丹参酮类成分治疗心脑血管疾病药理活性研究进展
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摘要
丹参为唇形科植物丹参的干燥根和根茎,其化学成分根据极性差异可分为水溶性丹酚酸类成分和脂溶性丹参酮类成分。现代药理学研究表明,丹参酮类成分具有抗心肌缺血、抗动脉粥样硬化、抗凋亡、抗炎、抗氧化、脑保护等多种药理活性,在心脑血管疾病方面有较广泛的应用。针对丹参酮类成分治疗心脑血管疾病的药理活性和相关作用机制进行较为系统的综述,以期为丹参酮类成分的临床研究以及进一步开发利用提供科学依据。
引文
[1]国家药典委员会.中华人民共和国药典[M].一部.北京:中国医药科技出版社,2015:398.
[2]HAO H,WANG G,CHEN N,etal.Identification of a novel intestinal first pass metabolic pathway:NQO1mediated quinone reduction and subsequent glucuronidation[J].Curr Drug Metab,2007,8(8):137-149.
[3]CHENG TO.Danshen:apopular Chinese cardiac herbal drug[J].J Am Coll Cardiol,2006,47(7):1498.
[4]WANG BQ.Salvia miltiorrhiza:Chemical and pharmacological review of a medicinal plant[J].J Med Plant Res,2010,4(25):2813-2820.
[5]韩迪.丹参酮IIA对大鼠缺血再灌注心肌细胞凋亡的影响研究[J].现代预防医学,2011,38(13):2572-2574.
[6]YONG CJ,KIM CW,KIM YM,et al.Cryptotanshinone,a lipophilic compound of Salvia miltiorrriza root,inhibits TNF-α-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo[J].Eur J Pharmacol,2009,614(1-3):91-97.
[7]杜秋明,王存选.丹参酮IIA磺酸钠对心肌缺血再灌注性心律失常的保护作用[J].中国老年学杂志,2011(4):349-351.
[8]LUSIS A J.Atherosclerosis[J].Nature,2000,407(6801):233-241.
[9]TANG F,WU X,WANG T,et al.Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress[J].VasculPharmacol,2007,46(6):427-438.
[10]FANG ZY,LIN R,YUAN BX,et al.Tanshinone IIA downregulates the CD40expression and decreases MMP-2activity on atherosclerosis induced by high fatty diet in rabbit[J].JEthnopharmacol,2008,115(2):217-222.
[11]HUANG KJ,WANG H,XIE W Z,et al.Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging[J].Spectrochim Acta A Mol Biomol Spectrosc,2007(68):1180-1186.
[12]李永胜,王进,王照华,等.丹参酮IIA对主动脉血管内皮细胞功能损伤的保护机制[J].中国急救医学,2007(27):720-723.
[13]LAM F F,YEUNG J H,CHAN K M,et al.Dihydrotanshinone,a lipophilic component of Salvia miltiorrhiza(danshen),relaxes rat coronary artery by inhibition of calcium channels[J].Journal of Ethnopharmacology,2008,119(2):318-321.
[14]陈海明,叶攀.丹参酮IIA对血管内皮细胞氧化应激损伤的保护作用[J].中药材,2008,31(4):569-572.
[15]YANG R,LIU A,MA X,et al.Sodiumtanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation[J].JCardiovasc Pharmacol,2008,51(4):396-401.
[16]FU JJ,HUANG H Q,LIU JJ,et al.Tanshinone IIA protects cardiac myocytes against oxidative stresstriggered damage and apoptosis[J].Eur J Pharmacol,2007(568)213-221.
[17]LIN R,WANG W R,LIU J T,et al.Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism[J].Journal of Ethnopharmacology,2006,108(2):217-222.
[18]ZHANG HS,WANG SQ.Nrf2is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells[J].Biochem Pharmacol,2007(73):1358-1366.
[19]陶军,王舟琪,刘桥义,等.丹参酮防治心肌再灌注损伤的实验研究[J].中华麻醉学杂志,1996(5):202-204.
[20]JEON SJ,SON KH,KIM YS,et al.Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7cells by tanshinones from the roots of Salvia miltiorrhiza Bunge[J].Arch Pharm Res,2008(31):758-763.
[21]郭伟强,曹婷婷,徐雯婧,等.丹参酮IIA对细胞因子IL-6和IL-10的影响[J].生物技术,2008,18(6):30-32.
[22]张发艳,华声瑜,范英昌.丹酚酸B及丹参酮IIA对家兔动脉粥样硬化IL-8及VCAM-1的影响[J].山东中医药大学学报,2006,30(2):152-154.
[23]JIN DZ,YIN LL,JI XQ,etal.Cryptotanshinone inhibits cyclooxygenase-2enzyme activity but not its expression[J].Eur J Pharmacol,2006,549(1-3):166-172.
[24]韶晖,陈晓蓉,侯冠峰,等.丹参酮IIA磺酸钠对脑缺血/再灌注模型大鼠脑梗死及神经功能评分影的实验研究[J].中国中西医结合急救杂志,2012(5):287-289.
[25]魏敏,闫志强,董明清,等.丹参酮IIA预防慢性缺氧大鼠认知功能障碍的电生理机制[J].现代生物医学进展,2012,12(11):2057-2060.
[26]何治,游艳,姚岚,等.丹参酮IIA对局灶性脑缺血大鼠COX-2、PGI2以及TXA2含量的影响[J].江苏医药,2012,33(5):506-508.
[27]DONG K,XU W,YANG J,et al.Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice[J].Phytother Res,2008,23(5):608-613.
[28]TANG C,XUE H,BAI C,et al.The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats[J].Phytomedicine,2010,17(14):1145-1149.
[29]熊建华,周曙华,林玉仙.丹参酮IIA注射液治疗急性脑梗死的Meta分析[J].中国药师,2011,14(10):1481-1483.
[30]吴江,井贵平.丹参酮IIA磺酸钠对脑梗死血液指标的影响及疗效评价[J].中国医学创新,2011,20(20):19-21.
[2]HAO H,WANG G,CHEN N,etal.Identification of a novel intestinal first pass metabolic pathway:NQO1mediated quinone reduction and subsequent glucuronidation[J].Curr Drug Metab,2007,8(8):137-149.
[3]CHENG TO.Danshen:apopular Chinese cardiac herbal drug[J].J Am Coll Cardiol,2006,47(7):1498.
[4]WANG BQ.Salvia miltiorrhiza:Chemical and pharmacological review of a medicinal plant[J].J Med Plant Res,2010,4(25):2813-2820.
[5]韩迪.丹参酮IIA对大鼠缺血再灌注心肌细胞凋亡的影响研究[J].现代预防医学,2011,38(13):2572-2574.
[6]YONG CJ,KIM CW,KIM YM,et al.Cryptotanshinone,a lipophilic compound of Salvia miltiorrriza root,inhibits TNF-α-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo[J].Eur J Pharmacol,2009,614(1-3):91-97.
[7]杜秋明,王存选.丹参酮IIA磺酸钠对心肌缺血再灌注性心律失常的保护作用[J].中国老年学杂志,2011(4):349-351.
[8]LUSIS A J.Atherosclerosis[J].Nature,2000,407(6801):233-241.
[9]TANG F,WU X,WANG T,et al.Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress[J].VasculPharmacol,2007,46(6):427-438.
[10]FANG ZY,LIN R,YUAN BX,et al.Tanshinone IIA downregulates the CD40expression and decreases MMP-2activity on atherosclerosis induced by high fatty diet in rabbit[J].JEthnopharmacol,2008,115(2):217-222.
[11]HUANG KJ,WANG H,XIE W Z,et al.Investigation of the effect of tanshinone IIA on nitric oxide production in human vascular endothelial cells by fluorescence imaging[J].Spectrochim Acta A Mol Biomol Spectrosc,2007(68):1180-1186.
[12]李永胜,王进,王照华,等.丹参酮IIA对主动脉血管内皮细胞功能损伤的保护机制[J].中国急救医学,2007(27):720-723.
[13]LAM F F,YEUNG J H,CHAN K M,et al.Dihydrotanshinone,a lipophilic component of Salvia miltiorrhiza(danshen),relaxes rat coronary artery by inhibition of calcium channels[J].Journal of Ethnopharmacology,2008,119(2):318-321.
[14]陈海明,叶攀.丹参酮IIA对血管内皮细胞氧化应激损伤的保护作用[J].中药材,2008,31(4):569-572.
[15]YANG R,LIU A,MA X,et al.Sodiumtanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation[J].JCardiovasc Pharmacol,2008,51(4):396-401.
[16]FU JJ,HUANG H Q,LIU JJ,et al.Tanshinone IIA protects cardiac myocytes against oxidative stresstriggered damage and apoptosis[J].Eur J Pharmacol,2007(568)213-221.
[17]LIN R,WANG W R,LIU J T,et al.Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism[J].Journal of Ethnopharmacology,2006,108(2):217-222.
[18]ZHANG HS,WANG SQ.Nrf2is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells[J].Biochem Pharmacol,2007(73):1358-1366.
[19]陶军,王舟琪,刘桥义,等.丹参酮防治心肌再灌注损伤的实验研究[J].中华麻醉学杂志,1996(5):202-204.
[20]JEON SJ,SON KH,KIM YS,et al.Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7cells by tanshinones from the roots of Salvia miltiorrhiza Bunge[J].Arch Pharm Res,2008(31):758-763.
[21]郭伟强,曹婷婷,徐雯婧,等.丹参酮IIA对细胞因子IL-6和IL-10的影响[J].生物技术,2008,18(6):30-32.
[22]张发艳,华声瑜,范英昌.丹酚酸B及丹参酮IIA对家兔动脉粥样硬化IL-8及VCAM-1的影响[J].山东中医药大学学报,2006,30(2):152-154.
[23]JIN DZ,YIN LL,JI XQ,etal.Cryptotanshinone inhibits cyclooxygenase-2enzyme activity but not its expression[J].Eur J Pharmacol,2006,549(1-3):166-172.
[24]韶晖,陈晓蓉,侯冠峰,等.丹参酮IIA磺酸钠对脑缺血/再灌注模型大鼠脑梗死及神经功能评分影的实验研究[J].中国中西医结合急救杂志,2012(5):287-289.
[25]魏敏,闫志强,董明清,等.丹参酮IIA预防慢性缺氧大鼠认知功能障碍的电生理机制[J].现代生物医学进展,2012,12(11):2057-2060.
[26]何治,游艳,姚岚,等.丹参酮IIA对局灶性脑缺血大鼠COX-2、PGI2以及TXA2含量的影响[J].江苏医药,2012,33(5):506-508.
[27]DONG K,XU W,YANG J,et al.Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice[J].Phytother Res,2008,23(5):608-613.
[28]TANG C,XUE H,BAI C,et al.The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats[J].Phytomedicine,2010,17(14):1145-1149.
[29]熊建华,周曙华,林玉仙.丹参酮IIA注射液治疗急性脑梗死的Meta分析[J].中国药师,2011,14(10):1481-1483.
[30]吴江,井贵平.丹参酮IIA磺酸钠对脑梗死血液指标的影响及疗效评价[J].中国医学创新,2011,20(20):19-21.