长链非编码RNA-LET在肿瘤中的研究进展
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摘要
肿瘤低表达ln RNA(lncRNA-LET)定位于15号染色体长臂2区4带15q24.1,具有抑制肿瘤的发生、发展、转移和促进凋亡的作用,已经被证实其存在于多种肿瘤组织中,且其表达下调。目前研究认为lncRNA-LET通过竞争性结合微小RNA(miRNA)作为竞争性内源RNA(ceRNA)而发挥作用,并充当该组miRNA的"分子海绵"。lncRNA-LET是目前研究的热点,其有望成为一种新的肿瘤诊断和预后的标志物以及潜在的治疗靶点。本文综述了近年来lncRNA-LET在肿瘤中的作用的先关研究,以期为ncRNA-LET与肿瘤的进一步研究提供参考。
Tumor low expression of lnRNA(lncRNA-LET) is located in 15 q24.1 of 4 bands of 2 region of long arm of chromosome 15, which can inhibit the occurrence, development, metastasis and apoptosis of tumors. It has been proved that lncRNA-LET exists in various tumors and its expression is down-regulated. At present, it is believed that lncR-NA-LET plays a role as a competing endogenous RNA(ceRNA) by competing with microRNAs(mi RNAs)and acts as a "molecular sponge" of this group of miRNAs. LncRNA-LET is a hotspot of current research, which is expected to become a new marker for diagnosis and prognosis of tumors and a potential therapeutic target. This paper reviews the recent phase studies on the role of lncRNA-LET in tumors, with a view to providing reference for further research on ncRNA-LET and tumors.
Tumor low expression of lnRNA(lncRNA-LET) is located in 15 q24.1 of 4 bands of 2 region of long arm of chromosome 15, which can inhibit the occurrence, development, metastasis and apoptosis of tumors. It has been proved that lncRNA-LET exists in various tumors and its expression is down-regulated. At present, it is believed that lncR-NA-LET plays a role as a competing endogenous RNA(ceRNA) by competing with microRNAs(mi RNAs)and acts as a "molecular sponge" of this group of miRNAs. LncRNA-LET is a hotspot of current research, which is expected to become a new marker for diagnosis and prognosis of tumors and a potential therapeutic target. This paper reviews the recent phase studies on the role of lncRNA-LET in tumors, with a view to providing reference for further research on ncRNA-LET and tumors.
引文
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[28] Kumar MS,Armenterosmonterroso E,East P,et al. Hmga2 functions as a competing endogenous RNA to promote lung cancer progression[J]. Nature,2014,505(7482):212-217.
[29] Wang WT,Ye H,Wei PP,et al. LncRNAs H19 and HULC,actived by oxidative stress,promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner[J].J Hematol Oncol,2016,9(1):117.
[30] Ma M,Kong X,Weng M,et al. Long non-coding RNALET is a positive prognostic factor and exhibits tumorsuppresive activity in gallbladder cancer[J]. Mol Carcinog,2015,54(11):1397-1406.
[31] Zhou B,Jing XY,Wu JQ,et al. Down-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer[J]. Int J Clin Exp Pathol,2014,7(12):8893-8898.
[32] Franklin JL,Rankin CR,Levy S,et al. Malignant transformation of clonic epithelial cells by a colon-derived long noncoding RNA[J]. Biochem Biophys Res Commun,2013,440(1):99-104.
[33] Jiang S,Wang HL,Yang J. Low expression of long noncoding RNA LET inhibits carcinogenesis of cervical cancer[J]. Int J Clin Exp Pathol,2015,8(1):806-811.
[34] Gao Y,Meng H,Liu S,et al. LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b[J].Hum Mol Genet,2015,24(3):841.
[35] Zhang T,Men Y,Lu L,et al. Metformin alters DNA methylation genome-wide via the H19/SAHH axis[J]. Oncogene,2017,36(17):2345-2354.
[2] Dror S,Sander L,Schwartz H,et al. Melanoma miRNA trafficking controls tumor primary niche formation[J]. Nat Cell Bio,2016,18(9):1006-1017.
[3] Chen Z,Lin J,Wu S,et al. Up-regulated miR-548k promotes esophageal squamous cell carcinoma progression via targeting long noncoding RNA-LET[J]. Exp Cell Res,2017,362(1):90-101.
[4] Ramachandran R,Fausett BV,Goldman D. Asl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28-dependent,let-7 microRNA signaling pathway[J]. Nat Cell Bio,2010,12(11):1101-1107.
[5] Wang Y,Xu Z,Jiang J,et al. Endogenous miRNA sponge lincRNA-RoR regulates Oct4,Nanog,and Sox2 in human embryonic stem cell self-renewal[J]. Dev Cell,2013,25(1):69-80.
[6] Sumazin P,Yang X,Chiu HS,et al. An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma[J]. Cell,2011,147(2):370-381.
[7] Liang D,Yang SB,Xu FF,et al. Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge[J]. J Exp Clin Cancer Res,2015,34(1):1-10.
[8]郑婷婷,邱君君.缺氧肿瘤微环境对长链非编码RNA作用的研究进展[J].现代妇产科进展,2018,27(2):145-148.
[9] Yang F,Huo XS,Yuan SX,et al. Repression of the Long Non-Coding RNA-LET by Histone Deacetylase3 Contributes to Hypoxia-Mediated Metastasis[J]. Mol Cell,2013,49(6):1083-1096.
[10] Maldotti M,Incarnato D,Neri F,et al. The long intergenic non-coding RNA CCR492 functions as a let-7competitive endogenous RNA to regulate c-Myc expression[J]. Biochim Biophys Acta,2016,1859(10):1322.
[11] Sun Q,Liu H,Li L,et al. Long noncoding RNA-LET,which is repressed by EZH2,inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell[J].Med Oncol,2015,32(9):226.
[12] Lei C,Sun L,Lei D,et al. The role of lon noncoding RNA-LET in cell proliferation and invasion of nasopharyngeal carcinoma and its mechanism[J]. Onco Targets Ther,2017,10:2769-2778.
[13] Zhang SQ,Cai WJ,Huang JH,et al. Icariin,a natural flavonol glycoside,extends healthspan in mice[J]. Exp Gerontol,2015,69:226-235.
[14] Wang Y,Cheng N,Luo J. Down regulation of lncRNA ANRIL represses tumorigenicity and enhances cisplatin-induced cytotoxicity via regulating microRNA let-7a in nasopharygeal carcinoma[J]. J Biochem Mol Toxicol,2017,31(7):e21 904
[15] Torre LA,Bray F,Siegel RL,et al. Global cancer statistics,2012[J]. CA Cancer J Clin,2015,65(2):87-108.
[16] Song Y,Li L,Ou Y,et al. Identification of genomic alterations in oesophageal squamous cell cancer[J]. Nature,2014,509(7498):91-95.
[17] Liu B,Pan CF,He ZC,et al. Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma[J]. BioMed Res Int,2016(1):4 693 471.
[18] Chou YS,Yang MH. Epithelial-mesenchymal transitionrelated factors in solid tumor and hematological malignancy[J]. J Chin Med Assoc,2015,78(8):438-445.
[19] Vadde R,Radhakrishman S,Reddivari L,et al. Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing cMyc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio[J].Biomed Res Int,2015(28):649 263.
[20] Lu L,Qi H,Luo F,et al. Feedback circuitry via let-7c between lncRNA CCAT1 and c-Myc is involved in cigarette smoke extract-induced malignant transformation of HBE cells[J]. Oncotarget,2017,8(12):19 285.
[21] Sun J,Pan LM,Chen LB,et al. LncRNA XIST promotes human lung adenocarcinoma cells to cisplatin resistance via let-7i/BAG-1 axis[J]. Cell Cycle,2017,16(21):1-8.
[22] Greenhough J,Papadakis ES,Cutress RI,et al. Regulation of osteoblast development by Bcl-2-associated at hanogene-1(BAG-1)[J]. Sci Rep,2016,6:33 504.
[23] Peng F,Li TT,Wang KL,et al. H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance[J]. Cell Death Dis,2017,8(1):e2569.
[24] Ma C,Nong K,Zhu H,et al. H19 promotes pancreatic cancer metastasis by derepressing let-7’s suppression on its target HMGA2-mediated EMT[J]. Tumour Biol,2014,35(9):9163-9169.
[25] Zhou W,Ye XL,Xu J,et al. The lnRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b[J]. Sci Signal,2017,10(483):eaak9557.
[26] Shi W,Zhang Z,Yang B,et al. Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma[J]. Medicine,2017,96(32):e7764.
[27] Kallen AN,Zhou XB,Xu J,et al. The imprinted H19 lncRNA antagonizes let-7 miroRNAs[J]. Mol Cell,2013,52(1):101-112.
[28] Kumar MS,Armenterosmonterroso E,East P,et al. Hmga2 functions as a competing endogenous RNA to promote lung cancer progression[J]. Nature,2014,505(7482):212-217.
[29] Wang WT,Ye H,Wei PP,et al. LncRNAs H19 and HULC,actived by oxidative stress,promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner[J].J Hematol Oncol,2016,9(1):117.
[30] Ma M,Kong X,Weng M,et al. Long non-coding RNALET is a positive prognostic factor and exhibits tumorsuppresive activity in gallbladder cancer[J]. Mol Carcinog,2015,54(11):1397-1406.
[31] Zhou B,Jing XY,Wu JQ,et al. Down-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer[J]. Int J Clin Exp Pathol,2014,7(12):8893-8898.
[32] Franklin JL,Rankin CR,Levy S,et al. Malignant transformation of clonic epithelial cells by a colon-derived long noncoding RNA[J]. Biochem Biophys Res Commun,2013,440(1):99-104.
[33] Jiang S,Wang HL,Yang J. Low expression of long noncoding RNA LET inhibits carcinogenesis of cervical cancer[J]. Int J Clin Exp Pathol,2015,8(1):806-811.
[34] Gao Y,Meng H,Liu S,et al. LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b[J].Hum Mol Genet,2015,24(3):841.
[35] Zhang T,Men Y,Lu L,et al. Metformin alters DNA methylation genome-wide via the H19/SAHH axis[J]. Oncogene,2017,36(17):2345-2354.