茵栀黄颗粒治疗肿瘤化疗后肝损伤的临床观察
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摘要
目的观察茵栀黄颗粒治疗肿瘤化疗后肝损伤的疗效及不良反应。方法化疗后出现Ⅱ度以上肝损伤的肿瘤患者65例,随机分为茵栀黄颗粒组34例与还原型谷胱甘肽组31例,观察两组治疗前后转氨酶及胆红素,并比较疗效。结果茵栀黄颗粒组和还原型谷胱甘肽组在降低转氨酶有效率分别为96.6%和96.4%,两组无显著性差异;在降低胆红素方面茵栀黄颗粒组有效率为93.7%,明显优于还原型谷胱甘肽组(60%),P<0.05。对照组显效率为45.2%,总效率为83.9%;治疗组显效率为52.9%,总效率为94.1%,远高于对照组,差异统计学意义(P<0.05);对照组无效率为16.1%,远高于治疗组的5.9%,二者差异统计学意义(P<0.05)。两组均未见明显不良反应。结论茵栀黄颗粒用于治疗肿瘤化疗后肝损伤安全有效,尤其适用于胆红素较高者。
Objective To observe the efficacy of Yinzhihuang granula for tumor patients with impairment of liver function after chemotherapy.Methods 65 cancer patients with liver dysfunction after chemotherapy were radomized into two groups.Therapeutic group was treated by Yinzhihuang granula and control groups was treated by reduced glutathione.Results The recovery rates of therapeutic group and control group was 96.6% and 96.4% in decrease of ALT and AST,which was no significance difference in two groups.But the recovery rates of therapeutic was higher than control group significantly in decrease of high-jaundice,P<0.05.The total efficiency was 83.9%.The total efficiency of the treatment group was 94.1%.The difference was statistically significant(P<0.05).The inefficiencies of the control group were 16.1%,much higher than that of the treatment group(5.9%),and the difference was statistically significant(P<0.05).There was no obvious side effects observed during therapy.Conclusion Yinzhihuan granula obviously curative effective and safety in impairment of liver function after chemotherapy.
Objective To observe the efficacy of Yinzhihuang granula for tumor patients with impairment of liver function after chemotherapy.Methods 65 cancer patients with liver dysfunction after chemotherapy were radomized into two groups.Therapeutic group was treated by Yinzhihuang granula and control groups was treated by reduced glutathione.Results The recovery rates of therapeutic group and control group was 96.6% and 96.4% in decrease of ALT and AST,which was no significance difference in two groups.But the recovery rates of therapeutic was higher than control group significantly in decrease of high-jaundice,P<0.05.The total efficiency was 83.9%.The total efficiency of the treatment group was 94.1%.The difference was statistically significant(P<0.05).The inefficiencies of the control group were 16.1%,much higher than that of the treatment group(5.9%),and the difference was statistically significant(P<0.05).There was no obvious side effects observed during therapy.Conclusion Yinzhihuan granula obviously curative effective and safety in impairment of liver function after chemotherapy.
引文
1孙元珏,祁伟祥,姚阳.还原型谷胱甘肽与肿瘤化疗相关性肝损伤的防治[J].中国肿瘤,2015,24(1):57-63.
2丁建华,汤巧云,孙萍,等.晚期非小细胞肺癌患者化疗后肝损伤164例临床分析[J].肿瘤研究与临床,2015,27(1):39-43.
3宇文利霞,梁平,袁耀辉,等.肿瘤化疗致药物性肝损伤患者的用药分析1例[J].中国新药与临床杂志,2016,35(9):680-682.
4曾乌查,林学德,张志锋,等.双环醇片防治肿瘤化疗药物性肝损害的研究[J].中国当代医药,2011,18(17):5-6.
5张剑.还原型谷胱甘肽对恶性肿瘤化疗后肝损伤的疗效观察[J].浙江中医药大学学报,2014,38(5):601-602.
6丁建华,汤巧云,孙萍,等.晚期非小细胞肺癌患者化疗后肝损伤164例临床分析[J].肿瘤研究与临床,2015,27(1):39-43.
7秦叔逵,杨柳青,王科明,等.异甘草酸镁注射液预防抗肿瘤化疗相关性急性肝损伤的随机对照、全国多中心临床研究[J].临床肿瘤学杂志,2017,22(2):97-106.
8李瑞超,郑丽君,房明浩.思美泰治疗化疗后肝功能损害的临床观察[J].临床消化病杂志,2011,23(4):198-199,211.
9崔宪珍,刘都户.还原型谷胱甘肽防治化疗药物肝损害126例临床观察[J].陕西医学杂志,2008,37(7):931-932.
10方林,魏宁,徐浩,等.还原型谷胱甘肽在原发性肝癌介入治疗后保肝作用中的临床应用[J].介入放射学杂志,2017,26(2):169-172.
11张剑.还原型谷胱甘肽对恶性肿瘤化疗后肝损伤的疗效观察[J].浙江中医药大学学报,2014,38(5):601-602.
12郭青龙,郭殿武,陈真.茵栀黄注射液保肝作用的实验研究[J].中国药科大学学报,2001,32(6):440-443.
13李瑞芬,范玉明,王希海.茵栀黄注射液对大鼠实验性肝损伤的治疗作用[J].中药药理与临床,2001,17(2):23-24.
2丁建华,汤巧云,孙萍,等.晚期非小细胞肺癌患者化疗后肝损伤164例临床分析[J].肿瘤研究与临床,2015,27(1):39-43.
3宇文利霞,梁平,袁耀辉,等.肿瘤化疗致药物性肝损伤患者的用药分析1例[J].中国新药与临床杂志,2016,35(9):680-682.
4曾乌查,林学德,张志锋,等.双环醇片防治肿瘤化疗药物性肝损害的研究[J].中国当代医药,2011,18(17):5-6.
5张剑.还原型谷胱甘肽对恶性肿瘤化疗后肝损伤的疗效观察[J].浙江中医药大学学报,2014,38(5):601-602.
6丁建华,汤巧云,孙萍,等.晚期非小细胞肺癌患者化疗后肝损伤164例临床分析[J].肿瘤研究与临床,2015,27(1):39-43.
7秦叔逵,杨柳青,王科明,等.异甘草酸镁注射液预防抗肿瘤化疗相关性急性肝损伤的随机对照、全国多中心临床研究[J].临床肿瘤学杂志,2017,22(2):97-106.
8李瑞超,郑丽君,房明浩.思美泰治疗化疗后肝功能损害的临床观察[J].临床消化病杂志,2011,23(4):198-199,211.
9崔宪珍,刘都户.还原型谷胱甘肽防治化疗药物肝损害126例临床观察[J].陕西医学杂志,2008,37(7):931-932.
10方林,魏宁,徐浩,等.还原型谷胱甘肽在原发性肝癌介入治疗后保肝作用中的临床应用[J].介入放射学杂志,2017,26(2):169-172.
11张剑.还原型谷胱甘肽对恶性肿瘤化疗后肝损伤的疗效观察[J].浙江中医药大学学报,2014,38(5):601-602.
12郭青龙,郭殿武,陈真.茵栀黄注射液保肝作用的实验研究[J].中国药科大学学报,2001,32(6):440-443.
13李瑞芬,范玉明,王希海.茵栀黄注射液对大鼠实验性肝损伤的治疗作用[J].中药药理与临床,2001,17(2):23-24.