奥拉西坦对神经系统疾病的治疗
摘要
<正>奥拉西坦(oxiracetam)是γ-氨基丁酸的环形衍生物,化学名为4-羟基-2-氧代-1-吡咯烷乙酰胺,属吡拉西坦类似物,是目前备受瞩目的吡咯烷酮类促智药(nootropics)。目前临床上,奥拉西坦主要用于治疗各种痴呆和器质性脑综合症,此外还用于治疗各种因素引起的脑损伤、脑缺氧和慢性脑功能不全,以及神经退行性病变引起的学习记忆衰退、老年精神衰退综合症、儿童智障等。
引文
[1]Mennin i T,Taddei C,Cagnotto A,et al.In-vivo radiolabelled oxiracetam binding to rat brain[J].J Pharm Pharmacol,1990,42(3):171-174.
[2]Pepeu G,Spignoli G.Nootropicdrugsandbrain cholinergicmechanisms[J].Prog Neuropsychopharmacol Biol Psychiatry,1989,13(Suppl):S77-S88.
[3]Fordyce DE,Clark VJ,Paylor R,et al.Enhancement of hippocampally-mediated learning and protein kinase Cactivity by oxiracetam in learning-impaired DBA/2 mice[J].Brain Res,1995,672(1-2):170-176.
[4]Mondadori C,Petschke F,Hausler A.The effects of nootropics on memory:new aspects for basic research[J].Pharmacopsychiatry,1989,22(Suppl2):102-106.
[5]Fagni L,Chavis P,Ango F,et al.Complex interactions between m Glu Rs,intracellular Ca2+stores and ion channels in neurons[J].Trends Neurosci,2000,23(2):80-88.
[6]De Angelis L,Furlan C.The effects of ascorbic acid and oxiracetam on scopolamine-induced amnesia in a habituation test in aged mice[J].Neurobiol Learn Mem,1995,64(2):119-124.
[7]Nakamoto Y,Shiotani T,Watabe S,et al.Nootropic nefiracetam inhibits proconvulsant action of peripheral-type benzodiazepines in epileptic mutant EL mice[J].Ann N Y Acad Sci,2004,1025:135-139.
[8]Hlinák Z,KrejcíI.Oxiracetam prevents the MK-801 induced amnesia for the elevated plus-maze in mice[J].Behav Brain Res,2000,117(1-2):147-151.
[9]Smith AM,Wehner JM.Aniracetam improves contextual fear conditioning and increases hippocampal gamma-PKC activation in DBA/2J mice[J].Hippocampus,2002,12(1):76-85.
[10]Hlinák Z,KrejcíI.Oxiracetam prevented the scopolamine but not the diazepam induced memory deficits in mice[J].Behav Brain Res,2002,133(2):395-399.
[11]Mondadori C,Ducret T,Petschke F.Blockade of the nootropic action of piracetam-like nootropics by adrenalectomy:an effect of dosage[J]?Behav Brain Res,1989,34(1-2):155-158.
[12]Rozzini R,Zanetti O,Bianchetti A.Treatment of cognitive impairment secondary to degenerative dementia.Effectiveness of oxiracetam therapy[J].Acta Neurol(Napoli),1993,15(1):44-52.
[13]赵桂萍,王荫华,赵玉宾,等.国产奥拉西坦治疗痴呆的临床评价[J].中国临床药理学杂志,1997,13(1):17-21.
[14]李建伟,杨东军,陈旭义,等.奥拉西坦对颅脑损伤大鼠的保护作用[J].中国应用生理学杂志,2013,29(4):298-300.
[15]朱继.奥拉西坦治疗轻中型脑伤的临床研究[J].第三军医大学学报,2006,28(10):1124-1125.
[16]刘中元.奥拉西坦治疗颅脑损伤临床效果观察[J].海峡药学,2012,24(2):97-98.
[17]于万水.奥拉西坦改善中型颅脑损伤患者神经功能缺失、记忆与智能障碍的疗效分析[J].中国伤残医学,2013,21(2):92-93.
[18]Kometani M,Okada M,Takemori E,et al.Effect of oxiracetam on cerebrovascular impairment in rats[J].Arzneimittelforschung,1991,41(7):684-689.
[19]Wang C,Li F,Guan Y,et al.Bone marrow stromal cells combined with oxiracetam influences the expression of B-cell lymphoma 2 in rats with ischemic stroke[J].J Stroke Cerebrovasc Dis,2014,23(10):2591-2597.
[20]丁绪平,马风杰,张学敏,等.奥拉西坦对脑出血大鼠的脑保护作用及对Caspase-3表达的影响[J].现代中西医结合杂志,2013,22(4):363-374.
[21]姚恺,邬军锋,杨晓波,等.神经保护剂治疗急性脑梗死患者的疗效及安全性[J].中国老年学杂志,2012,32(19):4137-4139.
[22]张亚兰.奥拉西坦与灯盏花素联合治疗急性脑梗死疗效分析[J].基层医学论坛,2015,19(27):3770-3772.
[23]刘军武.大面积脑梗塞予以奥拉西坦联合依达拉奉的临床疗效分析[J].黑龙江医学,2015,39(11):1274-1275.
[24]赵金凤.高血压脑出血患者应用奥拉西坦疗效观察[J].中国实用神经疾病杂志,2012,15(4):88-89.
[25]李繁云,李繁丽.高血压脑出血患者应用奥拉西坦效果分析[J].世界最新医学信息文摘,2015,15(61):106-110.
[2]Pepeu G,Spignoli G.Nootropicdrugsandbrain cholinergicmechanisms[J].Prog Neuropsychopharmacol Biol Psychiatry,1989,13(Suppl):S77-S88.
[3]Fordyce DE,Clark VJ,Paylor R,et al.Enhancement of hippocampally-mediated learning and protein kinase Cactivity by oxiracetam in learning-impaired DBA/2 mice[J].Brain Res,1995,672(1-2):170-176.
[4]Mondadori C,Petschke F,Hausler A.The effects of nootropics on memory:new aspects for basic research[J].Pharmacopsychiatry,1989,22(Suppl2):102-106.
[5]Fagni L,Chavis P,Ango F,et al.Complex interactions between m Glu Rs,intracellular Ca2+stores and ion channels in neurons[J].Trends Neurosci,2000,23(2):80-88.
[6]De Angelis L,Furlan C.The effects of ascorbic acid and oxiracetam on scopolamine-induced amnesia in a habituation test in aged mice[J].Neurobiol Learn Mem,1995,64(2):119-124.
[7]Nakamoto Y,Shiotani T,Watabe S,et al.Nootropic nefiracetam inhibits proconvulsant action of peripheral-type benzodiazepines in epileptic mutant EL mice[J].Ann N Y Acad Sci,2004,1025:135-139.
[8]Hlinák Z,KrejcíI.Oxiracetam prevents the MK-801 induced amnesia for the elevated plus-maze in mice[J].Behav Brain Res,2000,117(1-2):147-151.
[9]Smith AM,Wehner JM.Aniracetam improves contextual fear conditioning and increases hippocampal gamma-PKC activation in DBA/2J mice[J].Hippocampus,2002,12(1):76-85.
[10]Hlinák Z,KrejcíI.Oxiracetam prevented the scopolamine but not the diazepam induced memory deficits in mice[J].Behav Brain Res,2002,133(2):395-399.
[11]Mondadori C,Ducret T,Petschke F.Blockade of the nootropic action of piracetam-like nootropics by adrenalectomy:an effect of dosage[J]?Behav Brain Res,1989,34(1-2):155-158.
[12]Rozzini R,Zanetti O,Bianchetti A.Treatment of cognitive impairment secondary to degenerative dementia.Effectiveness of oxiracetam therapy[J].Acta Neurol(Napoli),1993,15(1):44-52.
[13]赵桂萍,王荫华,赵玉宾,等.国产奥拉西坦治疗痴呆的临床评价[J].中国临床药理学杂志,1997,13(1):17-21.
[14]李建伟,杨东军,陈旭义,等.奥拉西坦对颅脑损伤大鼠的保护作用[J].中国应用生理学杂志,2013,29(4):298-300.
[15]朱继.奥拉西坦治疗轻中型脑伤的临床研究[J].第三军医大学学报,2006,28(10):1124-1125.
[16]刘中元.奥拉西坦治疗颅脑损伤临床效果观察[J].海峡药学,2012,24(2):97-98.
[17]于万水.奥拉西坦改善中型颅脑损伤患者神经功能缺失、记忆与智能障碍的疗效分析[J].中国伤残医学,2013,21(2):92-93.
[18]Kometani M,Okada M,Takemori E,et al.Effect of oxiracetam on cerebrovascular impairment in rats[J].Arzneimittelforschung,1991,41(7):684-689.
[19]Wang C,Li F,Guan Y,et al.Bone marrow stromal cells combined with oxiracetam influences the expression of B-cell lymphoma 2 in rats with ischemic stroke[J].J Stroke Cerebrovasc Dis,2014,23(10):2591-2597.
[20]丁绪平,马风杰,张学敏,等.奥拉西坦对脑出血大鼠的脑保护作用及对Caspase-3表达的影响[J].现代中西医结合杂志,2013,22(4):363-374.
[21]姚恺,邬军锋,杨晓波,等.神经保护剂治疗急性脑梗死患者的疗效及安全性[J].中国老年学杂志,2012,32(19):4137-4139.
[22]张亚兰.奥拉西坦与灯盏花素联合治疗急性脑梗死疗效分析[J].基层医学论坛,2015,19(27):3770-3772.
[23]刘军武.大面积脑梗塞予以奥拉西坦联合依达拉奉的临床疗效分析[J].黑龙江医学,2015,39(11):1274-1275.
[24]赵金凤.高血压脑出血患者应用奥拉西坦疗效观察[J].中国实用神经疾病杂志,2012,15(4):88-89.
[25]李繁云,李繁丽.高血压脑出血患者应用奥拉西坦效果分析[J].世界最新医学信息文摘,2015,15(61):106-110.