银杏叶提取物联合巴曲酶治疗突发性耳聋疗效的Meta分析
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摘要
目的系统评价银杏叶提取物(金纳多)联合巴曲酶治疗突发性耳聋(SHL)的疗效及ADR发生情况。方法计算机检索PubMed、Cochrane Library、万方数据库(WanFang Data)、维普数据库(VIP)、中国知网(CNKI)国内外数据库,收集银杏叶提取物联合巴曲酶治疗SHL的随机对照试验(RCTs)。根据Cochrane5.1手册要求,分别选择研究、提取数据并评价纳入研究的质量,采用RevMan5.1软件进行Meta分析。结果本研究共纳入8篇文献,包括899名受试者;与对照组相比,银杏叶提取物联合巴曲酶能提高治疗突发性耳聋的总有效率,其结果具有统计学差异[OR=4.18,95%CI(2.66,6.57),P<0.000 01];银杏叶提取物联合巴曲酶治疗突发性耳聋的总有效率优于对照组,其结果具有统计学差异[OR=2.30,95%CI(1.70,3.10),P<0.000 01];且其不良反应(ADR)发生情况较对照组减少。结论银杏叶提取物联合巴曲酶治疗突发性耳聋疗效,较单一使用效果更好,且ADR发生情况较为轻微,值得临床推广。但上述结论尚需要更多高质量大样本的临床对照试验加以验证。
Objective To systematically evaluate the efficacy of ginkgo biloba extract(ginaton) combined with batroxobin in the treatment of sudden hearing loss and the incidences of ADRs.Methods Pubmed, Cochrane Library, Wanfang Data, VIP and CNKI databases were searched with a computer. Randomized controlled trials(RCTs) of ginkgo biloba extract combined with batroxobin in the treatment of sudden hearing loss were collected. According to the requirements of Cochrane 5.1 manual, the researches were selected, the data were extracted and the quality of the research was evaluated. RevMan 5.1 software was used for meta-analysis.Results Eight literatures including 899 subjects were included in this study. Compared with the control group, ginkgo biloba extract combined with batroxobin can improve the total effective rate of sudden deafness, with statistical difference [OR=4.18, 95% CI(2.66, 6.57), P<0.00001]. The total effective rate of ginkgo biloba extract combined with batroxobin in the treatment of sudden deafness was significantly better than that of the control group, with statistical difference [OR=2.30, 95% CI(1.70, 3.10), P<0.000 01]; and the incidence of adverse reactions(ADR) was significantly less than that of the control group.Conclusion Ginkgo biloba extract combined with batroxobin in the treatment of sudden hearing loss is effective, better than its single use, and the incidence of ADR is slight, so it is worthy of clinical promotion. However, the above conclusions need to be verified by more high-quality large-sample clinical controlled trials.
Objective To systematically evaluate the efficacy of ginkgo biloba extract(ginaton) combined with batroxobin in the treatment of sudden hearing loss and the incidences of ADRs.Methods Pubmed, Cochrane Library, Wanfang Data, VIP and CNKI databases were searched with a computer. Randomized controlled trials(RCTs) of ginkgo biloba extract combined with batroxobin in the treatment of sudden hearing loss were collected. According to the requirements of Cochrane 5.1 manual, the researches were selected, the data were extracted and the quality of the research was evaluated. RevMan 5.1 software was used for meta-analysis.Results Eight literatures including 899 subjects were included in this study. Compared with the control group, ginkgo biloba extract combined with batroxobin can improve the total effective rate of sudden deafness, with statistical difference [OR=4.18, 95% CI(2.66, 6.57), P<0.00001]. The total effective rate of ginkgo biloba extract combined with batroxobin in the treatment of sudden deafness was significantly better than that of the control group, with statistical difference [OR=2.30, 95% CI(1.70, 3.10), P<0.000 01]; and the incidence of adverse reactions(ADR) was significantly less than that of the control group.Conclusion Ginkgo biloba extract combined with batroxobin in the treatment of sudden hearing loss is effective, better than its single use, and the incidence of ADR is slight, so it is worthy of clinical promotion. However, the above conclusions need to be verified by more high-quality large-sample clinical controlled trials.
引文
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[10] 孟晓敏,李华瑞,刘峰,等.银杏叶提取物联合巴曲酶对突发性耳聋患者血液流变学及凝血功能的影响[J].现代中西医结合杂志.2018,27(27):3041-3044.
[11] 张学红,梁小微,王鸿梅,等.巴曲酶联合银杏叶注射液治疗突发性耳聋的疗效及对患者凝血功能的影响[J].河北医学,2018,24(6):979-983.
[12] 邵玉玺,姜春丽.巴曲酶和银杏叶提取物注射液治疗高龄患者突发性耳聋的疗效观察[J].北方药学,2018,15(10):69-70.
[13] 王雁,杨义芳.银杏叶的药理作用及其机制的研究进展[J].中国现代应用药学,2001(1):1-4.
[2] 曾国勇,李广生.巴曲酶治疗突发性耳聋的Meta分析[J].赣南医学院学报,2015,35(1):70-75.
[3] 杜莉,李涛.金纳多注射液治疗突发性耳聋的Meta分析[J].中国药房,2007,18(24):1898-1900.
[4] 梁好勇,张孟丽,王慎祥,等.巴曲酶注射液联合银杏叶提取物注射液对老年突发性耳聋患者纯音听阈变化及预后的影响[J].实用中西医结合临床,2017,17(4):93-94.
[5] 王亚莉.银杏叶提取物联合巴曲酶治疗高海拔地区突发性耳聋临床疗效观察[J].青海医药杂志,2017,47(3):23-24.
[6] 贾晓东,史保轩.巴曲酶联合金纳多治疗突发性耳聋的疗效及对血流动力学的影响[J].中国合理用药探索,2017,14(10):42-44.
[7] 邝萍兰.巴曲酶注射液联合金纳多治疗突发性耳聋临床疗效分析[J].海峡药学,2017,29(5):131-132.
[8] 田勇泉.耳鼻咽喉头颈外科学[M].8版.北京:人民卫生出版社,2013:286-297.
[9] 刘春玲,张少燕,梁久平,等.金纳多联合巴曲酶治疗突发性耳聋疗效及对血液流变学与内皮功能影响[J].临床军医杂志,2018,46(4):476-480.
[10] 孟晓敏,李华瑞,刘峰,等.银杏叶提取物联合巴曲酶对突发性耳聋患者血液流变学及凝血功能的影响[J].现代中西医结合杂志.2018,27(27):3041-3044.
[11] 张学红,梁小微,王鸿梅,等.巴曲酶联合银杏叶注射液治疗突发性耳聋的疗效及对患者凝血功能的影响[J].河北医学,2018,24(6):979-983.
[12] 邵玉玺,姜春丽.巴曲酶和银杏叶提取物注射液治疗高龄患者突发性耳聋的疗效观察[J].北方药学,2018,15(10):69-70.
[13] 王雁,杨义芳.银杏叶的药理作用及其机制的研究进展[J].中国现代应用药学,2001(1):1-4.