摘要
目的研究滋肾益髓针法联合复方麝香注射液治疗脑卒中后认知障碍的临床效果。方法选取2015年6月—2016年6月在乐亭县医院就诊的脑卒中后认知障碍患者110例,根据治疗方式不同分为对照组和联合组,对照组患者给予20 mL复方麝香注射液溶于5%的葡萄糖,进行静脉滴注治疗,1次/d,联合组在对照组治疗的基础上进行滋肾益髓针法治疗,2组连续治疗3周。统计中医证候积分、巴氏指数评分(Barthel评分)、蒙特利尔认知评估量表(montreal cognitive assessment,MoCA)积分、格拉斯哥昏迷评分(glasgow coma scale,GCS)及脑血肿量,统计2组不良反应。结果治疗后,联合组面色(t=21.080,P<0.001)、乏力(t=20.340,P<0.001)、精神疲惫(t=20.880,P<0.001)、头晕(t=22.510,P<0.001)中医证候积分均低于对照组,差异有统计学意义(均P<0.05)。治疗后联合组Barthel评分(t=6.490,P<0.001)、MoCA积分(t=10.130,P<0.001)高于对照组;治疗后联合组脑血肿量低于对照组(t=6.490,P<0.001),GCS评分高于对照组(t=10.130,P<0.001)。联合组不良反应发生率为3.64%,低于对照组的14.55%。结论滋肾益髓针法联合复方麝香注射液治疗脑卒中后认知障碍效果显著,可以改善患者中医证候和认知功能水平,促进患者恢复。
Objective To study the effect of kidney-nourishing needle combined with compound musk injection on cognitive impairment after stroke. Methods A total of 110 patients with post-stroke cognitive impairment who visited our hospital from June 2015 to June 2016 were selected. They were divided into control group and combined group according to different treatments. The patients in the control group were treated with 20 ml compound musk injection dissolved in 5% glucose and intravenous drip once a day. The patients in the combined group were treated with nourishing kidney and benefiting marrow acupuncture on the basis of the treatment in the control group. The two groups were treated continuously for 3 weeks. Statistical data included TCM syndrome score, Barthel score, Montreal Cognitive Assessment(MoCA) score, Glasgow Coma Scale(GCS), cerebral hematoma volume and adverse reactions. Results After treatment, the scores of TCM syndromes in the combined group(t=21.080, P<0.001), fatigue(t=20.340, P<0.001), mental fatigue(t=20.880, P<0.001), dizziness(t=22.510, P<0.001) were lower than those in the control group(all P<0.05). After treatment, the Barthel score(t =6.490, P<0.001), MoCA score(t=10.130, P<0.001) in the combined group were higher than those in the control group. The amount of cerebral hematoma in the combined group was lower than that in the control group(t=6.490, P<0.001), and the GCS score was higher than that in the control group(t=10.130, P<0.001). The incidence of adverse reactions in the combined group was 3.64%, lower than 14.55% in the control group. Conclusion The combination of kidney-nourishing needle therapy with compound musk injection has a significant effect on cognitive impairment after stroke, which can improve the level of TCM syndromes and cognitive functions and promote the recovery of patients.
引文
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