重组牛碱性成纤维细胞生长因子辅助治疗儿童口腔溃疡疗效分析
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摘要
目的:探讨重组牛碱性成纤维细胞生长因子辅助治疗儿童口腔溃疡的效果及对白细胞介素(IL)-6、IL-8水平的影响。方法:选取2015年5月至2017年7月我院收治的口腔溃疡患儿92例,根据随机数字表法分为两组,对照组46例使用常规药物治疗,研究组46例使用重组牛碱性成纤维细胞生长因子辅助治疗,比较两组患儿临床治疗效果以及对IL-6、IL-8水平的影响。结果:研究组临床总有效率为97. 8%,显著高于对照组的80. 4%(P<0. 05);研究组疼痛缓解时间、创面愈合时间以及完全进食时间分别为(3. 8±1. 2) d、(4. 1±1. 2) d和(3. 9±0. 9) d,均明显优于对照组的(5. 7±1. 9) d、(5. 9±2. 2) d和(4. 5±1. 4) d(均P<0. 05)。治疗后研究组IL-6、IL-8水平分别为(10. 1±2. 4) ng/L和(0. 5±0. 1) ng/L,均明显低于对照组的(14. 6±3. 4) ng/L和(0. 6±0. 3) ng/L(均P<0. 05)。结论:重组牛碱性成纤维细胞生长因子辅助治疗儿童口腔溃疡效果良好,值得临床推广。
Objective: To investigate the efficacy of recombinant bovine basic fibroblast growth factor( rb-bFGF) in adjuvant treatment of children with oral ulcer and its effects on levels of interleukin( IL)-6 and IL-8. Methods: A total of 92 children with oral ulcer in our hospital from May 2015 to Jul. 2017 were extracted to be divided into the control group and the research group via the random number table. The control group( n = 46) was treated with conventional drug therapy,while the research group( n = 46)received rb-bFGF. The clinical efficacy and the effects on levels of IL-6 and IL-8 in both groups were compared. Results: The clinical effective rate of the research group was 97. 8%,significantly higher than that of the control group,with statistically significant difference( P< 0. 05). The relief time of pain,healing time of wound and complete feeding time of the research group were( 3. 8 ±1. 2) d,( 4. 1± 1. 2) d and( 3. 9± 0. 9) d,respectively,significantly better than those of the control group( 5. 7± 1. 9) d,( 5. 9±2. 2) d and( 4. 5± 1. 4) d,with statistically significant difference( P< 0. 05). The levels of IL-6 and IL-8 in the research group were( 10. 1±2. 4) ng/L and( 0. 51±0. 1) ng/L,respectively,significantly lower than those of the control group( 14. 6±3. 4) ng/L and( 0. 6±0. 3) ng/L( P<0. 05). Conclusion: The efficacy of rb-bFGF in adjuvant treatment of children with oral ulcer is significant,which is worthy of clinical promotion.
Objective: To investigate the efficacy of recombinant bovine basic fibroblast growth factor( rb-bFGF) in adjuvant treatment of children with oral ulcer and its effects on levels of interleukin( IL)-6 and IL-8. Methods: A total of 92 children with oral ulcer in our hospital from May 2015 to Jul. 2017 were extracted to be divided into the control group and the research group via the random number table. The control group( n = 46) was treated with conventional drug therapy,while the research group( n = 46)received rb-bFGF. The clinical efficacy and the effects on levels of IL-6 and IL-8 in both groups were compared. Results: The clinical effective rate of the research group was 97. 8%,significantly higher than that of the control group,with statistically significant difference( P< 0. 05). The relief time of pain,healing time of wound and complete feeding time of the research group were( 3. 8 ±1. 2) d,( 4. 1± 1. 2) d and( 3. 9± 0. 9) d,respectively,significantly better than those of the control group( 5. 7± 1. 9) d,( 5. 9±2. 2) d and( 4. 5± 1. 4) d,with statistically significant difference( P< 0. 05). The levels of IL-6 and IL-8 in the research group were( 10. 1±2. 4) ng/L and( 0. 51±0. 1) ng/L,respectively,significantly lower than those of the control group( 14. 6±3. 4) ng/L and( 0. 6±0. 3) ng/L( P<0. 05). Conclusion: The efficacy of rb-bFGF in adjuvant treatment of children with oral ulcer is significant,which is worthy of clinical promotion.
引文
[1]范美君,王金龄,马锴,等.双黄连口服液联合康复新液治疗儿童口腔溃疡57例临床研究[J].儿科药学杂志,2018,24(1):31-33.
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[11]张敬,沙晶晶,龚娟.转化生长因子-β1和白细胞介素-10单核苷酸多态性与复发性口腔溃疡易感性的研究[J].华西口腔医学杂志,2016,34(1):27-31.
[12]钱进,钟良军.西地碘含片联合康复新液对复发性口腔溃疡患儿血浆中细胞因子的影响[J].中国临床药理学杂志,2016,32(17):1539-1542.
[13]郑琦,麻海鹏,屠方琴,等.黄芪注射液联合阿糖腺苷对小儿手足口病患儿血清中炎症因子水平等相关指标影响研究[J].中华中医药学刊,2017(4):974-976.
[14]杜小蓉,蒋仕祥.对口腔溃疡患儿使用维生素E联合利多卡因进行治疗的效果分析[J].当代医药论丛,2018,16(5):208-209.
[15]TIPTON D A,CHRISTIAN J,BLUMER A. Effects of cranberry components on IL-1β-stimulated production of IL-6,IL-8 and VEGF by human TMJ synovial fibroblasts[J]. Archives of oral biology,2016,68(4):88-96.
[16]HANUDEL M R,WESSELINGPERRY K,GALES B,et al.Effects of acute kidney injury and chronic hypoxemia on fibroblast growth factor 23 levels in pediatric cardiac surgery patients[J]. Pediatric nephrology,2016,31(4):661-669.
[17]马启海.血必净注射液联合重组牛碱性成纤维细胞生长因子凝胶治疗深度烧伤残余创面的临床研究[J].现代药物与临床,2017,32(12):2469-2472.
[18]罗政,陈鹏,谷玉平,等. IL-6、IL-8、Lp-PLA2对H型高血压合并缺血性脑卒中临床意义探讨[J].中风与神经疾病杂志,2016,33(7):613-615.
[2]邓雪莲,劳均平,郭庆平,等. RAU病变期外周血细胞免疫功能检测及临床意义[J].临床口腔医学杂志,2005,21(4):244-245.
[3]孙旋,杜秀平,韩正祥.重组人粒细胞巨噬细胞集落刺激因子联合重组牛碱性成纤维细胞生长因子治疗化疗性口腔溃疡的临床观察[J].肿瘤研究与临床,2015,27(4):263-265.
[4]HUANG G,SUN T,ZHANG L,et al. Combined application of alginate dressing and human granulocyte-macrophage colony stimulating factor promotes healing in refractory chronic skin ulcers[J]. Experimental&therapeutic medicine,2014,7(6):1772-1776.
[5]张举之.口腔内科学[M].第3版.北京:人民卫生出版社,1999:358.
[6]王诗源,刘巍,李大可,等.清热化浊降酸方对急性痛风性关节炎患儿血清IL-1β、IL-6、IL-8水平的影响[J].山东医药,2018(2):93-95.
[7]范筱,刘洁羽.复方甘草酸苷联合柳氮磺吡啶对溃疡性结肠炎患儿血清IL-6、IL-8及TNF-α水平的影响[J].中国地方病防治杂志,2017,32(2):137-138.
[8]庄贤栩,裴仁治,陆滢,等.复方皂矾丸联合重组人粒细胞刺激因子注射液对白血病化疗后白细胞减少患儿血清IL-6、IL-8及G-CSF水平影响研究[J].中华中医药学刊,2017(5):1275-1277.
[9]GALIMOV A,MERRY T L,LUCA E,et al. MicroRNA-29a in adult muscle stem cells controls skeletal muscle regeneration during injury and exercise downstream of fibroblast growth factor-2[J]. Stem cells,2016,34(3):768-780.
[10] CHIEN S Y,HUANG C Y,TSAI C H,et al. Interleukin-1βinduces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes[J]. Clinical science,2016,130(9):667-681.
[11]张敬,沙晶晶,龚娟.转化生长因子-β1和白细胞介素-10单核苷酸多态性与复发性口腔溃疡易感性的研究[J].华西口腔医学杂志,2016,34(1):27-31.
[12]钱进,钟良军.西地碘含片联合康复新液对复发性口腔溃疡患儿血浆中细胞因子的影响[J].中国临床药理学杂志,2016,32(17):1539-1542.
[13]郑琦,麻海鹏,屠方琴,等.黄芪注射液联合阿糖腺苷对小儿手足口病患儿血清中炎症因子水平等相关指标影响研究[J].中华中医药学刊,2017(4):974-976.
[14]杜小蓉,蒋仕祥.对口腔溃疡患儿使用维生素E联合利多卡因进行治疗的效果分析[J].当代医药论丛,2018,16(5):208-209.
[15]TIPTON D A,CHRISTIAN J,BLUMER A. Effects of cranberry components on IL-1β-stimulated production of IL-6,IL-8 and VEGF by human TMJ synovial fibroblasts[J]. Archives of oral biology,2016,68(4):88-96.
[16]HANUDEL M R,WESSELINGPERRY K,GALES B,et al.Effects of acute kidney injury and chronic hypoxemia on fibroblast growth factor 23 levels in pediatric cardiac surgery patients[J]. Pediatric nephrology,2016,31(4):661-669.
[17]马启海.血必净注射液联合重组牛碱性成纤维细胞生长因子凝胶治疗深度烧伤残余创面的临床研究[J].现代药物与临床,2017,32(12):2469-2472.
[18]罗政,陈鹏,谷玉平,等. IL-6、IL-8、Lp-PLA2对H型高血压合并缺血性脑卒中临床意义探讨[J].中风与神经疾病杂志,2016,33(7):613-615.