association for Pediatric Ophthalmology&Strabismus,2004,8(2):192-193.
[30]Gilbard JP,Farris RL,Nd SJ.Osmolarity of tear microvolumes in keratoconjunctivitis sicca[J].Arch Ophthalmol,1978,96(4):677-681.
[31]Dorado FM,Salasgarcía T,Lópezgómez A,et al.Granulomatous reaction in a patient with eyebrows tattoo[J].Medicina Clínica(English Edition),2016,146(1):e5.
[32]Liu ZY,Li CR.Teatment of dry eye caused by meibomianlang dysfunction[J].Int Eye Sci,2014,14(2):270-272.
[33]罗顺荣,邹留河,闫超,等.自体唇腺移植治疗重症干眼[J].中华眼科杂志,2013,49(1):22-26.
[34]陈志远,王静,吴晓霞,等.自体唇腺移植治疗重症角结膜干燥症[J].首都医科大学学报,2016,37(3):281-285.
[35]Eveleth DD.Cell-Based Therapies for Ocular Disease[J].Journal of Ocular Pharmacology&Therapeutics,2013,29(10):844-854.
[36]Glenn JD,Whartenby KA.Mesenchymal stem cells:emergingmechanismsof immunomodulation and therapy[J].World J Stem Cells,2014,6(5):526-539.
[37]Klinker MW,Wei CH.Mesenchymal stem cells in the treatment of inflammatory and autoimmune diseases in experimental animal models[J].World J Stem Cells,2015,7(3):556-567.
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