丹参酮提取物物理化学质量属性相关性分析
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摘要
目的:探寻丹参酮提取物化学成分的含量与物理性质之间的相关性。方法:HPLC测定50批丹参酮提取物中隐丹参酮、丹参酮IIA的含量,经典方法测定物理性质,将成分含量与物理性质进行相关性分析。结果:两变量组组内的隐丹参酮与丹参酮IIA含量,D10、D50、D90之间,松装密度与振实密度,豪斯纳比率与压缩度指数均具有较强的相关性,休止角与均齐度、豪斯纳比率、压缩度指数具有一定的相关性,但相关性不强。两变量组的原始变量组间相关性系数最大不超过0.400,相关性不强。经过典型相关分析,3对典型变量的相关性显著,相关系数分别为0.851,0.674,0.565。结论:对于丹参酮提取物的化学、物理质量属性,原始变量组内具有较好的相关性,但组间相关性较差。相比原始变量,典型变量呈现出了较好的组间相关性,表明丹参酮提取物的物理化学属性之间具有一定的相关性。
This study was aimed to find out the correlation between chemical component contents and physical properties of tanshinone extract powders. The contents of cryptotanshinone and tanshinone IIA from 50 batches of tanshinone extract powders were determined by HPLC. And the physical properties were determined by classical methods.The correlation analysis between component contents and physical properties were also investigated. The results showed that two sets of variables had good intraclass correlation, especially for the contents of cryptotanshinone and tanshinone IIA, among D10, D50, D90, there were relatively strong correlation between the bulk density and tapped density, between the Hausner ratio and compressibility index. The angle of repose had a certain correlation with the uniformity, Hausner ratio and compressibility index, but with no strong correlation. The correlation coefficient between two sets was below 0.400, suggesting there was a not so good inter-group correlation. After the canonical correlation analysis, three pairs of canonical variables had significant correlations with correlation coefficients being0.851, 0.674 and 0.565, respectively. It was concluded that there was a good intraclass correlation for each of physical and/or chemical quality set, but the correlation between the two sets was bad. Canonical variables performed better inter-group correlation compared with original variables, indicating there was a certain correlation between chemical and physical quality attributes of tanshinone extract powders.
This study was aimed to find out the correlation between chemical component contents and physical properties of tanshinone extract powders. The contents of cryptotanshinone and tanshinone IIA from 50 batches of tanshinone extract powders were determined by HPLC. And the physical properties were determined by classical methods.The correlation analysis between component contents and physical properties were also investigated. The results showed that two sets of variables had good intraclass correlation, especially for the contents of cryptotanshinone and tanshinone IIA, among D10, D50, D90, there were relatively strong correlation between the bulk density and tapped density, between the Hausner ratio and compressibility index. The angle of repose had a certain correlation with the uniformity, Hausner ratio and compressibility index, but with no strong correlation. The correlation coefficient between two sets was below 0.400, suggesting there was a not so good inter-group correlation. After the canonical correlation analysis, three pairs of canonical variables had significant correlations with correlation coefficients being0.851, 0.674 and 0.565, respectively. It was concluded that there was a good intraclass correlation for each of physical and/or chemical quality set, but the correlation between the two sets was bad. Canonical variables performed better inter-group correlation compared with original variables, indicating there was a certain correlation between chemical and physical quality attributes of tanshinone extract powders.
引文
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2 邵萌,王英,翦雨青,等.番石榴叶乙醇提取物的化学成分研究.中国中药杂志,2014,39(6):1021-1029.
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7 汪海鸿,狄留庆,赵晓莉,等.中药制剂中间提取物制备工艺路线设计思路探讨-通塞脉微丸中间提取物制备工艺比较研究.世界科学与技术-中医药现代化,2011,13(2):232-239.
8 鹿丽丽,萧伟,徐连明,等.不同粒径三七粉物理性质及体外溶出度的比较研究.世界科学与技术-中医药现代化,2013,15(2):305-309.
9 赵立杰,冯怡,徐德生,等.基于多元数据分析研究中药制剂原料吸湿性与其他物理特性的相关性.药学学报,2012,47(4):517-521.
10 李洁,杜若飞,冯怡,等.中药浸膏粉物理性质与干法制粒工艺相关性研究.中国中药杂志,2011,36(12):1606-1609.
11 李姝琦,冯怡,徐德生,等.影响粉末直接压片的中药提取物物理性质研究.中国药学杂志,2010,45(8):608-611.
12 杨胤,冯怡,徐德生,等.干燥工艺与中药提取物物理性质的相关性研究.中国药学杂志,2008,43(17):1295-1299.
13 杜焰,赵立杰,熊耀坤,等.药用粉体流动性的多元分析方法表征.药学学报,2012,47(9):1231-1236.
14 杜焰,冯怡,徐德生,等.基于主成分分析的中药粉体流动性表征研究.中成药,2012,34(7):1258-1263.
15 杜焰,赵立杰,冯怡,等.中药粉体流动性表征方法研究.中国中药杂志,2012,37(5):589-593.
16 胡荣峰,吕兴萍,张利,等.不同干燥工艺的六味地黄提取物的粉体学性能评价.中国生化药物杂志,2012,33(5):594-596.
2 邵萌,王英,翦雨青,等.番石榴叶乙醇提取物的化学成分研究.中国中药杂志,2014,39(6):1021-1029.
3 李云,萧伟,秦建平,等.HPLC同时测定龙血竭及其提取物中5个有效成分的含量.中国中药杂志,2012,37(7):929-933.
4 何雅君,苏娟,杨茜,等.HPLC同时测定山楂提取物中绿原酸和牡荆素鼠李糖苷的含量.中国中药杂志,2012,37(6):829-831.
5 向大雄,贺伏元,桑商斌,等.表征中药浸膏粉体特征的参数体系的建立及其在中药固体制剂质量评价中的意义.中医药学术发展大会论文集,2005:569-572.
6 徐德生,冯怡,张宁,等.中药提取物物理性质评价与改性技术研究的探索.世界科学技术-中医药现代化,2006,8(3):57-61.
7 汪海鸿,狄留庆,赵晓莉,等.中药制剂中间提取物制备工艺路线设计思路探讨-通塞脉微丸中间提取物制备工艺比较研究.世界科学与技术-中医药现代化,2011,13(2):232-239.
8 鹿丽丽,萧伟,徐连明,等.不同粒径三七粉物理性质及体外溶出度的比较研究.世界科学与技术-中医药现代化,2013,15(2):305-309.
9 赵立杰,冯怡,徐德生,等.基于多元数据分析研究中药制剂原料吸湿性与其他物理特性的相关性.药学学报,2012,47(4):517-521.
10 李洁,杜若飞,冯怡,等.中药浸膏粉物理性质与干法制粒工艺相关性研究.中国中药杂志,2011,36(12):1606-1609.
11 李姝琦,冯怡,徐德生,等.影响粉末直接压片的中药提取物物理性质研究.中国药学杂志,2010,45(8):608-611.
12 杨胤,冯怡,徐德生,等.干燥工艺与中药提取物物理性质的相关性研究.中国药学杂志,2008,43(17):1295-1299.
13 杜焰,赵立杰,熊耀坤,等.药用粉体流动性的多元分析方法表征.药学学报,2012,47(9):1231-1236.
14 杜焰,冯怡,徐德生,等.基于主成分分析的中药粉体流动性表征研究.中成药,2012,34(7):1258-1263.
15 杜焰,赵立杰,冯怡,等.中药粉体流动性表征方法研究.中国中药杂志,2012,37(5):589-593.
16 胡荣峰,吕兴萍,张利,等.不同干燥工艺的六味地黄提取物的粉体学性能评价.中国生化药物杂志,2012,33(5):594-596.