同型半胱氨酸与静脉血栓栓塞症相关性的研究进展
摘要
<正>静脉血栓栓塞症是一种常见的疾病,其中急性肺栓塞属于临床急危重症,存在较高的误诊率和漏诊率。近有研究表明高同型半胱氨酸血症是静脉血栓栓塞症的一项危险因素,在没有条件行计算机断层摄影肺血管造影或者肺核素灌注通气等检查确诊肺栓塞的基层医院,通过对血浆同型半胱氨酸水平的检测能帮助基层医生对该病进行初筛及预后评估,大大降低了医疗成本。本文就两者之间的相关性做一综述。一、静脉血栓栓塞症静脉血栓栓塞症(Venous Thromboembolism,
引文
[1]杨义春,张丽琴.肺栓塞的诊断进展[J].沈阳医学院学报,2018,20(1):80-84.
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[6]戴卫健,赵洪灿,项国谦.血清同型半胱氨酸和载脂蛋白水平检测及相关性分析[J].心脑血管病防治,2016,16(2):150-152.
[7]LI X,WENG L,HAN B,et al.Association of folate metabolism gene polymorphisms and haplotype combination with pulmonary embolism risk in Chinese Han population[J].Mamm Genome,2017,28(5/6):220-226.
[8]BEZGIN T,KAYMAZ C,AKBAL,et al.Thrombophilic gene mutations in relation to different manifestations of venous thromboembolism:a single tertiary center study[J].Clin Appl Thromb Hemost,2018,24(1):100-106.
[9]LI Z,YADAV U,MAHEMUTI A,et al.Association of MTHFR genetic polymorphisms with venous thromboembolism in Uyghur population in Xinjiang,China[J].Int J Clin Exp Med,2015,8(10):17703-17711.
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[12]KARALEZLI A,PARLAK E S,KANBAY A,et al.Homocysteine and serum-lipid levels in pulmonary embolism[J].Clin Appl Thromb Hemost,2011,17(6):E186-E189.
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[14]YANG F,QI X,GAO Z,et al.Homocysteine injures vascular endothelial cells by inhibiting mitochondrial activity[J].Exp Ther Med,2016,12(4):2247-2252.
[15]SALLES-CRAWLEY I I,MONKMAN J H,AHNSTRM J,et al.Vessel wall BAMBI contributes to hemostasis and thrombus stability[J].Blood,2014,123(18):2873-2881.
[16]乔云飞,李允模.同型半胱氨酸在呼吸系统疾病中的研究进展[J].医学综述,2016,22(6):1077-1080.
[17]KKTRK N,KANBAY A,AYDOˇGDU M,et al.Hyperhomocysteinemia prevalence among patients with venous thromboembolism[J].Clin Appl Thromb Hemost,2011,17(5):487-493.
[18]BHARGAVA S,ALI A,KANKRA M,et al.Differential expression of lipid peroxidation and total antioxidant status in Indian patients with cardiovascular and cerebrovascular disease[J].Can J Physiol Pharmacol,2014,92(7):592-597.
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[21]吴章明.高同型半胱氨酸血症与血栓形成的相关性研究进展[J].齐齐哈尔医学院学报,2016,37(29):3689-3690.
[22]PETRAS M,TATARKOVA Z,KOVALSKA M,et al.Hyperhomocysteinemia as a risk factor for the neuronal system disorders[J].JPhysiol Pharmacol,2014,65(1):15-23.
[23]MURUGESAN V,PULIMAMIDI V K,RAJAPPA M,et al.Elevated fibrinogen and lowered homocystein-vitamin determinants and their association with left atrial thrombus in patients with rheumatic mitral slenosis[J].Br J Biomed Sci,2015,72(3):102-106.
[24]KYRLE P A,EISCHER L.Predicting the risk of recurrent venous thromboembolism.The Austrian study on recurrent venous thromboembolism(AUREC)[J].Hamostaseologie,2013,33(3):201-209.
[25]CELLAI A P,LAMI D,ANTONUCCI E,et al.Hyperhomocysteinemia in patients with?pulmonary embolism is associated with impaired plasma fibrinolytic capacity[J].J Thromb Thrombolysis,2014,38(1):45-49.
[26]褚非非.联合检测D-二聚体、B型尿钠肽及同型半胱氨酸在肺栓塞早期诊断中的临床价值[J].实用临床医药杂志,2015,19(24):143,151.
[27]TODUA F,AKHVLEDIANI M,VOROBIOVA E,et al.Prognostic value of some hemostasis-related,homocysteine,high sensitive CRPand multidetector computed tomography parameters in pulmonary embolism[J].Georgian Med News,2016,(254):37-42.
[28]陈明荣.血同型半胱氨酸D-二聚体及hs-CRP联合检测在急性肺栓塞诊断中的价值[J/OL].中西医结合心血管病电子杂志,2016,4(15):37-38.
[29]王增明,王金红,殷红艳,等.血浆同型半胱氨酸、C反应蛋白与D二聚体对创伤骨折肺栓塞患者诊断及预后判断的价值[J].解放军医药杂志,2016,28(10):104-106.
[30]吴越.HCY、D二聚体、血氧指标对老年肺栓塞的临床意义[D].昆明:昆明医科大学,2016.
[31]张英民,毛毅敏,孙瑜霞.血清同型半胱氨酸和急性肺栓塞患者死亡的关系[J].武汉大学学报(医学版),2015,36(2):299-302.
[32]冯慧远,李伟伟.血清同型半胱氨酸水平与老年急性肺栓塞患者早期死亡的相关性[J].中华实用诊断与治疗杂志,2015,29(5):491-493.
[33]朱航,薛浩,王广义,等.血清同型半胱氨酸水平与急性肺栓塞患者早期死亡的相关性[J].中华心血管病杂志,2013,41(9):756-760.
[34]谭榜云,陈新年,刘志武,等.Hcy、v W F及D-D联合检测对下肢深静脉血栓形成的诊断价值[J].检验医学与临床,2016,13(21):3019-3020.
[2]MASSIMO M,CATERINA C,SIMONETTA M,et al.Clinical presentation of acute pulmonary embolism:survey of 800 cases[J].PLo S One,2012,7(2):e30891.
[3]REITTER-PFOERTNER S,WALDHOER T,MAYERHOFER M,et al.The influence of thrombophilia on the long-term survival of patients with a history of venous thromboembolism[J].Thromb Hemost,2013,109(1):79-84.
[4]CULAFI'CD M,MARKOVI'CM L,OBRENOVI'CR Z,et al.Plasma homocysteine levels in patients with liver cirrhosis[J].Vojnosanit Pregl,2013,70(1):57-60.
[5]程丝,冯娟,王宪.高同型半胱氨酸血症治疗研究进展[J].生理科学进展,2011,42(5):329-334.
[6]戴卫健,赵洪灿,项国谦.血清同型半胱氨酸和载脂蛋白水平检测及相关性分析[J].心脑血管病防治,2016,16(2):150-152.
[7]LI X,WENG L,HAN B,et al.Association of folate metabolism gene polymorphisms and haplotype combination with pulmonary embolism risk in Chinese Han population[J].Mamm Genome,2017,28(5/6):220-226.
[8]BEZGIN T,KAYMAZ C,AKBAL,et al.Thrombophilic gene mutations in relation to different manifestations of venous thromboembolism:a single tertiary center study[J].Clin Appl Thromb Hemost,2018,24(1):100-106.
[9]LI Z,YADAV U,MAHEMUTI A,et al.Association of MTHFR genetic polymorphisms with venous thromboembolism in Uyghur population in Xinjiang,China[J].Int J Clin Exp Med,2015,8(10):17703-17711.
[10]IBRAHIM S,MAQBOOL S,AZAM M,et al.CBS mutations and MTFHR SNPs causative of hyperhomocysteinemia in Pakistani children[J].Mol Biol Rep,2018,45(3):353-360.
[11]HE X,MAO Y,HE J.Related research between acute inflammatory reaction and hemodynamic changes of pulmonary embolism rabbit with hyperhomocysteinemia[J].Zhonghua Yi Xue Za Zhi,2015,95(46):3758-3761.
[12]KARALEZLI A,PARLAK E S,KANBAY A,et al.Homocysteine and serum-lipid levels in pulmonary embolism[J].Clin Appl Thromb Hemost,2011,17(6):E186-E189.
[13]井河江.高半胱氨酸血症对急性肺栓塞血流动力学及炎性细胞因子变化的实验研究[D].洛阳:河南科技大学,2014.
[14]YANG F,QI X,GAO Z,et al.Homocysteine injures vascular endothelial cells by inhibiting mitochondrial activity[J].Exp Ther Med,2016,12(4):2247-2252.
[15]SALLES-CRAWLEY I I,MONKMAN J H,AHNSTRM J,et al.Vessel wall BAMBI contributes to hemostasis and thrombus stability[J].Blood,2014,123(18):2873-2881.
[16]乔云飞,李允模.同型半胱氨酸在呼吸系统疾病中的研究进展[J].医学综述,2016,22(6):1077-1080.
[17]KKTRK N,KANBAY A,AYDOˇGDU M,et al.Hyperhomocysteinemia prevalence among patients with venous thromboembolism[J].Clin Appl Thromb Hemost,2011,17(5):487-493.
[18]BHARGAVA S,ALI A,KANKRA M,et al.Differential expression of lipid peroxidation and total antioxidant status in Indian patients with cardiovascular and cerebrovascular disease[J].Can J Physiol Pharmacol,2014,92(7):592-597.
[19]BREZOVSKA-KAVRAKOVA J,KRSTEVSKA M,BOSILKOVA G,et al.Hyperhomocysteinemia and of methylenetetrahydrofolate reductase(C677T)genetic polymorphism in patients with deep vein thrombosis[J].Mater Sociomed,2013,25(3):170-174.
[20]SULE A A,CHIN T J,KHIEN L H.Recurrent unprovoked venous thromboembolism in a young female patient with high levels of homocysteine[J].Int J Angiol,2012,21(2):95-98.
[21]吴章明.高同型半胱氨酸血症与血栓形成的相关性研究进展[J].齐齐哈尔医学院学报,2016,37(29):3689-3690.
[22]PETRAS M,TATARKOVA Z,KOVALSKA M,et al.Hyperhomocysteinemia as a risk factor for the neuronal system disorders[J].JPhysiol Pharmacol,2014,65(1):15-23.
[23]MURUGESAN V,PULIMAMIDI V K,RAJAPPA M,et al.Elevated fibrinogen and lowered homocystein-vitamin determinants and their association with left atrial thrombus in patients with rheumatic mitral slenosis[J].Br J Biomed Sci,2015,72(3):102-106.
[24]KYRLE P A,EISCHER L.Predicting the risk of recurrent venous thromboembolism.The Austrian study on recurrent venous thromboembolism(AUREC)[J].Hamostaseologie,2013,33(3):201-209.
[25]CELLAI A P,LAMI D,ANTONUCCI E,et al.Hyperhomocysteinemia in patients with?pulmonary embolism is associated with impaired plasma fibrinolytic capacity[J].J Thromb Thrombolysis,2014,38(1):45-49.
[26]褚非非.联合检测D-二聚体、B型尿钠肽及同型半胱氨酸在肺栓塞早期诊断中的临床价值[J].实用临床医药杂志,2015,19(24):143,151.
[27]TODUA F,AKHVLEDIANI M,VOROBIOVA E,et al.Prognostic value of some hemostasis-related,homocysteine,high sensitive CRPand multidetector computed tomography parameters in pulmonary embolism[J].Georgian Med News,2016,(254):37-42.
[28]陈明荣.血同型半胱氨酸D-二聚体及hs-CRP联合检测在急性肺栓塞诊断中的价值[J/OL].中西医结合心血管病电子杂志,2016,4(15):37-38.
[29]王增明,王金红,殷红艳,等.血浆同型半胱氨酸、C反应蛋白与D二聚体对创伤骨折肺栓塞患者诊断及预后判断的价值[J].解放军医药杂志,2016,28(10):104-106.
[30]吴越.HCY、D二聚体、血氧指标对老年肺栓塞的临床意义[D].昆明:昆明医科大学,2016.
[31]张英民,毛毅敏,孙瑜霞.血清同型半胱氨酸和急性肺栓塞患者死亡的关系[J].武汉大学学报(医学版),2015,36(2):299-302.
[32]冯慧远,李伟伟.血清同型半胱氨酸水平与老年急性肺栓塞患者早期死亡的相关性[J].中华实用诊断与治疗杂志,2015,29(5):491-493.
[33]朱航,薛浩,王广义,等.血清同型半胱氨酸水平与急性肺栓塞患者早期死亡的相关性[J].中华心血管病杂志,2013,41(9):756-760.
[34]谭榜云,陈新年,刘志武,等.Hcy、v W F及D-D联合检测对下肢深静脉血栓形成的诊断价值[J].检验医学与临床,2016,13(21):3019-3020.