胃丛状纤维黏液瘤2例报道并文献复习
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摘要
胃丛状纤维黏液瘤(plexiform fibromyxoma of stomach,PF)是一种罕见的胃间叶源性肿瘤,因呈特征性的丛状生长,细胞间富含黏液状基质和薄壁的小血管而得名。本文报道了武汉大学人民医院2例胃丛状纤维黏液瘤患者,并复习相关文献总结了其临床表现、组织学和病理学特征、免疫表型及鉴别诊断,希望对临床上的胃丛状纤维黏液瘤诊断有所帮助。
Plexiform fibromyxoma of stomach is a rare mesenchymal tumor of gastric,with the characteristics of the plexiform growth,intercellular myxoid matrix and small blood vessels. In this article,two cases of plexiform fibromyxoma of stumach were reported and related literatures were reviewed,the clinical manifestations,features of histology and pathology,immunophenotype and differential diagnosis of it were summarized,to help clinically diagnosis in the plexiform fibromyxoma of stumach.
Plexiform fibromyxoma of stomach is a rare mesenchymal tumor of gastric,with the characteristics of the plexiform growth,intercellular myxoid matrix and small blood vessels. In this article,two cases of plexiform fibromyxoma of stumach were reported and related literatures were reviewed,the clinical manifestations,features of histology and pathology,immunophenotype and differential diagnosis of it were summarized,to help clinically diagnosis in the plexiform fibromyxoma of stumach.
引文
[1]TAKAHASHI Y,SHIMIZU S,ISHIDA T,et al.Plexiform angiomyxoid myofibroblastic tumor of the stomach[J].Am J Surg Pathol,2007,31(5):724-728.DOI:10.1097/01.pas.0000213448.54643.2f.
[2]LEE P W,YAU D T,LAU P P,et al.Plexiform fibromyxoma(plexiform angiomyxoid myofibroblastic tumor)of stomach:an unusual presentation as a fistulating abscess[J].Int J Surg Pathol,2014,22(3):286-290.DOI:10.1177/1066896913492198.
[3]BANERJEE N,GUPTA S,DASH S,et al.Plexiform angiomyxoid myofibroblastic tumour of the duodenum:a rare entity[J].BMJ Case Rep,2015.pii:bcr2015210004.DOI:10.1136/bcr-2015-210004.
[4]MORIS D,SPANOU E,SOUGIOULTZIS S,et al.Duodenal plexiform fibromyxoma as a cause of obscure upper gastrointestinal bleeding:A case report[J].Medicine(Baltimore),2017,96(1):e5883.DOI:10.1097/MD.0000000000005883.
[5]DUCKWORTH L V,GONZALEZ R S,MARTELLI M,et al.Plexiform fibromyxoma:report of two pediatric cases and review of the literature[J].Pediatr Dev Pathol,2014,17(1):21-27.DOI:10.2350/13-09-1373-OA.1.
[6]SPANS L,FLETCHER C D,ANTONESCU C R,et al.Recurrent MALAT1-GLI1 oncogenic fusion and GLI1 up-regulation define a subset of plexiform fibromyxoma[J].J Pathol,2016,239(3):335-343.DOI:10.1002/path.4730.
[7]FASSAN M,SALMASO R,SARAGGI D,et al.Plexiform fibromyxoma of the gallbladder[J].Pathologica,2015,107(3-4):181-184.
[8]DAUM O,JIRASEK T,GROSSMANN P,et al.Plexiform fibroma of the colon[J].Appl Immunohistochem Mol Morphol,2010,18(5):483-484.DOI:10.1097/PAI.0b013e3181d84b69.
[9]LI X,LI S,XIONG S,et al.A rare case of plexiform angiomyxoid myofibroblastic tumor in the stomach which was diagnosed at the earliest stage in the literature[J].Gastroenterol Rep(Oxf),2016.pii:gow035.DOI:10.1093/gastro/gow035.
[10]MIETTINEN M,MAKHLOUF H R,SOBIN L H,et al.Plexiform fibromyxoma:a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST[J].Am J Surg Pathol,2009,33(11):1624-1632.DOI:10.1097/PAS.0b013e3181ae666a.
[11]TAKAHASHI Y,SUZUKI M,FUKUSATO T,et al.Plexiform angiomyxoid myofibroblastic tumor of the stomach[J].World J Gastroenterol,2010,16(23):2835-2840.
[12]GONZALEZ-CORDERO P L,VARA-BRENES D,PECERO-HORMIGO M D C,et al.Plexiform fibromyxoma,a rare mesenchymal gastric tumor[J].Gastroenterol Hepatol,2018,41(3):166-167.DOI:10.1016/j.gastrohep.2017.03.003.
[13]KITAMURA Y.Gastrointestinal stromal tumors:past,present,and future[J].J Gastroenterol,2008,43(7):499-508.DOI:10.1007/s00535-008-2200-y.
[14]MIETTINEN M,SOBIN L H,LASOTA J.Gastrointestinal stromal tumors of the stomach:a clinicopathologic,immunohistochemical,and molecular genetic study of 1765 cases with long-term follow-up[J].Am J Surg Pathol,2005,29(1):52-68.
[2]LEE P W,YAU D T,LAU P P,et al.Plexiform fibromyxoma(plexiform angiomyxoid myofibroblastic tumor)of stomach:an unusual presentation as a fistulating abscess[J].Int J Surg Pathol,2014,22(3):286-290.DOI:10.1177/1066896913492198.
[3]BANERJEE N,GUPTA S,DASH S,et al.Plexiform angiomyxoid myofibroblastic tumour of the duodenum:a rare entity[J].BMJ Case Rep,2015.pii:bcr2015210004.DOI:10.1136/bcr-2015-210004.
[4]MORIS D,SPANOU E,SOUGIOULTZIS S,et al.Duodenal plexiform fibromyxoma as a cause of obscure upper gastrointestinal bleeding:A case report[J].Medicine(Baltimore),2017,96(1):e5883.DOI:10.1097/MD.0000000000005883.
[5]DUCKWORTH L V,GONZALEZ R S,MARTELLI M,et al.Plexiform fibromyxoma:report of two pediatric cases and review of the literature[J].Pediatr Dev Pathol,2014,17(1):21-27.DOI:10.2350/13-09-1373-OA.1.
[6]SPANS L,FLETCHER C D,ANTONESCU C R,et al.Recurrent MALAT1-GLI1 oncogenic fusion and GLI1 up-regulation define a subset of plexiform fibromyxoma[J].J Pathol,2016,239(3):335-343.DOI:10.1002/path.4730.
[7]FASSAN M,SALMASO R,SARAGGI D,et al.Plexiform fibromyxoma of the gallbladder[J].Pathologica,2015,107(3-4):181-184.
[8]DAUM O,JIRASEK T,GROSSMANN P,et al.Plexiform fibroma of the colon[J].Appl Immunohistochem Mol Morphol,2010,18(5):483-484.DOI:10.1097/PAI.0b013e3181d84b69.
[9]LI X,LI S,XIONG S,et al.A rare case of plexiform angiomyxoid myofibroblastic tumor in the stomach which was diagnosed at the earliest stage in the literature[J].Gastroenterol Rep(Oxf),2016.pii:gow035.DOI:10.1093/gastro/gow035.
[10]MIETTINEN M,MAKHLOUF H R,SOBIN L H,et al.Plexiform fibromyxoma:a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST[J].Am J Surg Pathol,2009,33(11):1624-1632.DOI:10.1097/PAS.0b013e3181ae666a.
[11]TAKAHASHI Y,SUZUKI M,FUKUSATO T,et al.Plexiform angiomyxoid myofibroblastic tumor of the stomach[J].World J Gastroenterol,2010,16(23):2835-2840.
[12]GONZALEZ-CORDERO P L,VARA-BRENES D,PECERO-HORMIGO M D C,et al.Plexiform fibromyxoma,a rare mesenchymal gastric tumor[J].Gastroenterol Hepatol,2018,41(3):166-167.DOI:10.1016/j.gastrohep.2017.03.003.
[13]KITAMURA Y.Gastrointestinal stromal tumors:past,present,and future[J].J Gastroenterol,2008,43(7):499-508.DOI:10.1007/s00535-008-2200-y.
[14]MIETTINEN M,SOBIN L H,LASOTA J.Gastrointestinal stromal tumors of the stomach:a clinicopathologic,immunohistochemical,and molecular genetic study of 1765 cases with long-term follow-up[J].Am J Surg Pathol,2005,29(1):52-68.