恶性肿瘤血液高凝状态的中医药治疗
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摘要
恶性肿瘤患者尤其是中晚期患者存在普遍的高凝状态,高凝状态可以促进肿瘤转移、引起静脉血栓栓塞症等一系列并发症,是引起肿瘤患者死亡的重要因素。导致高凝状态的中医病因病机包括因虚致瘀、因实致瘀、因毒致瘀及出血致瘀。针对肿瘤患者高凝状态的中医治疗方法包括中药汤药治疗、中成药及中药注射液治疗及针灸治疗,对恶性肿瘤高凝状态的中医药干预治疗进行简要评述。
High coagulation is common in patients with malignant tumors,especially in patients with middle and advanced stage tumors. High coagulation can promote tumor metastasis and cause a series of complications such as venous thromboembolism,which are important factors leading to the death of tumor patients. The traditional Chinese medicine( TCM) etiology and pathogenesis that leading to high coagulation include blood stasis due to deficiency,blood stasis due to excess,blood stasis due to toxicity,blood stasis due to bleeding. The TCM treatment for high coagulation of tumor patients includes TCM decoction treatment,Chinese patent medicine,TCM injection and acupuncture. This paper briefly reviewed the TCM intervention treatment of high coagulation state of malignant tumor.
High coagulation is common in patients with malignant tumors,especially in patients with middle and advanced stage tumors. High coagulation can promote tumor metastasis and cause a series of complications such as venous thromboembolism,which are important factors leading to the death of tumor patients. The traditional Chinese medicine( TCM) etiology and pathogenesis that leading to high coagulation include blood stasis due to deficiency,blood stasis due to excess,blood stasis due to toxicity,blood stasis due to bleeding. The TCM treatment for high coagulation of tumor patients includes TCM decoction treatment,Chinese patent medicine,TCM injection and acupuncture. This paper briefly reviewed the TCM intervention treatment of high coagulation state of malignant tumor.
引文
[1]王静,张侠.恶性肿瘤患者高凝状态的危险因素、发生机制及实验室检测[J].检验医学与临床,2015,12(15):2284-3387.
[2]HEIT JA,O F'FALLON WM,PETTERSON TM,et al.Relativer impact of risk factors for deep vein thrombosis and pulmonary embolism:a population-based study[J]. Arch Intern Med,2002,162(11):1245-1248.
[3]FRANCIS CW. Clinical practice. Prophylaxis for thromboembolism in hospitalized medical patients[J]. N EngI J Med,2007,356(14):1438-1444.
[4]AHMAD SANSARI AA. Therapeutic roles of heparin anticoagulants in cancer and related disorders[J]. Med Chem,2011,7(5):504-517.
[5]郭英华.恶性肿瘤患者与血栓症[J].中华肿瘤防治杂志,2006,13(11):875-878.
[6]蒋大鹏,工凯,蒋鹤生,等.新型口服抗凝药不良反应发生因素及应对策略[J].解放军医药杂志,2017,29(4):113-116.
[7]许靖.基于中医瘀血理论的针刺治疗肿瘤高凝状态的临床研究[D].合肥:安徽中医药大学,2017.
[8]宇明慧,姚云祥,张涛.益气活血方加减改善妇科恶性肿瘤患者高凝状态临床观察[J].安徽中医药大学学报,2018,37(4):16-19.
[9]肖玉帛.中西医结合治疗改善晚期恶性肿瘤高凝状态的临床观察[J].数理医药杂志,2015,28(6):824-825.
[10]郑洋.芪龙颗粒、芪蛭颗粒治疗非小细胞肺癌高凝状态的比较性研究[D].北京:北京中医药大学,2014:1-2.
[11]张清.疏肝法治疗肝郁型子宫颈癌同步放化疗后的临床观察[D].哈尔滨:黑龙江中医药大学,2016:2.
[12]李超,樊巧玲.从“毒邪”论治恶性肿瘤[J].山西中医学院学报,2012,13(3):134-135.
[13]郑洋,孙霈,董青,等.恶性肿瘤血液高凝状态中医治疗思路与方法[J].中医肿瘤,2013,22(12):1011-1014.
[14]李红梅.石棉致癌研究进展[C]//中华预防医学会劳动卫生与职业病分会.第十三次全国劳动卫生与职业病学术会议论文汇编.泰安:中华预防医学会劳动卫生与职业病分会,2014:1.
[15]王建玲,杨嘉,宋玉良.化疗对晚期非小细胞肺癌患者凝血四项的影响[J].现代肿瘤医学,2015,23(17):2440-2442.
[16]但刚,江忠勇,刘媛,等.肺癌患者放化疗后血小板聚集功能的变化观察[J].检验医学与临床,2015,12(8):1030-1031.
[17]李小霞.探讨手术患者凝血功能指标监测变化的临床意义[J].中国医学创新,2014,11(29):143-146.
[18]THORSON CM,VAN HAREN RM,RYAN ML,et al.Persistence of hypercoagulable state after resection of intra-abdominal malignancies[J]. J Am Coll Surg,2013,216(4):580-589.
[19]胡艳,侯安继,周莉,等.益气活血方对中晚期恶性肿瘤高凝状态的影响[J].上海中医药杂志,2011,45(8):36-38.
[20]蔡格,曾松林,吴玉华.活血化瘀法治疗恶性肿瘤高凝状态30例临床观察[J].湖南中医杂志,2018,34(3):8-10.
[21]张红,李媛,廖淑芬.抗肿瘤常规方案联合血府逐瘀汤治疗中晚期非小细胞肺癌血液高凝状态30例[J].湖南中医杂志,2018,34(6):67-68.
[22]方汉钦,魏开建.魏开建对肿瘤血瘀证的认识及治疗经验[J].中医药临床杂志,2018,30(2):247-249.
[23]唐莉,段巧虹,范平生.水蛙治疗恶性肿瘤高凝状态临床研究[J].中医药临床杂志,2012,24(9):871-872.
[24]蔡玉梅,牛雪娇,崔宇,等.血府逐瘀胶囊治疗恶性肿瘤高凝状态的临床观察[J].天津医药,2014,42(1):78-79.
[25]施怡,朱陵群,陈信义,等.新加良附颗粒治疗Ⅲ/Ⅳ期胃癌合并血液高凝状态临床研究[J].中华中医药杂志,2017,32(11):5224-5229.
[26]梁倩倩.消癌平注射液对中晚期肿瘤化疗患者凝血功能影响的临床研究[D].北京:北京中医药大学,2016:1-2.
[27]王生,赵阳,陶丽,等.川芎嗪对肿瘤介导的血液高凝的影响[J].中国药理学通报,2012,28(5):709-715.
[28]任闽山,黄珊珊,郭文秀.灯盏细辛注射液改善恶性肿瘤高凝状态的作用及机制分析[J].实用临床医药杂志,2013,17(14):62-64.
[29]刘红.麦粒灸治疗恶性肿瘤高凝状态的疗效分析与机制探讨[D].南京:南京中医药大学,2017:4.
[2]HEIT JA,O F'FALLON WM,PETTERSON TM,et al.Relativer impact of risk factors for deep vein thrombosis and pulmonary embolism:a population-based study[J]. Arch Intern Med,2002,162(11):1245-1248.
[3]FRANCIS CW. Clinical practice. Prophylaxis for thromboembolism in hospitalized medical patients[J]. N EngI J Med,2007,356(14):1438-1444.
[4]AHMAD SANSARI AA. Therapeutic roles of heparin anticoagulants in cancer and related disorders[J]. Med Chem,2011,7(5):504-517.
[5]郭英华.恶性肿瘤患者与血栓症[J].中华肿瘤防治杂志,2006,13(11):875-878.
[6]蒋大鹏,工凯,蒋鹤生,等.新型口服抗凝药不良反应发生因素及应对策略[J].解放军医药杂志,2017,29(4):113-116.
[7]许靖.基于中医瘀血理论的针刺治疗肿瘤高凝状态的临床研究[D].合肥:安徽中医药大学,2017.
[8]宇明慧,姚云祥,张涛.益气活血方加减改善妇科恶性肿瘤患者高凝状态临床观察[J].安徽中医药大学学报,2018,37(4):16-19.
[9]肖玉帛.中西医结合治疗改善晚期恶性肿瘤高凝状态的临床观察[J].数理医药杂志,2015,28(6):824-825.
[10]郑洋.芪龙颗粒、芪蛭颗粒治疗非小细胞肺癌高凝状态的比较性研究[D].北京:北京中医药大学,2014:1-2.
[11]张清.疏肝法治疗肝郁型子宫颈癌同步放化疗后的临床观察[D].哈尔滨:黑龙江中医药大学,2016:2.
[12]李超,樊巧玲.从“毒邪”论治恶性肿瘤[J].山西中医学院学报,2012,13(3):134-135.
[13]郑洋,孙霈,董青,等.恶性肿瘤血液高凝状态中医治疗思路与方法[J].中医肿瘤,2013,22(12):1011-1014.
[14]李红梅.石棉致癌研究进展[C]//中华预防医学会劳动卫生与职业病分会.第十三次全国劳动卫生与职业病学术会议论文汇编.泰安:中华预防医学会劳动卫生与职业病分会,2014:1.
[15]王建玲,杨嘉,宋玉良.化疗对晚期非小细胞肺癌患者凝血四项的影响[J].现代肿瘤医学,2015,23(17):2440-2442.
[16]但刚,江忠勇,刘媛,等.肺癌患者放化疗后血小板聚集功能的变化观察[J].检验医学与临床,2015,12(8):1030-1031.
[17]李小霞.探讨手术患者凝血功能指标监测变化的临床意义[J].中国医学创新,2014,11(29):143-146.
[18]THORSON CM,VAN HAREN RM,RYAN ML,et al.Persistence of hypercoagulable state after resection of intra-abdominal malignancies[J]. J Am Coll Surg,2013,216(4):580-589.
[19]胡艳,侯安继,周莉,等.益气活血方对中晚期恶性肿瘤高凝状态的影响[J].上海中医药杂志,2011,45(8):36-38.
[20]蔡格,曾松林,吴玉华.活血化瘀法治疗恶性肿瘤高凝状态30例临床观察[J].湖南中医杂志,2018,34(3):8-10.
[21]张红,李媛,廖淑芬.抗肿瘤常规方案联合血府逐瘀汤治疗中晚期非小细胞肺癌血液高凝状态30例[J].湖南中医杂志,2018,34(6):67-68.
[22]方汉钦,魏开建.魏开建对肿瘤血瘀证的认识及治疗经验[J].中医药临床杂志,2018,30(2):247-249.
[23]唐莉,段巧虹,范平生.水蛙治疗恶性肿瘤高凝状态临床研究[J].中医药临床杂志,2012,24(9):871-872.
[24]蔡玉梅,牛雪娇,崔宇,等.血府逐瘀胶囊治疗恶性肿瘤高凝状态的临床观察[J].天津医药,2014,42(1):78-79.
[25]施怡,朱陵群,陈信义,等.新加良附颗粒治疗Ⅲ/Ⅳ期胃癌合并血液高凝状态临床研究[J].中华中医药杂志,2017,32(11):5224-5229.
[26]梁倩倩.消癌平注射液对中晚期肿瘤化疗患者凝血功能影响的临床研究[D].北京:北京中医药大学,2016:1-2.
[27]王生,赵阳,陶丽,等.川芎嗪对肿瘤介导的血液高凝的影响[J].中国药理学通报,2012,28(5):709-715.
[28]任闽山,黄珊珊,郭文秀.灯盏细辛注射液改善恶性肿瘤高凝状态的作用及机制分析[J].实用临床医药杂志,2013,17(14):62-64.
[29]刘红.麦粒灸治疗恶性肿瘤高凝状态的疗效分析与机制探讨[D].南京:南京中医药大学,2017:4.