血管性痴呆給予丁苯酞軟膠囊治療的臨床分析
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摘要
目的分析血管性痴呆给予丁苯酞软胶囊治疗的临床效果。方法随机选取2017年1月—2018年3月期间该院收治的200例血管性痴呆患者,随机双盲法分为两组,其中100例患者为对照组,临床治疗选择尼莫地平治疗;100例患者为观察组,临床治疗选择丁苯酞软胶囊治疗;两组患者连续治疗6个月,对比两组患者治疗前后认知功能变化。结果 (1)总有效率:观察组为98.00%,高于对照组的82.00%,差异有统计学意义(χ~2=12.500,P=0.0000);(2)治疗后MMSE评分比较:观察组(27.42±2.36)分高于对照组的(23.58±2.87)分,差异有统计学意义(t=5.190,P=0.000);(3)治疗ADL评分比较:观察组的(84.62±6.73)分高于对照组的(71.36±7.84)分,差异有统计学意义(t=12.833,P=0.000);(4)不良反应:观察组为3.00%,高于对照组的18.00%,差异有统计学意义(χ~2=10.428,P=0.001)。结论丁苯酞软胶囊治疗血管性痴呆,患者认知功能明显改善,效果显著,值得临床推广。
Objective To analyze the clinical effect of butylphthalide soft capsules in treatment of vascular dementia.Methods 200 cases of patients with vascular dementia admitted and treated in our hospital from January 2017 to March 2018 were selected and randomly divided into two groups with 100 in each, the control group were treated with nimodipine, while the observation group were treated with butylphthalide soft capsules, and the two groups were treated for 6 months, and the cognitive function changes before and after treatment were compared between the two groups.Results 1.The total treatment effective rate in the observation group was higher than that in the control group,(98.00%vs 82.00%), and the difference was obvious(χ~2=12.500, P=0.0000); 2.after treatment, the MMSE score in the observation group was higher than that in the control group[(27.42±2.36)points vs(23.58±2.87)points,(t=5.190, P=0.000)]; 3.and the ADL score in the observation group was higher than that in the control group[(84.62±6.73)points vs(71.36±7.84)points,(t=12.833, P=0.000)]; 4.and the adverse reactions in the observation group was higher than that in the control group(3.00% vs 18.00%), and the difference was statistically significant(χ~2=10.428, P =0.001). Conclusion The butylphthalide soft capsules in treatment of vascular dementia can obviously improve the cognitive function, and the effect is obvious, and it is worth clinical promotion.
Objective To analyze the clinical effect of butylphthalide soft capsules in treatment of vascular dementia.Methods 200 cases of patients with vascular dementia admitted and treated in our hospital from January 2017 to March 2018 were selected and randomly divided into two groups with 100 in each, the control group were treated with nimodipine, while the observation group were treated with butylphthalide soft capsules, and the two groups were treated for 6 months, and the cognitive function changes before and after treatment were compared between the two groups.Results 1.The total treatment effective rate in the observation group was higher than that in the control group,(98.00%vs 82.00%), and the difference was obvious(χ~2=12.500, P=0.0000); 2.after treatment, the MMSE score in the observation group was higher than that in the control group[(27.42±2.36)points vs(23.58±2.87)points,(t=5.190, P=0.000)]; 3.and the ADL score in the observation group was higher than that in the control group[(84.62±6.73)points vs(71.36±7.84)points,(t=12.833, P=0.000)]; 4.and the adverse reactions in the observation group was higher than that in the control group(3.00% vs 18.00%), and the difference was statistically significant(χ~2=10.428, P =0.001). Conclusion The butylphthalide soft capsules in treatment of vascular dementia can obviously improve the cognitive function, and the effect is obvious, and it is worth clinical promotion.
引文
[1]胡浩.丁苯酞软胶囊对改善血管性痴呆患者认知功能的疗效及作用机制分析[J].中国实用神经疾病杂志,2017,20(1):98-99.
[2]贾建平,王树英.血管性痴呆临床诊断标准探讨[J].中国神经免疫学和神经病学杂志, 2010, 17(6):387-389.
[3]高明月,杨珉,况伟宏,等.简易精神状态量表得分的影响因素和正常值的筛查效度评价[J].北京大学学报:医学版, 2015, 47(3):443-449.
[4]刘帅,柳净,陈慧,等.阿尔茨海默病与血管性痴呆患者认知及日常生活能力对比分析[J].山东医药, 2015(19):32-34.
[5]田金洲,韩明向,涂晋文,等.血管性痴呆的诊断、辨证及疗效判定标准[J].北京中医药大学学报, 2000, 23(5):16-24.
[6]孙晓鸣,鲍君杰,张华,等.丁苯酞对血管性痴呆大鼠记忆功能及海马神经元代谢产物的影响[J].中国生化药物杂志,2015, 35(2):84-87.
[7]程文姚,杨健,余新沛,等.丁苯酞软胶囊与尼莫地平对卒中后血管性痴呆患者的疗效[J].解放军预防医学杂志,2016,34(4):516-518.
[2]贾建平,王树英.血管性痴呆临床诊断标准探讨[J].中国神经免疫学和神经病学杂志, 2010, 17(6):387-389.
[3]高明月,杨珉,况伟宏,等.简易精神状态量表得分的影响因素和正常值的筛查效度评价[J].北京大学学报:医学版, 2015, 47(3):443-449.
[4]刘帅,柳净,陈慧,等.阿尔茨海默病与血管性痴呆患者认知及日常生活能力对比分析[J].山东医药, 2015(19):32-34.
[5]田金洲,韩明向,涂晋文,等.血管性痴呆的诊断、辨证及疗效判定标准[J].北京中医药大学学报, 2000, 23(5):16-24.
[6]孙晓鸣,鲍君杰,张华,等.丁苯酞对血管性痴呆大鼠记忆功能及海马神经元代谢产物的影响[J].中国生化药物杂志,2015, 35(2):84-87.
[7]程文姚,杨健,余新沛,等.丁苯酞软胶囊与尼莫地平对卒中后血管性痴呆患者的疗效[J].解放军预防医学杂志,2016,34(4):516-518.