伴有颅脑损伤对骨折患者血清中VEGF和TGF-β1水平影响研究
摘要
<正>外伤所致的骨折是骨科临床最常见的类型,部分病人常合并有颅脑损伤,临床实践中往往会观察到合并颅脑损伤的骨折患者骨痂出现过度生长,甚至有异位骨化的现象出现,有研究指出[1],骨折愈合时间和损伤组织修复速度与颅脑损伤相关,但与大脑损伤严重程度、颅内出血和性别等无关。体外实验证实[2],严重创伤性脑损伤患者血清能够加速人骨骼肌来源的细胞进行成骨分化和增殖,刺激间质
引文
[1]Yang TY,Wang TC,Tsai YH,et al.The effects of an injury to the brain on bone healing and callus formation in young adults with fractures of the femoral shaft[J].J Bone Joint Surg Br,2012,94(2):227.
[2]Cadosch D,Toffoli AM,Gautschi OP,et al.Serum after traumatic brain injury increases proliferation and supports expression of osteoblast markers in muscle cells[J].J Bone Joint Surg Am,2010,92(3):645.
[3]宋昭君,倪卫东,高仕长.丹参注射液对骨折愈合过程中BMP-7、TGF-β1及bFGF表达的影响[J].第三军医大学学报,2013,35(3):223.
[4]Dirckx N,Van Hul M,Maes C.Osteoblast recruitment to sites of bone formation in skeletal development,homeostasis,and regeneration[J].Birth Defects Res C Embryo Today,2013,99(3):170.
[5]Wang CJ,Yang KD,Ko JY,et al.The effects of shockwave on bone healing and systemic concentrations of nitric oxide(NO),TGF-beta1,VEGF and BMP-2in long bone non-unions[J].Nitric Oxide,2009,20(4):298.
[6]Lee CM,Kim EM,Cheong SJ,et al.Targeted molecular imaging of VEGF receptors overexpressed in ischemic microvasculature using chitosan-DC101conjugates[J].J Biomed Mater Res A,2010,92(4):1510.
[7]Kttstorfer J,Kaiser G,Thomas A,et al.The influence of non-osteogenic factors on the expression of M-CSF and VEGF during fracture healing[J].Injury,2013,44(7):930.
[8]Aho OM,Lehenkari P,Ristiniemi J,et al.The mechanism of action of induced membranes in bone repair[J].J Bone Joint Surg Am,2013,95(7):597.
[9]Bosco P,Ferri R,Salluzzo MG,et al.Role of the TransformingGrowth-Factor-β1Gene in Late-Onset Alzheimer's Disease:Implications for the Treatment[J].Curr Genomics,2013,14(2):147.
[10]Souza TF,Andrade AL,Ferreira GT,et al.Healing and expression of growth factors(TGF-βand PDGF)in canine radial ostectomy gap containing platelet-rich plasma[J].Vet Comp Orthop Traumatol,2012,25(6):445.
[11]Estai MA,Suhaimi F,Das S,et al.Expression of TGF-β1in the blood during fracture repair in an estrogen-deficient rat model[J].Clinics(Sao Paulo),2011,66(12):2113.
[12]徐攀峰,邵金祥,张维康.成纤维细胞生长因子2和转化生长因子-β1在四肢骨折愈合过程中表达调控的研究[J].中国基层医药,2013,20(23):3555.
[2]Cadosch D,Toffoli AM,Gautschi OP,et al.Serum after traumatic brain injury increases proliferation and supports expression of osteoblast markers in muscle cells[J].J Bone Joint Surg Am,2010,92(3):645.
[3]宋昭君,倪卫东,高仕长.丹参注射液对骨折愈合过程中BMP-7、TGF-β1及bFGF表达的影响[J].第三军医大学学报,2013,35(3):223.
[4]Dirckx N,Van Hul M,Maes C.Osteoblast recruitment to sites of bone formation in skeletal development,homeostasis,and regeneration[J].Birth Defects Res C Embryo Today,2013,99(3):170.
[5]Wang CJ,Yang KD,Ko JY,et al.The effects of shockwave on bone healing and systemic concentrations of nitric oxide(NO),TGF-beta1,VEGF and BMP-2in long bone non-unions[J].Nitric Oxide,2009,20(4):298.
[6]Lee CM,Kim EM,Cheong SJ,et al.Targeted molecular imaging of VEGF receptors overexpressed in ischemic microvasculature using chitosan-DC101conjugates[J].J Biomed Mater Res A,2010,92(4):1510.
[7]Kttstorfer J,Kaiser G,Thomas A,et al.The influence of non-osteogenic factors on the expression of M-CSF and VEGF during fracture healing[J].Injury,2013,44(7):930.
[8]Aho OM,Lehenkari P,Ristiniemi J,et al.The mechanism of action of induced membranes in bone repair[J].J Bone Joint Surg Am,2013,95(7):597.
[9]Bosco P,Ferri R,Salluzzo MG,et al.Role of the TransformingGrowth-Factor-β1Gene in Late-Onset Alzheimer's Disease:Implications for the Treatment[J].Curr Genomics,2013,14(2):147.
[10]Souza TF,Andrade AL,Ferreira GT,et al.Healing and expression of growth factors(TGF-βand PDGF)in canine radial ostectomy gap containing platelet-rich plasma[J].Vet Comp Orthop Traumatol,2012,25(6):445.
[11]Estai MA,Suhaimi F,Das S,et al.Expression of TGF-β1in the blood during fracture repair in an estrogen-deficient rat model[J].Clinics(Sao Paulo),2011,66(12):2113.
[12]徐攀峰,邵金祥,张维康.成纤维细胞生长因子2和转化生长因子-β1在四肢骨折愈合过程中表达调控的研究[J].中国基层医药,2013,20(23):3555.