复方米非司酮配伍米索前列醇在中孕引产治疗中的临床观察
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摘要
目的:探讨研究复方米非司酮配伍米索前列醇在中孕引产治疗中的临床效果。方法:将于宜春市袁州区妇幼保健院行中孕引产的孕妇中抽取60例,将其分成观察、对照两组。其中,对照组选择利凡诺作治疗药物,观察组选择复方米非司酮配伍米索前列醇作治疗方案,比较两组孕妇的临床效果。结果:观察组引产时间及出血量均优于对照组对应值;观察组引产成功、胎盘胎膜完全娩出率及清宫率均优于对照组对应值(93.33%>70.00%、90.00%>63.33%、3.33%<33.33%),且P<0.05。结论:针对中孕引产孕妇选择复方米非司酮配伍米索前列醇进行治疗,是有效缩短产妇出血量及引产时间的有效措施,对提高其引产成功率、胎盘胎膜完全娩出率具有较好的临床价值,以此减少产妇清宫情况,预后改善效果显著,值得临床上大力推广。
Objective: To study the clinical effect of compound mifepristone combined with misoprostol in the treatment of induced labor in middle pregnancy. Methods: 60 cases of induced labor in our hospital were divided into observation group and control group. The control group was treated with rivanol and the observation group with compound mifepristone and misoprostol. Results: The time of induced labor and the amount of blood loss in the observation group were better than those in the control group, and the rate of complete delivery of placental membranes and the rate of uterine clearing in the observation group were better than those in the control group(93.33%>70.00%、90.00%>63.33%, 3.33%<33.33%), and P<0.05. Conclusion: The combination of mifepristone and misoprostol is an effective measure to shorten the amount of blood loss and induce labor, and improve the success rate of induced labor. The rate of complete placental membrane delivery is of good clinical value, which can reduce the condition of the uterus and improve the prognosis. Thus it is worth popularizing in clinic.
Objective: To study the clinical effect of compound mifepristone combined with misoprostol in the treatment of induced labor in middle pregnancy. Methods: 60 cases of induced labor in our hospital were divided into observation group and control group. The control group was treated with rivanol and the observation group with compound mifepristone and misoprostol. Results: The time of induced labor and the amount of blood loss in the observation group were better than those in the control group, and the rate of complete delivery of placental membranes and the rate of uterine clearing in the observation group were better than those in the control group(93.33%>70.00%、90.00%>63.33%, 3.33%<33.33%), and P<0.05. Conclusion: The combination of mifepristone and misoprostol is an effective measure to shorten the amount of blood loss and induce labor, and improve the success rate of induced labor. The rate of complete placental membrane delivery is of good clinical value, which can reduce the condition of the uterus and improve the prognosis. Thus it is worth popularizing in clinic.
引文
[1]赵秀梅,赵秀伟,邸霞,等.欣普贝生与米索前列醇用于促宫颈成熟及引产的效果比较[J].中国妇幼保健, 2012, 27(05):762-763.
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[10]李雪媛,劳力,张映辉,等.地诺前列酮栓用于不同宫颈条件孕产妇引产疗效及安全性研究[J].中国实用妇科与产科杂志, 2017, 33(06):626-631.
[11]陈怡君,张丹,龚晋,等.瘢痕子宫合并前壁胎盘完全性胎盘前置状态中期妊娠引产方式探讨[J].实用妇产科杂志, 2013, 29(05):370-372.
[12]王新茹,胡晓燕.米非司酮联合米索前列醇在瘢痕子宫中期引产中的疗效分析[J].中国妇产科临床杂志, 2015, 16(02):167-168.
[13]李骐含,乔宠,杨小梅,等.剖宫产术后瘢痕子宫妊娠中晚期引产方式探讨[J].中国实用妇科与产科杂志, 2014, 30(06):462-465.
[14]刘海艳,陈寒,李智.米索前列醇晚期引产的临床研究[J].中国临床药理学杂志, 2015, 31(21):2108-2110+2169.
[15]李雪媛,郭跃文,许燕文,等.孕晚期地诺前列酮栓引产的临床疗效及安全性:多中心回顾性分析[J].南方医科大学学报, 2017, 37(01):18-23.
[2]陈英,刘琼辉.利凡诺配伍米非司酮、米索前列醇用于中孕引产的临床观察[J].重庆医学, 2012, 41(05):517+520.
[3]苏继颖,杨华,梁致怡,等.妊娠中期孕妇中央性前置胎盘的诊断及引产方法(附69例分析)[J].山东医药, 2017, 57(03):58-60.
[4]钱金凤,黄紫蓉.中期妊娠引产方法评估及选择[J].中国实用妇科与产科杂志, 2012, 28(09):654-657.
[5]罗蒲英,熊员焕,凌燕.持续硬膜外麻醉用于中孕引产镇痛的效果及安全性观察[J].广东医学, 2014, 35(23):3720-3722.
[6]宁丰,韦凤莲,林红.欣普贝生用于妊娠期高血压疾病引产的临床观察[J].实用医学杂志, 2013, 29(18):3048-3050.
[7]刘喆,杨慧霞.规范使用催引产技术促进自然分娩[J].实用妇产科杂志,2015, 31(04):251-253.
[8]蔡彦卿,徐亮,张丹丹.α-MSH、IL-6和NF-κB在晚期流产和早产中的表达及意义[J].现代妇产科进展, 2015, 24(06):448-450.
[9]屈在卿,马润玫,杜明钰,等.剖宫产瘢痕子宫妊娠孕中期引产方法的探讨[J].实用妇产科杂志, 2016, 32(01):77-79.
[10]李雪媛,劳力,张映辉,等.地诺前列酮栓用于不同宫颈条件孕产妇引产疗效及安全性研究[J].中国实用妇科与产科杂志, 2017, 33(06):626-631.
[11]陈怡君,张丹,龚晋,等.瘢痕子宫合并前壁胎盘完全性胎盘前置状态中期妊娠引产方式探讨[J].实用妇产科杂志, 2013, 29(05):370-372.
[12]王新茹,胡晓燕.米非司酮联合米索前列醇在瘢痕子宫中期引产中的疗效分析[J].中国妇产科临床杂志, 2015, 16(02):167-168.
[13]李骐含,乔宠,杨小梅,等.剖宫产术后瘢痕子宫妊娠中晚期引产方式探讨[J].中国实用妇科与产科杂志, 2014, 30(06):462-465.
[14]刘海艳,陈寒,李智.米索前列醇晚期引产的临床研究[J].中国临床药理学杂志, 2015, 31(21):2108-2110+2169.
[15]李雪媛,郭跃文,许燕文,等.孕晚期地诺前列酮栓引产的临床疗效及安全性:多中心回顾性分析[J].南方医科大学学报, 2017, 37(01):18-23.