着床汤对冻融胚胎移植周期干预效应的临床观察
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摘要
目的:研究着床汤对行冻融胚胎移植(FET)患者治疗的可行性和有效性。方法:回顾性分析2017年2月至2018年2月于郑州大学第一附属医院生殖医学中心行FET的1 474例患者。着床汤配合西药组(干预组,737例)和西药组(对照组,737例)。对照组采用常规的FET方案;干预组于移植第1天起同时加服着床汤,每日1剂,连服12d。观察两组患者总临床妊娠率、高龄临床妊娠率、卵裂期胚胎临床妊娠率、囊胚临床妊娠率、多周期临床妊娠率、异位妊娠率、流产率。结果:与对照组比较,干预组患者高龄临床妊娠率、多周期临床妊娠率显著升高(P<0.05),总临床妊娠率、卵裂期胚胎临床妊娠率、囊胚临床妊娠率、异位妊娠率、流产率差异无统计学意义。结论:在FET助孕周期,应用着床汤可纳胎养胎,促进胚胎着床,改善高龄及多周期患者的临床妊娠率,具有临床指导意义。
Objective: To study the feasibility and effectiveness of Implantation Decoction in the treatment of patients undergoing frozen-thawed embryo transfer(FET). Methods: A total of 1 474 cases of FET were retrospectively analyzed from February 2017 to February 2018 in the Reproductive Center of The First Affiliated Hospital of Zhengzhou University. Implantation Decoction was combined with western medicine group(intervention group, 737 cases) and western medicine group(control group, 737 cases). In the control group, conventional protocol for frozen-thawed embryo transfer was used. Intervention group was given one dose of Implantation Decoction every day for 12 days after transplantation. The total clinical pregnancy rate, clinical pregnancy rate at old age, clinical pregnancy rate at cleavage embryo, clinical pregnancy rate at blastocyst, multicycle clinical pregnancy rate, ectopic pregnancy rate and abortion rate were observed. Results: Compared with control group, the intervention group patients clinical pregnancy rate in the elderly and multi-cycle clinical pregnancy rate increased significantly(P<0.05), the total clinical pregnancy rate, cleavage stage embryos clinical pregnancy rate, blastocyst clinical pregnancy rate, rate of ectopic pregnancy, abortion rate was no statistical difference. Conclusion: The application of implantation decoction for frozenthawed embryo transfer cycle can promote implantation of embryos and improve the clinical pregnancy rate of elderly and patients with multiple cycles.
Objective: To study the feasibility and effectiveness of Implantation Decoction in the treatment of patients undergoing frozen-thawed embryo transfer(FET). Methods: A total of 1 474 cases of FET were retrospectively analyzed from February 2017 to February 2018 in the Reproductive Center of The First Affiliated Hospital of Zhengzhou University. Implantation Decoction was combined with western medicine group(intervention group, 737 cases) and western medicine group(control group, 737 cases). In the control group, conventional protocol for frozen-thawed embryo transfer was used. Intervention group was given one dose of Implantation Decoction every day for 12 days after transplantation. The total clinical pregnancy rate, clinical pregnancy rate at old age, clinical pregnancy rate at cleavage embryo, clinical pregnancy rate at blastocyst, multicycle clinical pregnancy rate, ectopic pregnancy rate and abortion rate were observed. Results: Compared with control group, the intervention group patients clinical pregnancy rate in the elderly and multi-cycle clinical pregnancy rate increased significantly(P<0.05), the total clinical pregnancy rate, cleavage stage embryos clinical pregnancy rate, blastocyst clinical pregnancy rate, rate of ectopic pregnancy, abortion rate was no statistical difference. Conclusion: The application of implantation decoction for frozenthawed embryo transfer cycle can promote implantation of embryos and improve the clinical pregnancy rate of elderly and patients with multiple cycles.
引文
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[2]徐丽珍.促排卵过程中卵巢高反应对子宫内膜容受性的影响及其相关机制.济南:山东大学,2017
[3]王肖,尤昭玲.中医药在辅助生殖技术中的应用.时珍国医国药,2015,26(7):1728-1730
[4]金保方.中医药在现代生殖医学中的地位.生殖医学杂志,2013,22(12):899-904
[5]王肖.护卵汤对体外受精-胚胎移植长方案干预效应的临床研究.长沙:湖南中医药大学,2015
[6]申奏秦旋,申可佳,熊桀,等.护卵汤对多周期促排卵小鼠子宫内膜ER/PR蛋白表达的影响.湖南中医药大学学报,2017,37(5):473-476
[7]乐杰.妇产科学.7版.北京:人民卫生出版社,2008:351-355
[8]陈佩玲.《傅青主女科·种子》治脾思想浅析.中医临床研究,2013,22(22):50-51
[9]冯晓芬,殷红光,吴华,等.肾主生殖的理论渊源及肾精不足的特点.黑龙江医学,2013,37(1):17-19
[10]王肖.中医药“四期三法”辅治体外受精-胚胎移植的辨治思路.中华中医药杂志,2017,31(3):156-158