肠道免疫-慢性炎症与胰岛素抵抗及中医药治疗研究进展
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摘要
慢性炎症是胰岛素抵抗(IR)发生的根本原因。越来越多的证据表明,肠道免疫-慢性炎症是IR发生的重要因素之一,但其机制尚不完全清楚。近年来研究发现,中医药通过调节肠道免疫改善IR具有良好的疗效,且安全可靠。文章通过对肠道免疫-慢性炎症影响IR的相关机制及中医药研究现状进行总结,并提出中医药改善IR的研究方向。
Chronic inflammation is primary cause of insulin resistance(IR). Growing evidence has implicated the intestinal immune-chronic inflammation as an important contributor to IR while its mechanism is not clear. In recent years, studies have manifested that traditional Chinese medicine has a practicable and safe therapeutic effect in the treatment of reducing IR through the regulation of intestinal immunity system. This review made a conclusion about mechanism of intestinal immunitychronic inflammation affecting IR and current situation of traditional Chinese medicine, and proposed the research direction of traditional Chinese medicine to relieve IR.
Chronic inflammation is primary cause of insulin resistance(IR). Growing evidence has implicated the intestinal immune-chronic inflammation as an important contributor to IR while its mechanism is not clear. In recent years, studies have manifested that traditional Chinese medicine has a practicable and safe therapeutic effect in the treatment of reducing IR through the regulation of intestinal immunity system. This review made a conclusion about mechanism of intestinal immunitychronic inflammation affecting IR and current situation of traditional Chinese medicine, and proposed the research direction of traditional Chinese medicine to relieve IR.
引文
[1]Hotamisligil G S,Shargill N S,Spiegelman B M.Adipose expression of tumor necrosis factor-alpha:Direct role in obesity-linked insulin resistance.Science,1993,259(5091):87-91
[2]Magalhaes I,Pingris K,Poitou C,et al.Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients.J Clin Invest,2015,125(4):1752-1762
[3]Winer D A,Winer S,Dranse H J,et al.Immunologic impact of the intestine in metabolic disease.Journal of Clinical Investigation,2017,127(1):33-42
[4]Winer D A,Luck H,Tsai S,et al.The intestinal immune system in obesity and insulin resistance.Cell Metab,2016,23(3):413-426
[5]Cani P D,Bibiloni R,Knauf C,et al.Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.Diabetes,2008,57(6):1470-1481
[6]Luck H,Tsai S,Chung J,et al.Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.Cell Metab,2015,21(4):527-542
[7]Al-Sadi R M,Ma T Y.IL-1 causes an increase in intestinal epithelial tight junction permeability.The Journal of Immunology,2007,178(7):4641-4649
[8]Wang X,Ota N,Manzanillo P,et al.Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes.Nature,2014,514(7521):237-241
[9]Cario E,Rosenberg I M,Brandwein S L,et al.Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors.J Immunol,2000,164(2):966-972
[10]Furi I,Sipos F,Germann T M,et al.Epithelial toll-like receptor 9signaling in colorectal inflammation and cancer:Clinico-pathogenic aspects.World J Gastroenterol,2013,19(26):4119-4126
[11]Peterson L W,Artis D.Intestinal epithelial cells:Regulators of barrier function and immune homeostasis.Nat Rev Immunol,2014,14(3):141-153
[12]Pendyala S,Neff L M,Suarez-Farinas M,et al.Diet-induced weight loss reduces colorectal inflammation:implications for colorectal carcinogenesis.Am J Clin Nutr,2011,93(2):234-242
[13]Ding S,Chi M M,Scull B P,et al.High-fat diet:Bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.Plos One,2010,5(8):e12191
[14]Johnson A M,Costanzo A,Gareau M G,et al.High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability.PLo S One,2015,10(4):e122195
[15]Helen,Tsai,Sue,et al.Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.Agents,2015,21(4):527-542
[16]Monteiro-Sepulveda M,Touch S,Mendes-SáC,et al.Jejunal T cell inflammation in human obesity correlates with decreased enterocyte insulin signaling.Cell Metabolism,2015,22(1):113-124
[17]Neuman H,Debelius J W,Knight R,et al.Microbial endocrinology:The interplay between the microbiota and the endocrine system.FEMS Microbiology Reviews,2015,39(4):509-521
[18]Hall J A,Bouladoux N,Sun C M,et al.Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses.Immunity,2008,29(4):637-649
[19]Ries M,Schuster P,Thomann S,et al.Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation.J Leukoc Biol,2013,94(1):123-135
[20]Bouladoux N,Hall J A,Grainger J R,et al.Regulatory role of suppressive motifs from commensal DNA.Mucosal Immunol,2012,5(6):623-634
[21]Elce A,Amato F,Zarrilli F,et al.Butyrate modulating effects on proinflammatory pathways in human intestinal epithelial cells.Benef Microbes,2017,8(5):841-847
[22]Davis-Richardson A G,Triplett E W.A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes.Diabetologia,2015,58(7):1386-1393
[23]Honda K,Littman D R.The microbiome in infectious disease and Inflammation.Annual Review of Immunology,2012,30(1):759-795
[24]邵加庆.代谢性疾病防控的新大陆——肠道菌群.医学研究生报,2016,29(1):16-20
[25]Zhao L,Cen F,Tian F,et al.Combination treatment with quercetin and resveratrol attenuates high fat diet-induced obesity and associated inflammation in rats via the AMPKalpha1/SIRT1signaling pathway.Exp Ther Med,2017,14(6):5942-5948
[26]Bai J,Zhu Y,Dong Y.Response of gut microbiota and inflammatory status to bitter melon(Momordica charantia L.)in high fat diet induced obese rats. J Ethnopharmacol,2016,194:717-726
[27]Vazquez-Prieto M A,Bettaieb A,Haj F G,et al.(-)-Epicatechin prevents TNFalpha-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1adipocytes.Arch Biochem Biophys,2012,527(2):113-118
[28]Xu J H,Liu X Z,Pan W,et al.Berberine protects against dietinduced obesity through regulating metabolic endotoxemia and gut hormone levels.Mol Med Rep,2017,15(5):2765-2787
[29]Ye L,Liang S,Guo C,et al.Inhibition of M1 macrophage activation in adipose tissue by berberine improves insulin resistance.Life Sci,2016,166:82-91
[30]Wei Y,Gao J,Qin L,et al.TanshinoneⅠalleviates insulin resistance in type 2 diabetes mellitus rats through IRS-1 pathway.Biomed Pharmacother,2017,93:352-358
[31]Lou T,Zhang Z,Xi Z,et al.Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes.Inflammation,2011,34(6):659-667
[32]王超,张会欣,邢邯英,等.氧化苦参碱抑制p38MAPK通路减轻高脂喂养胰岛素抵抗小鼠氧化应激.中国中药杂志,2016,41(15):2872-2876
[33]Yang S J,Choi J M,Park S E,et al.Preventive effects of bitter melon(Momordica charantia)against insulin resistance and diabetes are associated with the inhibition of NF-kappa B and JNK pathways in high-fat-fed OLETF rats.J Nutr Biochem,2015,26(3):234-240
[34]Yang X,Li L,Fang K,et al.Wu-Mei-Wan reduces insulin resistance via inhibition of NLRP3 inflammasome activation in HepG2 cells.Evid Based Complement Alternat Med,2017,2017:7283241
[35]Jiang C,Yao N,Wang Q,et al.Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice.J Ethnopharmacol,2014,153(2):344-351
[36]侯丽琼,赵铁耘,张伊祎.黄连素对肥胖胰岛素抵抗大鼠骨骼肌胰岛素抵抗的干预研究.四川大学学报(医学版),2015,46(6):827-831
[37]Chang W,Chen L,Hatch G M.Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes.Biochim Biophys Acta,2016,1861(4):352-362
[38]Zhao L,Zhang Q,Ma W,et al.A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota.Food Funct,2017,8(12):4644-4656
[39]Wang J H,Kim B S,Han K,et al.Ephedra-Treated Donor-Derived Gut Microbiota Transplantation Ameliorates High Fat Diet-Induced Obesity in Rats.Int J Environ Res Public Health,2017,14(6):555
[40]Wang W,Zhao J,Gui W,et al.Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with nonalcoholic fatty liver disease.Br J Pharmacol,2018,175(3):469-484
[41]章常华,马广强,邓永兵,等.葛根芩连汤对KK-Ay糖尿病小鼠血浆中LPS、TNF-α、IL-6及肠道菌群的影响.中草药,2017,48(8):1611-1616
[2]Magalhaes I,Pingris K,Poitou C,et al.Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients.J Clin Invest,2015,125(4):1752-1762
[3]Winer D A,Winer S,Dranse H J,et al.Immunologic impact of the intestine in metabolic disease.Journal of Clinical Investigation,2017,127(1):33-42
[4]Winer D A,Luck H,Tsai S,et al.The intestinal immune system in obesity and insulin resistance.Cell Metab,2016,23(3):413-426
[5]Cani P D,Bibiloni R,Knauf C,et al.Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.Diabetes,2008,57(6):1470-1481
[6]Luck H,Tsai S,Chung J,et al.Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.Cell Metab,2015,21(4):527-542
[7]Al-Sadi R M,Ma T Y.IL-1 causes an increase in intestinal epithelial tight junction permeability.The Journal of Immunology,2007,178(7):4641-4649
[8]Wang X,Ota N,Manzanillo P,et al.Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes.Nature,2014,514(7521):237-241
[9]Cario E,Rosenberg I M,Brandwein S L,et al.Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors.J Immunol,2000,164(2):966-972
[10]Furi I,Sipos F,Germann T M,et al.Epithelial toll-like receptor 9signaling in colorectal inflammation and cancer:Clinico-pathogenic aspects.World J Gastroenterol,2013,19(26):4119-4126
[11]Peterson L W,Artis D.Intestinal epithelial cells:Regulators of barrier function and immune homeostasis.Nat Rev Immunol,2014,14(3):141-153
[12]Pendyala S,Neff L M,Suarez-Farinas M,et al.Diet-induced weight loss reduces colorectal inflammation:implications for colorectal carcinogenesis.Am J Clin Nutr,2011,93(2):234-242
[13]Ding S,Chi M M,Scull B P,et al.High-fat diet:Bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.Plos One,2010,5(8):e12191
[14]Johnson A M,Costanzo A,Gareau M G,et al.High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability.PLo S One,2015,10(4):e122195
[15]Helen,Tsai,Sue,et al.Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.Agents,2015,21(4):527-542
[16]Monteiro-Sepulveda M,Touch S,Mendes-SáC,et al.Jejunal T cell inflammation in human obesity correlates with decreased enterocyte insulin signaling.Cell Metabolism,2015,22(1):113-124
[17]Neuman H,Debelius J W,Knight R,et al.Microbial endocrinology:The interplay between the microbiota and the endocrine system.FEMS Microbiology Reviews,2015,39(4):509-521
[18]Hall J A,Bouladoux N,Sun C M,et al.Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses.Immunity,2008,29(4):637-649
[19]Ries M,Schuster P,Thomann S,et al.Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation.J Leukoc Biol,2013,94(1):123-135
[20]Bouladoux N,Hall J A,Grainger J R,et al.Regulatory role of suppressive motifs from commensal DNA.Mucosal Immunol,2012,5(6):623-634
[21]Elce A,Amato F,Zarrilli F,et al.Butyrate modulating effects on proinflammatory pathways in human intestinal epithelial cells.Benef Microbes,2017,8(5):841-847
[22]Davis-Richardson A G,Triplett E W.A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes.Diabetologia,2015,58(7):1386-1393
[23]Honda K,Littman D R.The microbiome in infectious disease and Inflammation.Annual Review of Immunology,2012,30(1):759-795
[24]邵加庆.代谢性疾病防控的新大陆——肠道菌群.医学研究生报,2016,29(1):16-20
[25]Zhao L,Cen F,Tian F,et al.Combination treatment with quercetin and resveratrol attenuates high fat diet-induced obesity and associated inflammation in rats via the AMPKalpha1/SIRT1signaling pathway.Exp Ther Med,2017,14(6):5942-5948
[26]Bai J,Zhu Y,Dong Y.Response of gut microbiota and inflammatory status to bitter melon(Momordica charantia L.)in high fat diet induced obese rats. J Ethnopharmacol,2016,194:717-726
[27]Vazquez-Prieto M A,Bettaieb A,Haj F G,et al.(-)-Epicatechin prevents TNFalpha-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1adipocytes.Arch Biochem Biophys,2012,527(2):113-118
[28]Xu J H,Liu X Z,Pan W,et al.Berberine protects against dietinduced obesity through regulating metabolic endotoxemia and gut hormone levels.Mol Med Rep,2017,15(5):2765-2787
[29]Ye L,Liang S,Guo C,et al.Inhibition of M1 macrophage activation in adipose tissue by berberine improves insulin resistance.Life Sci,2016,166:82-91
[30]Wei Y,Gao J,Qin L,et al.TanshinoneⅠalleviates insulin resistance in type 2 diabetes mellitus rats through IRS-1 pathway.Biomed Pharmacother,2017,93:352-358
[31]Lou T,Zhang Z,Xi Z,et al.Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes.Inflammation,2011,34(6):659-667
[32]王超,张会欣,邢邯英,等.氧化苦参碱抑制p38MAPK通路减轻高脂喂养胰岛素抵抗小鼠氧化应激.中国中药杂志,2016,41(15):2872-2876
[33]Yang S J,Choi J M,Park S E,et al.Preventive effects of bitter melon(Momordica charantia)against insulin resistance and diabetes are associated with the inhibition of NF-kappa B and JNK pathways in high-fat-fed OLETF rats.J Nutr Biochem,2015,26(3):234-240
[34]Yang X,Li L,Fang K,et al.Wu-Mei-Wan reduces insulin resistance via inhibition of NLRP3 inflammasome activation in HepG2 cells.Evid Based Complement Alternat Med,2017,2017:7283241
[35]Jiang C,Yao N,Wang Q,et al.Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice.J Ethnopharmacol,2014,153(2):344-351
[36]侯丽琼,赵铁耘,张伊祎.黄连素对肥胖胰岛素抵抗大鼠骨骼肌胰岛素抵抗的干预研究.四川大学学报(医学版),2015,46(6):827-831
[37]Chang W,Chen L,Hatch G M.Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes.Biochim Biophys Acta,2016,1861(4):352-362
[38]Zhao L,Zhang Q,Ma W,et al.A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota.Food Funct,2017,8(12):4644-4656
[39]Wang J H,Kim B S,Han K,et al.Ephedra-Treated Donor-Derived Gut Microbiota Transplantation Ameliorates High Fat Diet-Induced Obesity in Rats.Int J Environ Res Public Health,2017,14(6):555
[40]Wang W,Zhao J,Gui W,et al.Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with nonalcoholic fatty liver disease.Br J Pharmacol,2018,175(3):469-484
[41]章常华,马广强,邓永兵,等.葛根芩连汤对KK-Ay糖尿病小鼠血浆中LPS、TNF-α、IL-6及肠道菌群的影响.中草药,2017,48(8):1611-1616