MSCT定量研究技术与肺癌患者预后的关系分析
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摘要
目的研究多层螺旋CT(MSCT)定量研究技术参数在肺癌患者中的表现及其与预后的关系。方法回顾性分析2012年1月～2018年10月我院收治80例肺癌患者的临床资料和随访资料,对其MSCT检查结果和肺功能仪检查结果进行整理和比较,纳入同期于我院行体检的健康人50例为正常对照组,将其检查结果与肺癌患者进行比较和相关性分析,对80例肺癌患者进行随访调查,根据其预后情况将其分为预后良好组和预后不佳组,对比两组患者MSCT参数。结果肺癌患者vex、vin-vex、vex/vin、 MLDex、MLDexMLDin、单位体积密度与正常人比较,差异有统计学意义(P <0.05);肺癌患者MSCT参数与大部分肺功能仪检查参数均具有良好相关性,Vin与TLC、Vex与RV、vin-vex与FVC、vin/vex与RV/TLC相关性最佳,均呈正相关(r=0.75、0.84、0.79、0.91,P <0.01),EVin与FEV1、EVex与FEV1相关性较佳,均呈负相关(r=-0.56、-0.78,P <0.01);预后良好组患者Vin、vex、vin-vex、vex/vin与预后不良组患者比较,差异均有统计学意义(P <0.05)。结论 MSCT定量检查肺癌患者肺功能与肺功能试验相较更为准确、客观,其定量参数与肺功能存在良好相关性,可提示肺癌患者预后。
Objective To study the performance of multi-slice spiral CT(MSCT) quantitative research technique parameters in patients with lung cancer and its relationship with prognosis. Methods The clinical data and followup data of 80 patients with lung cancer who were admitted to our hospital from January 2012 to October 2018 were retrospectively analyzed. The results of MSCT examination and pulmonary function instrument were collated and compared.50 healthy people who underwent physical examinations in our hospital during the same period were selected as the normal control group. Results of examination of those healthy people were given comparison and correlation analysis with those of patients with lung cancer. 80 patients with lung cancer were followed up for investigation. They were divided into good prognosis group and poor prognosis group according to the prognosis, and the MSCT parameters were compared between the two groups. Results There were statistically significant differences in the vex, vin-vex, vex/vin, MLDex, MLDex-MLD and unit volume density between patients with lung cancer and normal people(P < 0.05). The MSCT parameters of patients with lung cancer had good correlation with most parameters of pulmonary function instrument. Vin and TLC, Vex and RV, vinvex and FVC, vin/vex and RV/TLC had the best correlation and they were positively correlated(correlation coefficients were0.75, 0.84, 0.79, 0.91, P < 0.01). And EVin and FEV1, EVex and FEV1 had good correlation, and they were negatively correlated(correlation coefficients were-0.56,-0.78, P < 0.01). There were statistically significant differences in Vin, vex,vin-vex and vex/vin between good prognosis group and poor prognosis group(P < 0.05). Conclusion MSCT quantitative examination of lung function in patients with lung cancer is more accurate and objective than pulmonary function instrument.And its quantitative parameters have good correlation with lung function, which can indicate the prognosis of patients with lung cancer.
Objective To study the performance of multi-slice spiral CT(MSCT) quantitative research technique parameters in patients with lung cancer and its relationship with prognosis. Methods The clinical data and followup data of 80 patients with lung cancer who were admitted to our hospital from January 2012 to October 2018 were retrospectively analyzed. The results of MSCT examination and pulmonary function instrument were collated and compared.50 healthy people who underwent physical examinations in our hospital during the same period were selected as the normal control group. Results of examination of those healthy people were given comparison and correlation analysis with those of patients with lung cancer. 80 patients with lung cancer were followed up for investigation. They were divided into good prognosis group and poor prognosis group according to the prognosis, and the MSCT parameters were compared between the two groups. Results There were statistically significant differences in the vex, vin-vex, vex/vin, MLDex, MLDex-MLD and unit volume density between patients with lung cancer and normal people(P < 0.05). The MSCT parameters of patients with lung cancer had good correlation with most parameters of pulmonary function instrument. Vin and TLC, Vex and RV, vinvex and FVC, vin/vex and RV/TLC had the best correlation and they were positively correlated(correlation coefficients were0.75, 0.84, 0.79, 0.91, P < 0.01). And EVin and FEV1, EVex and FEV1 had good correlation, and they were negatively correlated(correlation coefficients were-0.56,-0.78, P < 0.01). There were statistically significant differences in Vin, vex,vin-vex and vex/vin between good prognosis group and poor prognosis group(P < 0.05). Conclusion MSCT quantitative examination of lung function in patients with lung cancer is more accurate and objective than pulmonary function instrument.And its quantitative parameters have good correlation with lung function, which can indicate the prognosis of patients with lung cancer.
引文
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[11]黄鼎祥.多层螺旋CT肺容积测定与肺功能检查对肺气肿诊断价值的比较[J].临床肺科杂志,2015,20(4):692-694.
[12]郭玉峰,牛朋影,哈若水.低剂量MSCT双相扫描肺容积测量在COPD诊断中的价值及与PFT相关性研究[J].宁夏医学杂志,2015,37(6):544-546.
[13]朱健,孙梦月,高秀江,等.多层螺旋CT联合肺功能对特发性肺纤维化预后价值研究[J].中国煤炭工业医学杂志,2016,19(5):695-698.
[14]欧阳志成,许萍.慢性阻塞性肺疾病多层螺旋CT表现与肺功能相关性的研究进展[J].实用临床医学,2017,18(8):101-104.
[15]管宇,范丽,夏艺,等.慢性阻塞性肺疾病患者小气道重塑及肺叶水平肺气肿的CT定量分析及其与肺功能的相关性研究[J].中国医学影像技术,2015,31(2):181-185.
[2]马云帆,范梦颖,陈克能.肺鳞癌与肺腺癌的免疫组化指标的诊断及预后意义[J].中国肺癌杂志,2014,17(6):506-510.
[3]魏晓玲.四种肿瘤标记物联合检测在肺癌诊断中的价值[J].河北医药,2017,39(6):854-856.
[4]刘亚斌,周成香,白琛,等.慢性阻塞性肺疾病MSCT肺测量与PFT检查的对比研究[J].成都医学院学报,2017,12(4):481-483.
[5]陆舜,虞永峰,纪文翔.2015年肺癌诊疗指南:共识和争议[J].解放军医学杂志,2016,41(1):1-6.
[6]路明,姚婉贞.慢性阻塞性肺疾病防治全球倡议(2015年更新版)解读[J].中华医学杂志,2015,95(22):1715-1718.
[7]中华医学会放射学分会心胸学组.低剂量螺旋CT肺癌筛查专家共识[J].中华放射学杂志,2015,49(5):328-335.
[8]孙洪福,王中堂,周涛,等.SPECT/CT肺灌注显像评价非小细胞肺癌患者肺功能的价值及相关因素研究[J].中华核医学与分子影像杂志,2016,36(4):322-325.
[9]王之悦,祝因苏,陈雪松,等.多层螺旋CT肺小血管与肺截面积比值评价慢性阻塞性肺疾病严重程度的作用[J].中华放射学杂志,2016,50(2):86-90.
[10]顾亚律,陆信,凌锋,等.MSCT对肺减容术肺形态及功能预测的临床应用研究[J].中国CT和MRI杂志,2015,13(4):27-29.
[11]黄鼎祥.多层螺旋CT肺容积测定与肺功能检查对肺气肿诊断价值的比较[J].临床肺科杂志,2015,20(4):692-694.
[12]郭玉峰,牛朋影,哈若水.低剂量MSCT双相扫描肺容积测量在COPD诊断中的价值及与PFT相关性研究[J].宁夏医学杂志,2015,37(6):544-546.
[13]朱健,孙梦月,高秀江,等.多层螺旋CT联合肺功能对特发性肺纤维化预后价值研究[J].中国煤炭工业医学杂志,2016,19(5):695-698.
[14]欧阳志成,许萍.慢性阻塞性肺疾病多层螺旋CT表现与肺功能相关性的研究进展[J].实用临床医学,2017,18(8):101-104.
[15]管宇,范丽,夏艺,等.慢性阻塞性肺疾病患者小气道重塑及肺叶水平肺气肿的CT定量分析及其与肺功能的相关性研究[J].中国医学影像技术,2015,31(2):181-185.