增生性瘢痕中成纤维细胞向肌成纤维细胞转化的影响因素研究
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摘要
肌成纤维细胞(myofibroblast,MFB)是增生性瘢痕(hypertrophic scar,HS)形成过程中重要的效应细胞,因此TGF-β_1(transforming growth factor-β_1)介导的成纤维细胞(fibroblast,FB)向MFB的转化可成为预防HS的一个重要靶点。近年来,有很多关于人瘢痕组织内FB向MFB转化的影响因素的研究,旨在通过调控这些影响因素抑制该环节的发生,从而更有针对性地预防HS形成。本文就人瘢痕组织内FB向MFB转化的影响因素研究进展综述如下。
Myofibroblast( MFB) is an important effector cell in the formation of hypertrophic scar(HS). Therefore, the transformation of fibroblast( FB) to MFB mediated by TGF-β_1( transforming growth factor-β_1) can be an important target for the prevention of HS. In recent years, there have been many studies on the influencing factors of transformation of FB to MFB in HS, aiming at preventing the formation of HS more precisely by regulating these factors. This article intends to analyze the factors that affect the conversion of FB to MFB in human HS.
Myofibroblast( MFB) is an important effector cell in the formation of hypertrophic scar(HS). Therefore, the transformation of fibroblast( FB) to MFB mediated by TGF-β_1( transforming growth factor-β_1) can be an important target for the prevention of HS. In recent years, there have been many studies on the influencing factors of transformation of FB to MFB in HS, aiming at preventing the formation of HS more precisely by regulating these factors. This article intends to analyze the factors that affect the conversion of FB to MFB in human HS.
引文
[1]李盛.不同浓度葡萄糖对体外培养小鼠成纤维细胞功能的影响[D].广州:中山大学,2009.
[2]傅士博,温从吉,王琛,等.张力刺激皮肤成纤维细胞向肌成纤维细胞分化的实验研究[J].组织工程与重建外科杂志,2014,10(3):127-130.
[3]Wong VW,Rustad KC,Akaishi S,et al.Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling[J].Nature Med,2012,18(1):148-152.
[4]章伏生,陆树良.肌成纤维细胞在皮肤瘢痕形成过程中的作用[J].中华创伤杂志,2009,25(12):1106-1109.
[5]胥广,黄东.增生性瘢痕形成机制及治疗的现况与展望[J].现代医院,2015,15(2):10-14.
[6]Wang R,Ghahary A,Shen Q,et a1.Hypertrophic scar tissues and fibmblasts produce mole transforming growth factor-betal mBNA and protein than normal skin and ceils[J].Wound Repair Regen,2000,8(2):128-137.
[7]Mingyuan X,Qianqian P,Shengquan X,et al.Hypoxia-inducible factor-1αactivates transforming growth factor-β1/Smad signaling and increases collagen deposition in dermal fibroblasts[J].Oncotarget,2018,9(3):3188-3197.
[8]Kischer CW,Shetlar MR.Microvasculature in hypertrophic scars and the effects of pressure[J].Trauma,1979,19(10):757-764.
[9]Zhao B,Guan H,Liu JQ,et al.Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway[J].Int J Molecular Med,2017,39(1):153-159.
[10]YAN Li,Julei Zhang,Qin Zhou,et al.Linagliptin inhibits high glucose-induced trans-differentiation of hypertrophic scar derived fibroblasts to myofibroblasts via IGF/AKT/mTOR signaling pathway[J].PLoS One,2018,13(7):e0200249.
[11]牟姗,张庆怡,赵涵芳.高浓度葡萄糖对人肾间质成纤维细胞增殖及PAI-1基因表达的影响[J].上海第二医科大学学报,2002,22(2):118-120.
[12]Gurtner GC,Dauskardt RH,Wong VW,et al.Improving cutaneous scar formation by controlling the mechanical environment:large animal and phase I studies[J].Ann Surg,2011,254(2):217-225.
[13]Liu B,Liu Y,Wang L,et al.The effects of pressure intervention on wound healing and scar formation in a Bama minipig model[J].Burns,2018,18:30541-30542.
[14]Lesaint M,Balaji S,Bhattacharya SS,et al.Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing andinduces angiogenesis[J].Surg Res,2014,190(1):367-377.
[15]Rolin G,Binda D,Tissot M,et al.In vitro,study of the impact of mechanical tension on the dermal fibroblast phenotype in the context of skin wound healing[J].J Biome,2014,47(14):3555-3561.
[16]Dolivo DM,Larson SA,Dominko T.Fibroblast growth factor 2 as an antifibrotic:antagonism of myofibroblast differentiation and suppression of pro-fibrotic gene expression[J].Cytokine Growth Factor Rev,2017,38:49-58.
[17]Dolivo DM,Larson SA,Dominko T.FGF2-mediated attenuation of myofibroblast activation is modulated by distinct MAPKsignaling pathways in human dermal fibroblasts[J].J Dermatol Sci,2017,88(3):339-348.
[18]Koo HY,Elbaz L,House SL,et al.Fibroblast growth factor 2decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation[J].JPathology,2018,246(1):54-66.
[19]Wei Q,Ning L,Qian C,et al.Thrombospondin-4 critically controls transforming growth factorβ1 induced hypertrophic scar formation[J].J Cellular Physiology,2018,234(1):731-739.
[20]Bi S,Chai L,Yuan X,et al.MicroRNA-98 in hibits the cell proliferation of human hypertrophic scar fibroblasts via targeting Col1A1[J].Biol Res,2017,50(1):22-30.
[21]Zhu HY,Li C,Bai WD,et al.MicroRNA-21 regulates hTERT via PTENin hy pertrophic scar fibroblasts[J].PLoS One,2014,9(5):e97114.
[22]Chen Q,Zhao T,Xie X,et al.MicroRNA-663 regulates the proliferation of fibroblasts in hypertrophic scars via transforming growth factor-β1[J].Exper Therapeutic Medicine,2018,16(2):1311-1317.
[23]Qian Zhang,Bing yu Guo,Qiang Hui.miR-137 inhibits proliferation and metastasis of hypertrophic scar fibroblasts via targeting pleiotrophin[J].Cell Physiol Biochem,2018,49:1026-1036.
[24]Liu F,Chen WW,Li Y,et al.MiR-6836-3p promotes proliferation of hypertrophic scar fibroblasts by targeting CTGF[J].European Review Medical Pharmacological Sciences,2018,22(13):4069-4074.
[25]Kodama H,Kumai Y,Nishimoto K,et al.Potential treatment for vocal fold scar with pirfenidone[J].Laryngoscope,2017,128(5):E171-E177.
[26]Medina JL,Sebastian E A,Fourcaudot AB,et al.Pirfenidone ointment modulates the burn wound bed in C57Bl/6 mice by suppressing inflammatory responses[J].Inflammation,2019,42(1):45-53.
[27]Sun Y,Zhang Y,Chi P.Pirfenidone suppresses TGF-β1-induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K/AKT signaling pathway[J].Mol Med Rep,2018,18(4):3907-3913.
[28]Song Y,Guo B,Ma S,et al.Naringin suppresses the growth and motility of hypertrophic scar fibroblasts by inhibiting the kinase activity of AKT[J].Biomedicine Pharmacotherapy,2018,105:1291-1298.
[29]Lingzhi Z,Haojie H,Deyun C,et al.Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2(NFE2L2)protein and the Smad2/3 pathway[J].Cell Physiol,2018,234(3):2606-2617.
[2]傅士博,温从吉,王琛,等.张力刺激皮肤成纤维细胞向肌成纤维细胞分化的实验研究[J].组织工程与重建外科杂志,2014,10(3):127-130.
[3]Wong VW,Rustad KC,Akaishi S,et al.Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling[J].Nature Med,2012,18(1):148-152.
[4]章伏生,陆树良.肌成纤维细胞在皮肤瘢痕形成过程中的作用[J].中华创伤杂志,2009,25(12):1106-1109.
[5]胥广,黄东.增生性瘢痕形成机制及治疗的现况与展望[J].现代医院,2015,15(2):10-14.
[6]Wang R,Ghahary A,Shen Q,et a1.Hypertrophic scar tissues and fibmblasts produce mole transforming growth factor-betal mBNA and protein than normal skin and ceils[J].Wound Repair Regen,2000,8(2):128-137.
[7]Mingyuan X,Qianqian P,Shengquan X,et al.Hypoxia-inducible factor-1αactivates transforming growth factor-β1/Smad signaling and increases collagen deposition in dermal fibroblasts[J].Oncotarget,2018,9(3):3188-3197.
[8]Kischer CW,Shetlar MR.Microvasculature in hypertrophic scars and the effects of pressure[J].Trauma,1979,19(10):757-764.
[9]Zhao B,Guan H,Liu JQ,et al.Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway[J].Int J Molecular Med,2017,39(1):153-159.
[10]YAN Li,Julei Zhang,Qin Zhou,et al.Linagliptin inhibits high glucose-induced trans-differentiation of hypertrophic scar derived fibroblasts to myofibroblasts via IGF/AKT/mTOR signaling pathway[J].PLoS One,2018,13(7):e0200249.
[11]牟姗,张庆怡,赵涵芳.高浓度葡萄糖对人肾间质成纤维细胞增殖及PAI-1基因表达的影响[J].上海第二医科大学学报,2002,22(2):118-120.
[12]Gurtner GC,Dauskardt RH,Wong VW,et al.Improving cutaneous scar formation by controlling the mechanical environment:large animal and phase I studies[J].Ann Surg,2011,254(2):217-225.
[13]Liu B,Liu Y,Wang L,et al.The effects of pressure intervention on wound healing and scar formation in a Bama minipig model[J].Burns,2018,18:30541-30542.
[14]Lesaint M,Balaji S,Bhattacharya SS,et al.Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing andinduces angiogenesis[J].Surg Res,2014,190(1):367-377.
[15]Rolin G,Binda D,Tissot M,et al.In vitro,study of the impact of mechanical tension on the dermal fibroblast phenotype in the context of skin wound healing[J].J Biome,2014,47(14):3555-3561.
[16]Dolivo DM,Larson SA,Dominko T.Fibroblast growth factor 2 as an antifibrotic:antagonism of myofibroblast differentiation and suppression of pro-fibrotic gene expression[J].Cytokine Growth Factor Rev,2017,38:49-58.
[17]Dolivo DM,Larson SA,Dominko T.FGF2-mediated attenuation of myofibroblast activation is modulated by distinct MAPKsignaling pathways in human dermal fibroblasts[J].J Dermatol Sci,2017,88(3):339-348.
[18]Koo HY,Elbaz L,House SL,et al.Fibroblast growth factor 2decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation[J].JPathology,2018,246(1):54-66.
[19]Wei Q,Ning L,Qian C,et al.Thrombospondin-4 critically controls transforming growth factorβ1 induced hypertrophic scar formation[J].J Cellular Physiology,2018,234(1):731-739.
[20]Bi S,Chai L,Yuan X,et al.MicroRNA-98 in hibits the cell proliferation of human hypertrophic scar fibroblasts via targeting Col1A1[J].Biol Res,2017,50(1):22-30.
[21]Zhu HY,Li C,Bai WD,et al.MicroRNA-21 regulates hTERT via PTENin hy pertrophic scar fibroblasts[J].PLoS One,2014,9(5):e97114.
[22]Chen Q,Zhao T,Xie X,et al.MicroRNA-663 regulates the proliferation of fibroblasts in hypertrophic scars via transforming growth factor-β1[J].Exper Therapeutic Medicine,2018,16(2):1311-1317.
[23]Qian Zhang,Bing yu Guo,Qiang Hui.miR-137 inhibits proliferation and metastasis of hypertrophic scar fibroblasts via targeting pleiotrophin[J].Cell Physiol Biochem,2018,49:1026-1036.
[24]Liu F,Chen WW,Li Y,et al.MiR-6836-3p promotes proliferation of hypertrophic scar fibroblasts by targeting CTGF[J].European Review Medical Pharmacological Sciences,2018,22(13):4069-4074.
[25]Kodama H,Kumai Y,Nishimoto K,et al.Potential treatment for vocal fold scar with pirfenidone[J].Laryngoscope,2017,128(5):E171-E177.
[26]Medina JL,Sebastian E A,Fourcaudot AB,et al.Pirfenidone ointment modulates the burn wound bed in C57Bl/6 mice by suppressing inflammatory responses[J].Inflammation,2019,42(1):45-53.
[27]Sun Y,Zhang Y,Chi P.Pirfenidone suppresses TGF-β1-induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K/AKT signaling pathway[J].Mol Med Rep,2018,18(4):3907-3913.
[28]Song Y,Guo B,Ma S,et al.Naringin suppresses the growth and motility of hypertrophic scar fibroblasts by inhibiting the kinase activity of AKT[J].Biomedicine Pharmacotherapy,2018,105:1291-1298.
[29]Lingzhi Z,Haojie H,Deyun C,et al.Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2(NFE2L2)protein and the Smad2/3 pathway[J].Cell Physiol,2018,234(3):2606-2617.