银杏二萜内酯葡胺注射液联合常规西医治疗脑梗死的效果评价
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摘要
目的探讨银杏二萜内酯葡胺注射液联合常规西医治疗在脑梗死患者中的治疗效果。方法选取2016年4月至2018年4月于我院进行治疗的62例动脉粥样硬化性血栓性脑梗死恢复期患者,随机分为观察组和对照组,每组31人。对照组给予常规西医治疗,观察组在对照组治疗的基础上给予银杏二萜内酯葡胺注射液治疗。比较两组患者脑部平均血流速度、神经功能缺损评分变化以及不良反应发生情况。结果治疗前两组患者脑部平均血流速度、神经功能缺损评分无统计学差异(P> 0. 05),和治疗前比较,治疗后两组患者脑部平均血流速度、神经功能缺损评分均有改善(P <0. 05),且观察组患者脑部平均血流速度、神经功能缺损评分改善更为显著(P <0. 05)。结论银杏二萜内酯葡胺注射液联合常规西医治疗用于脑梗死患者的治疗,能够显著改善患者脑部平均血流速度以及神经功能缺损评分,药物安全性高,具有临床推广的重要意义。
Objective To explore clinical efficacy of the Ginkgo biloba diterpene lactone meglumine injection with routine western medicine therapy in the treatment of cerebral infarction. Methods 62 patients with atherosclerotic thrombotic cerebral infarction in the recovery period from April 2016 to April 2018 were randomly divided into the observation group and the control group,with 31 in each group. The control group was given conventional western medicine treatment,while the observation group was given ginkgolide two diterpene lactone injection on the basis of the control group’s treatment. The mean blood flow velocity,neurological deficit score and the incidence of adverse reactions were compared between the two groups.Results There was no statistical difference in mean blood flow velocity and brain neural function defect between the two groups before treatment( P > 0. 05). After treatment,there was improvement in brain average blood flow velocity and neural function defect in both groups( P < 0. 05). And there was more significant improvement in average blood flow velocity and brain nerve function defect in the observation group( P < 0. 05). Conclusion Ginkgo biloba diterpene lactone meglumine injection combined with conventional western medicine for the treatment of cerebral infarction patients can significantly improve the average velocity of blood flow in the brain and the score of nerve function defect,and the drug is sufficiently safe and thus worth clinical promotion.
Objective To explore clinical efficacy of the Ginkgo biloba diterpene lactone meglumine injection with routine western medicine therapy in the treatment of cerebral infarction. Methods 62 patients with atherosclerotic thrombotic cerebral infarction in the recovery period from April 2016 to April 2018 were randomly divided into the observation group and the control group,with 31 in each group. The control group was given conventional western medicine treatment,while the observation group was given ginkgolide two diterpene lactone injection on the basis of the control group’s treatment. The mean blood flow velocity,neurological deficit score and the incidence of adverse reactions were compared between the two groups.Results There was no statistical difference in mean blood flow velocity and brain neural function defect between the two groups before treatment( P > 0. 05). After treatment,there was improvement in brain average blood flow velocity and neural function defect in both groups( P < 0. 05). And there was more significant improvement in average blood flow velocity and brain nerve function defect in the observation group( P < 0. 05). Conclusion Ginkgo biloba diterpene lactone meglumine injection combined with conventional western medicine for the treatment of cerebral infarction patients can significantly improve the average velocity of blood flow in the brain and the score of nerve function defect,and the drug is sufficiently safe and thus worth clinical promotion.
引文
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[8]周莉,高颖,赖新星,等.银杏二萜内酯葡胺注射液用于6300例缺血性脑卒中患者的上市后临床安全性再评价研究[J].中国中药杂志,2017,42(24):4744-4749.
[9]王传明,杨春水,李雯飞,等.静脉溶栓与机械取栓治疗急性脑梗死的临床疗效观察[J].现代医院,2015,15(8):15-17.
[10]赵宾江,王振中,凌娅,等.银杏二萜内酯葡胺注射液治疗动脉粥样硬化性血栓性脑梗死恢复期(痰瘀阻络证)Ⅲ期临床试验[J].中草药,2013,44(24):3525-3530.
[11]李迪,邵尉,台宗光,等.依达拉奉联合银杏二萜内酯葡胺注射液治疗急性脑梗死的临床疗效观察[J].药学实践杂志,2018,36(1):80-82.
[12]李守林,周伟,朱小浩,等.依达拉奉联合银杏二帖内酯葡胺注射液治疗急性脑梗死的疗效观察[J].临床医学研究与实践,2017,2(18):35-36.
[13]肖展翅,倪小红,李钢,等.银杏二萜内酯葡胺注射液对脑梗死恢复期患者血液流变学的影响[J].中西医结合心脑血管病杂志,2015(16):1828-1830.
[14]仲崇金,华骏,陈萌,等.银杏二萜内酯葡胺注射液对缺血性脑卒中急性期损伤的保护作用[J].药物评价研究,2017,40(6):752-758.
[15]蓝桂彬,赖春进,宁丽晔.银杏叶提取物注射液治疗老年缺血性脑血管病的疗效与安全性[J].中国医药科学,2018,8(3):86-88.
[2]THIAN Y L,RIDDELL A M,KOH D M.Liver-specific agents for contrast-enhanced MRI:role in oncological imaging[J].Cancer Imaging,2013,13(4):567-579.
[3]张雯,宋俊科,何国荣,等.银杏二萜内酯对缺血/再灌注大鼠脑组织中神经递质的影响[J].中国药理学通报,2016,32(12):1648-1656.
[4]王新德.各类脑血管疾病诊断要点[J].中华神经科杂志,1996(6):379-380.
[5]王北婴.中药治疗中风病的临床研究指导原则[J].中华中医药杂志,1988(4):70-72.
[6]邱斌,肖展翅.银杏二萜内酯葡胺注射液治疗急性脑梗死的临床观察[J].中西医结合心脑血管病杂志,2015,13(8):1033-1035.
[7]DING D Z,DING J S,JIN Z Y,et al.Evaluation of curative effect of meglumine cyclic adenylate combined with recombinant human brain natriuretic peptide in treatment of coronary artery disease patients with heart failure[J].Journal of Jilin University,2011,37(4):723-726.
[8]周莉,高颖,赖新星,等.银杏二萜内酯葡胺注射液用于6300例缺血性脑卒中患者的上市后临床安全性再评价研究[J].中国中药杂志,2017,42(24):4744-4749.
[9]王传明,杨春水,李雯飞,等.静脉溶栓与机械取栓治疗急性脑梗死的临床疗效观察[J].现代医院,2015,15(8):15-17.
[10]赵宾江,王振中,凌娅,等.银杏二萜内酯葡胺注射液治疗动脉粥样硬化性血栓性脑梗死恢复期(痰瘀阻络证)Ⅲ期临床试验[J].中草药,2013,44(24):3525-3530.
[11]李迪,邵尉,台宗光,等.依达拉奉联合银杏二萜内酯葡胺注射液治疗急性脑梗死的临床疗效观察[J].药学实践杂志,2018,36(1):80-82.
[12]李守林,周伟,朱小浩,等.依达拉奉联合银杏二帖内酯葡胺注射液治疗急性脑梗死的疗效观察[J].临床医学研究与实践,2017,2(18):35-36.
[13]肖展翅,倪小红,李钢,等.银杏二萜内酯葡胺注射液对脑梗死恢复期患者血液流变学的影响[J].中西医结合心脑血管病杂志,2015(16):1828-1830.
[14]仲崇金,华骏,陈萌,等.银杏二萜内酯葡胺注射液对缺血性脑卒中急性期损伤的保护作用[J].药物评价研究,2017,40(6):752-758.
[15]蓝桂彬,赖春进,宁丽晔.银杏叶提取物注射液治疗老年缺血性脑血管病的疗效与安全性[J].中国医药科学,2018,8(3):86-88.