医用射线防护喷剂对乳腺癌改良根治术后放疗急性放射性皮炎的作用研究
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摘要
目的:观察乳腺癌改良根治术后放疗医用射线防护喷剂对胸壁及锁骨上下区皮肤急性放射反应的疗效。方法:乳腺癌改良根治术后患者75例,随机分为两组(其中41例照射区使用医用射线防护喷剂,为观察组;34例未使用射线防护喷剂,为对照组),放疗剂量分割方案为胸壁±锁骨上下区50Gy/25次。结果:两组患者照射结束时均发生皮肤反应,观察组急性皮肤反应严重程度明显低于对照组(P<0.05),观察组出现急性皮肤反应的发生率在2周内较对照组明显降低(P<0.05)。结论:医用射线防护喷剂能有效减轻和推迟乳腺癌改良根治术后放疗的胸壁及锁骨上下区严重急性放射性皮肤反应的发生、减轻患者痛苦,提高患者生活质量,并保证放射治疗的顺利进行。
Objective:To observe effective of protective spray in preventing acute cutireaction in chest wall and infra-supraclavicular region after receiving radiotherapy with postmastectomy.Methods:75 patients with breast cancer were collected,these patients were randomly divided into the observe group(41 participants,with protective spray after receiving radiotherapy)and the control group(34 participants,without use protective spray).Radiation dose and fractionation mode was chest wall irradiation(±infrasupraclavicular region)required a dose of 50 Gy/25 fractions.Results:After irradiation,patients in two group would have cutireaction.The level of severity in observe group was much lower than in control group(P<0.05).The rates of acute cutireaction in observe group was much lower than in control group in two weeks(P<0.05).Conclusions:Protective spray can ease and put off the cutireaction occurring for chest wall and infrasupraclavicular region with postmastectomy,and lighten the patient's suffering and increase the quality of patient's life and ensure the therapy complete in time.
Objective:To observe effective of protective spray in preventing acute cutireaction in chest wall and infra-supraclavicular region after receiving radiotherapy with postmastectomy.Methods:75 patients with breast cancer were collected,these patients were randomly divided into the observe group(41 participants,with protective spray after receiving radiotherapy)and the control group(34 participants,without use protective spray).Radiation dose and fractionation mode was chest wall irradiation(±infrasupraclavicular region)required a dose of 50 Gy/25 fractions.Results:After irradiation,patients in two group would have cutireaction.The level of severity in observe group was much lower than in control group(P<0.05).The rates of acute cutireaction in observe group was much lower than in control group in two weeks(P<0.05).Conclusions:Protective spray can ease and put off the cutireaction occurring for chest wall and infrasupraclavicular region with postmastectomy,and lighten the patient's suffering and increase the quality of patient's life and ensure the therapy complete in time.
引文
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[12]余晓侠,王贤卿,黄凤仙,等.医用射线防护喷剂联合蛋黄油在乳腺癌放疗中的应用[J].陕西医学杂志,2016,45(8):1101.
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[16]李祎萍.两种防护喷剂用于预防放射性皮炎的效果比较[J].实用临床医药杂志,2016,20(2):146-147.
[2]李香,刘景华.医用射线防护喷剂预防乳腺癌放疗患者放射性皮炎的疗效观察[J].中国保健营养:下旬刊,2014,22(5):2874-2875.
[3]王健.医用射线防护喷剂对乳腺癌放疗患者的放射性皮炎的疗效[J].中外健康文摘,2012(31):123-123.
[4]陈祥娥,凌沛学,张天民.超氧化物歧化酶的应用[J].食品与药品,2013,15(04):283-285.
[5]夏安林,陈姝.医用射线防护喷剂对预防皮肤放射性损伤效果观察[J].中国美容医学,2012,21(12):299.
[6]黄绍叶,孙宏霏,徐德宏.医用射线防护喷剂对放疗中黏膜反应的疗效观察及护理[J].护士进修杂志,2012,27(18):1701-1703.
[7]李祎萍.医用射线防护喷剂应用在乳腺癌患者急性放射性皮肤损伤中的效果[J].实用临床护理学电子杂志,2016,1(12):167,169.
[8]李彩萍,李淑珍,张钦华,等.46例鼻咽癌放射性皮炎应用奥克喷的护理效果[J].中国医药指南,2013,11(34):317-318.
[9]Petkau A.Role of SOD in modifi cation of radiation injury[J].Br J Cancer,l987,55:87-95.
[10]Campana F,Zervoudis S,Perdereau B,et al.Topical superoxide dismutase reduces post-irradiation breast cancer fibrosis[J].J Cell Mol Med,2004,8:109-116.
[11]赵全娣,戴小明,薛敏芬,等.抗辐喷预防乳腺癌术后急性放射性皮炎的效果[J].中华现代护理杂志,2012,18(29):3494-3495.
[12]余晓侠,王贤卿,黄凤仙,等.医用射线防护喷剂联合蛋黄油在乳腺癌放疗中的应用[J].陕西医学杂志,2016,45(8):1101.
[13]罗金秀,付喜秀,吴冬梅.医用射线防护喷剂治疗Ⅱ度放射性皮炎的效果观察[J].护理实践与研究,2013,10(9):118.
[14]严凌花,刘心慧,石秀芳,等.奥克喷防治鼻咽癌急性皮肤黏膜放射性损伤效果观察[J].护理研究,2016,30(2):468-470.
[15]赵娟.奥克喷预防乳腺癌术后放射性皮肤损伤临床研究[J].内蒙古医学杂志,2014,46(10):1185-1187.
[16]李祎萍.两种防护喷剂用于预防放射性皮炎的效果比较[J].实用临床医药杂志,2016,20(2):146-147.