氯吡格雷联合大剂量阿托伐他汀对脑梗死患者神经功能及生活能力的影响
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摘要
目的探讨氯吡格雷联合大剂量阿托伐他汀药物治疗脑梗死的效果。方法选择2015年12月—2017年12月间收治的脑梗死患者106例,按照用药方法的不同划分为研究组与常规组各53例,研究组使用氯吡格雷联合大剂量阿托伐他汀药物治疗,常规组实施常规剂量阿托伐他汀治疗,评估患者活动表现、生活质量及神经功能恢复情况。结果出院后研究组患者NIHSS评分优于常规组(t=26. 880,P=0. 000);出院半年后,研究组患者日常活动能力评分优于常规组(t=13. 503,P=0. 000)。出院时研究组患者对生活质量各指标评分均优于常规组(t=34. 760,P=0. 000; t=58. 450,P=0. 000; t=36. 089,P=0. 000; t=46. 533,P=0. 000)。结论对脑梗死患者提供氯吡格雷联合大剂量阿托伐他汀药物治疗,用药后可促进神经功能恢复,辅助早期康复锻炼可部分恢复患者活动能力,提高生活质量。
Ojbective To study the effect of clopidogrel combined with high dose atorvastatin on patients with cerebral infarction. Methods There were totally 106 cases of cerebral infarction patients in our hospital from Dec,2015 to Dec2017. According to different methods of treatment received,they were divided into the study group and the control group,53 cases in each. For patients in study group,clopidogrel combined with high dose atorvastatin therapy were prescribed; patients in control group received the routine dosage of atorvastatin treatment. Then we evaluated patients' mobility,quality of life and recovery level of neurological function. Results After discharge,the scores of the patients in the study group were better than those in the control group( t = 26. 880,P = 0. 000). At discharge,the scores on daily activities in the two groups were not statistically significant( t = 0. 038,P = 0. 970); Six months after discharge,the daily activity ability score of the study group was better than that of the control group( t = 26. 880,P = 0. 000). The patients in the study group were better than the control group in the quality of life indicators( t = 34. 760,P = 0. 000; t = 58. 450,P = 0. 000; t = 36. 089,P = 0. 000; t =46. 533,P = 0. 000). Conclusion Applying clopidogrel combined with high dose atorvastatin therapy on patients with cerebral infarction can promote the recovery of neurological function,and early rehabilitation exercise assistance activities in patients with partial recovery can improve the quality of life of patients.
Ojbective To study the effect of clopidogrel combined with high dose atorvastatin on patients with cerebral infarction. Methods There were totally 106 cases of cerebral infarction patients in our hospital from Dec,2015 to Dec2017. According to different methods of treatment received,they were divided into the study group and the control group,53 cases in each. For patients in study group,clopidogrel combined with high dose atorvastatin therapy were prescribed; patients in control group received the routine dosage of atorvastatin treatment. Then we evaluated patients' mobility,quality of life and recovery level of neurological function. Results After discharge,the scores of the patients in the study group were better than those in the control group( t = 26. 880,P = 0. 000). At discharge,the scores on daily activities in the two groups were not statistically significant( t = 0. 038,P = 0. 970); Six months after discharge,the daily activity ability score of the study group was better than that of the control group( t = 26. 880,P = 0. 000). The patients in the study group were better than the control group in the quality of life indicators( t = 34. 760,P = 0. 000; t = 58. 450,P = 0. 000; t = 36. 089,P = 0. 000; t =46. 533,P = 0. 000). Conclusion Applying clopidogrel combined with high dose atorvastatin therapy on patients with cerebral infarction can promote the recovery of neurological function,and early rehabilitation exercise assistance activities in patients with partial recovery can improve the quality of life of patients.
引文
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[12]张立,艾妮.氯吡格雷联合阿托伐他汀钙治疗短暂性脑缺血发作疗效观察[J].新乡医学院学报,2015,32(2):175-177.
[13]夏永梅,于玲,李兰君,等.阿托伐他汀联合氯吡格雷及拜阿司匹林对进展性脑梗死患者颈动脉粥样硬化的疗效评价[J].蚌埠医学院学报,2016,41(3):337-339.
[14]王经忠.氯吡格雷联合阿伐他汀治疗脑梗死的效果观察[J].中国实用神经疾病杂志,2016,19(19):82-83.
[15]TOMIZAWA Y,TANAKA R,SEKIGUCHI K,et al.Cerebral infarction in a case of Parry-Romberg syndrome[J].Journal of stroke and cerebrovascular diseases[J].J Stroke Cerebrovasc Dis,2014,23(2):393-394.
[16]张晓艳,沈建昀,张生,等.氯吡格雷联合阿托伐他汀对进展性脑梗死患者疗效及神经功能和生活质量的影响[J].解放军医药杂志,2017,29(11):26-29.
[2]张成刚,孙中武.阿托伐他汀钙联合氯吡格雷预防老年短暂性脑缺血发作患者脑梗死的效果及对血脂、血小板的影响[J].中国老年学杂志,2016,36(19):4759-4760.
[3]左朋,李方凤.阿司匹林联合氯吡格雷治疗脑梗死的临床效果研究[J].实用临床医药杂志,2015,19(11):119-120.
[4]陆伟恒,罗成宏,廖成钜,等.尤瑞克林联合阿司匹林对急性脑梗死患者血清学指标及临床疗效的影响[J].实用医学杂志,2017,33(21):3615-3618.
[5]李荣华,韦世友,管萍,等.氯吡格雷联合阿托伐他汀或瑞舒伐他汀用于脑梗死二级预防效果比较[J].山东医药,2017,57(12):83-85.
[6]张军武,李培育.早期联合应用氯吡格雷与丁苯酞注射液治疗脑梗死临床效果分析[J].中国急救医学,2016,36(z2):14-16.
[7]易兴阳,刘勇,林静,等.脑梗死患者氯吡格雷抵抗及其与90天时血管事件的相关性[J].中华老年心脑血管病杂志,2016,18(8):841-844.
[8]赵晓玲.瑞舒伐他汀联合氯吡格雷对脑梗死急性期患者血小板活化及聚集状态的影响[J].中国实用神经疾病杂志,2017,20(8):28-31.
[9]TAO X,LU W,DENG J G,et al.HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats[J].Neurol Res,2015,37(3):229-237.
[10]何丰.氟伐他汀联合氯吡格雷治疗脑梗死的疗效及对血浆内皮素与凝血系统的影响[J].中国实用神经疾病杂志,2016,19(20):11-13.
[11]朱敏真.短期强化内科治疗对前循环脑梗死二级预防的疗效分析[J].现代医院,2016,16(6):815-817,820.
[12]张立,艾妮.氯吡格雷联合阿托伐他汀钙治疗短暂性脑缺血发作疗效观察[J].新乡医学院学报,2015,32(2):175-177.
[13]夏永梅,于玲,李兰君,等.阿托伐他汀联合氯吡格雷及拜阿司匹林对进展性脑梗死患者颈动脉粥样硬化的疗效评价[J].蚌埠医学院学报,2016,41(3):337-339.
[14]王经忠.氯吡格雷联合阿伐他汀治疗脑梗死的效果观察[J].中国实用神经疾病杂志,2016,19(19):82-83.
[15]TOMIZAWA Y,TANAKA R,SEKIGUCHI K,et al.Cerebral infarction in a case of Parry-Romberg syndrome[J].Journal of stroke and cerebrovascular diseases[J].J Stroke Cerebrovasc Dis,2014,23(2):393-394.
[16]张晓艳,沈建昀,张生,等.氯吡格雷联合阿托伐他汀对进展性脑梗死患者疗效及神经功能和生活质量的影响[J].解放军医药杂志,2017,29(11):26-29.