香青兰对慢性高原病模型大鼠的改善作用
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摘要
目的探讨香青兰对慢性高原病模型大鼠的改善作用。方法 100只SD大鼠随机分为对照组、模型组、硝苯地平组、香青兰水提组、香青兰醇提组,每组20只。除对照组外,其他4组共80只大鼠建立慢性高原病模型,连续造模30 d后,4组分别给予蒸馏水0.4 ml,硝苯地平2.7 mg/kg,香青兰水提物0.4 ml,香青兰醇提物0.4 ml,对照组给予蒸馏水0.4 ml。连续干预15 d后,测定肺动脉压(pulmonary arterial pressure, PAP)、颈动脉压(carotid arterial pressure, CAP)、血清学指标[内皮素-1(ET-1)、血管内皮生长因子(vascular endothelial growth factor, VEGF)、高同型半胱氨酸(homocystein?emia, Hcy)、一氧化氮(NO)]、血常规、血气分析。结果香青兰水提物可降低模型组大鼠血清中ET-1、Hcy、VEGF、Hb、HCT含量,升高NO、SpO2和PaO2(P<0.05)。香青兰醇提物可以有效改善除SpO2和PaO2之外的所有指标(P<0.05)。结论香青兰对慢性高原病具有一定的改善作用。
引文
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[2]单莲莲,迪丽努尔·买买提依明,是文辉,等.厄贝沙坦对慢性高原病大鼠肺组织损伤的改善作用[J].北京医学,2015,37:358-362.
[3]夏克尔江·苏来曼,高振,迪丽努尔·买买提依明,等.三磷酸腺苷二钠对慢性高原病大鼠肝脏保护作用[J].科技导报,2015,33:113-119.
[4]Maimaitiyiming D,Hu GM,Aikemu A,et al.The treatment of Uygur medicine Dracocephalum moldavica L on chronic mountain sickness rat model[J].Pharmacogn Mag,2014,10:477-482.
[5]杨彩玉,安希文,付伟,等.香青兰总黄酮对大鼠离体胸主动脉的舒张作用[J].生物物理学报,2010,26:334-340.
[6]Morgan SL,Baggott JE.Folate supplementation during methotrexate therapy for rheumatoid arthritis[J].Clin Exp Rheumatol,2010,28:S102-S109.
[7]Qin X,Huo Y,Langman CB,et al.Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease:a meta-analysis[J].Clin J Am Soc Nephrol,2011,6:482-488.
[8]F?rstermann U,Münzel T.Endothelial nitric oxide synthase in vascular disease:from marvel to menace[J].Circulation,2006,13:1708-1714.
[9]李明.血清同型半胱氨酸、血浆内皮素-1、B型利钠肽及D-二聚体联合检测对急性脑梗死的诊断价值[J].实用临床医药杂志,2015,19:23-25.
[10]哈玲梅,董化江,单娜娜,等.天麻素对心肌缺血再灌注损伤大鼠血清内皮素-1水平的影响[J].新乡医学院学报,2015,32:395-397.
[11]Yang RX,Huang SY,Yan FF,et al.Danshensu protects vascular endothelia in a rat model of hyperhomocysteinemia[J].Acta Pharmacol Sin,2010,31:1395-1400.
[12]Winchester L,Veeranki S,Givvimani S,et al.Exercise mitigates the adverse effects of hyperhomocysteinemia on macrophages,MMP-9,skeletal muscle,and white adipocytes[J].Can J Physiol Pharmacol,2014,92:575-582.