骨性关节炎相关滑膜炎症研究进展
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摘要
骨性关节炎(osteoarthritis,OA)是影响滑膜关节(膝,髋,手指远端,脊柱关节)的常见慢性退行性疾病,病变常常影响整个关节组织,以关节软骨的降解、关节边缘骨赘形成和滑膜病变为特征。以往的研究和治疗重点大多在关节软骨病变,而越来越多的研究显示滑膜的炎性病变在骨性关节炎整个病程中起重要作用,滑膜炎症以及与滑膜相关的致炎因子诱导的关节软骨的降解和破坏,促进了骨性关节炎的发展。滑膜病变在骨性关节炎的发生发展中扮演了重要角色,因此,滑膜炎症可以作为骨性关节炎治疗的一个关键靶点。
Osteoarthritis(OA) is a common chronic degenerative disease affecting synovial joints(knee,hip, distal finger, spinal joint). Lesions often affect the entire joint tissue, with the degradation of articular cartilage, joint bone Ankle formation and synovial lesions are characteristic. Most of the previous research and treatment focuses on articular cartilage lesions, more and more studies have shown that inflammatory lesions of the synovial membrane play an important role in the whole course of osteoarthritis,synovial inflammation and induction of inflammatory factors associated with synovium. The degradation and destruction of articular cartilage promotes the development of osteoarthritis. Synovial lesions play an important role in the development of osteoarthritis. Therefore,synovial inflammation can be a key target for the treatment of osteoarthritis.
Osteoarthritis(OA) is a common chronic degenerative disease affecting synovial joints(knee,hip, distal finger, spinal joint). Lesions often affect the entire joint tissue, with the degradation of articular cartilage, joint bone Ankle formation and synovial lesions are characteristic. Most of the previous research and treatment focuses on articular cartilage lesions, more and more studies have shown that inflammatory lesions of the synovial membrane play an important role in the whole course of osteoarthritis,synovial inflammation and induction of inflammatory factors associated with synovium. The degradation and destruction of articular cartilage promotes the development of osteoarthritis. Synovial lesions play an important role in the development of osteoarthritis. Therefore,synovial inflammation can be a key target for the treatment of osteoarthritis.
引文
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[17]O'NEIL T W,PARKES M J,MARICAR N,et al.Synovial tissue volume:a treatment target in knee osteoarthritis(OA)[J].Annals of the Rheumatic Diseases,2016,75(1):84-90.
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[19]ROBINSON P,KEENAN A M,CONAGHAN P G,et al.Clinical effectiveness and dose response of image-guided intra-articular corticosteroid injection for hip osteoarthritis[J].Rheumatology,2007,46(2):285.
[20]WENHAM C Y,HENSOR E M,GRAINGER A J,et al.A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis[J].Rheumatology,2012,51(12):2286-2294.
[21]CONAHAN P G,HUNTER D J,COHENS B,et al.Effects of a single intra-articular injection of a microsphere formulation of triamcinolone acetonide on knee osteoarthritis pain:A double-blinded,randomized,placebo-controlled,multinational study[J].J Bone Joint Surg Am,2018,100(8):666-677.
[22]龚春柱,张卫红,张军波,等.中药口服外敷治疗膝关节慢性滑膜炎临床观察[J].中医药通报,2016,15(5):57-59.
[23]WENHAM C Y,GRAINGE A J,HENSOR E M,et al.Methotrexate for pain relief in knee osteoarthritis:an open-label study[J].Rheumatology,2013,52(5):888-892.
[24]WENHAM C Y,MCDERMOTT M,CONAGHAN P G.Biological therapies in osteoarthritis[J].Current Pharmaceutical Design,2015,21(17):2206-2215.
[2]THOMAS E,PEAT G,CROFT P,et al. Defining and mapping the person with osteoarthritis for population studies and public health[J].Rheumatology,2014,53(2):338-345.
[3]PRIETO-POTIN I,LARGO R,ROMAN-BLAS J A,et al.Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis[J].Bmc Musculoskeletal Disorders,2015,16(1):1-10.
[4]DELIGNNE C,CASULLI S,PIGENET A,et al. Differential expression of interleukin-17 and interleukin-22 in inflamed and non-inflamed synovium from osteoarthritis patients[J].Osteoarthritis&Cartilage,2015,23(11):1843-1852.
[5]GOLDRING M B.Chondrogenesis,chondrocyte differentiation,and articular cartilage metabolism in health and osteoarthritis[J].Ther Adv Musculoskelet Dis,2012,4(4):269-285.
[6]BERENBARM F. Osteoarthritis as an inflammatory disease(osteoarthritis is not osteoarthrosis!)[J].Osteoarthritis&Cartilage,2013,21(1):16-21.
[7]PONCHEL F,BURSKA A N,HENSOR E M,et al.Changes in peripheral blood immune cell composition in osteoarthritis[J].Osteoarthritis&Cartilage,2015,23(11):1870.
[8]SIEBUHR A S,BAY-JENSEN A C,JORDAN J M,et al.Inflammation(or synovitis)-driven osteoarthritis:an opportunity for personalizing prognosis and treatment[J].Scandinavian Journal of Rheumatology,2016,45(2):87.
[9]GUERMAZI A,ROEMER F W,HAUGEN I K,et al.MRI-based semiquantitative scoring of joint pathology in osteoarthritis[J].Nature Reviews Rheumatology,2013,9(4):236-251.
[10]DE LANGE-BROKAAR B J,IOAN-FACSINAY A,YUSUF E,et al.Degree of synovitis on MRI by comprehensive whole knee semi-quantitative scoring method correlates with histologic and macroscopic features of synovial tissue inflammation in knee osteoarthritis[J].Osteoarthritis&Cartilage,2014,22(10):1606-1613.
[11]NEOGI T,GUERMAZI A,ROEMER F,et al.Association of joint inflammation with painsensitization inknee osteoarthritis:The multicenter osteoarthritis study[J].Arthritis&Rheumatology,2016,68(3):654.
[12]GUERMAZI A,HAYASHI D,ROEMER F W,et al.Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging(MRI)is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage:the MOST study[J].Journal of Rheumatology,2014,41(3):501-508.
[13]HAUGEN I K,BYESEN P,SLATKOWSKY-CHRISTENSEN B,et al.Kvien.Associations between MRI-defined synovitis,bone marrow lesions and structural features and measures of pain and physical function in hand osteoarthritis[J].Annals of the Rheumatic Diseases,2012,71(6):899.
[14]SARMANOVA A,HALL M,MOSES J,et al. Synovial changes detected by ultrasound in people with knee osteoarthritis-a meta-analysis of observational studies[J].Osteoarthritis&Cartilage,2016,24(8):1376-1383.
[15]D'AGOSTINO M A,CONAGHAN P,LE BARS M,et al.EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1:Prevalence of inflammation in osteoarthritis[J].Annals of the Rheumatic Diseases,2005,64(12):1703-1709.
[16]MATHIESSEN A,SLATKOWSKY-CHRISTENSEN B,KVIEN T K,et al.Ultrasound-detected inflammation predicts radiographic progression in hand osteoarthritis after 5years[J].Annals of the Rheumatic Diseases,2016,75(5):825-830.
[17]O'NEIL T W,PARKES M J,MARICAR N,et al.Synovial tissue volume:a treatment target in knee osteoarthritis(OA)[J].Annals of the Rheumatic Diseases,2016,75(1):84-90.
[18]ZHANG W,NUKI G,MOSKOWITZ R W,et al. OARSI recommendations for the management of hip and knee osteoarthritis:Part III:Changes in evidence following systematic cumulative update of research published through January[J].Osteoarthritis&Cartilage,2010,18(4):476-499.
[19]ROBINSON P,KEENAN A M,CONAGHAN P G,et al.Clinical effectiveness and dose response of image-guided intra-articular corticosteroid injection for hip osteoarthritis[J].Rheumatology,2007,46(2):285.
[20]WENHAM C Y,HENSOR E M,GRAINGER A J,et al.A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis[J].Rheumatology,2012,51(12):2286-2294.
[21]CONAHAN P G,HUNTER D J,COHENS B,et al.Effects of a single intra-articular injection of a microsphere formulation of triamcinolone acetonide on knee osteoarthritis pain:A double-blinded,randomized,placebo-controlled,multinational study[J].J Bone Joint Surg Am,2018,100(8):666-677.
[22]龚春柱,张卫红,张军波,等.中药口服外敷治疗膝关节慢性滑膜炎临床观察[J].中医药通报,2016,15(5):57-59.
[23]WENHAM C Y,GRAINGE A J,HENSOR E M,et al.Methotrexate for pain relief in knee osteoarthritis:an open-label study[J].Rheumatology,2013,52(5):888-892.
[24]WENHAM C Y,MCDERMOTT M,CONAGHAN P G.Biological therapies in osteoarthritis[J].Current Pharmaceutical Design,2015,21(17):2206-2215.