柄叶香茶菜化学成分的研究
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摘要
目的研究柄叶香茶菜Rabdosiaphyllopoda的化学成分。方法采用硅胶、凝胶柱色谱、制备型HPLC等方法进行分离纯化,通过理化性质、光谱数据鉴定化合物结构。结果从柄叶香茶菜中分离得到了14个化合物,分别鉴定为(Z)-1,1′-biindenyliden(1)、β,β-carotene(2)、大根香叶烯B(3)、2α,3α,24-三羟基-12-烯-28-齐墩果酸(4)、阿魏酸二十六烷酯(5)、过氧化麦角甾醇(6)、熊果酸(7)、α-香树脂酸乙酸酯(8)、obtusalin(9)、桦木酸(10)、2α,3α,19α-三羟基-12-烯-28-乌苏酸(11)、2α,3α-二羟基-12-烯-28-齐墩果酸(12)、2α-羟基乌苏酸(13)、叶黄素(14)。结论 14个化合物均首次从该植物中分离得到,其中化合物1、3、6、9、14首次从香茶菜属植物中分离得到。
Objective To investigate the chemical constituents of Rabdosia phyllopoda. Methods The chemical constituents were isolated and purified by chromatography with silica gel, Sephadex LH-20 and by semi-preparative HPLC, and their structures were identified by analysis of spectroscopic evidences and physicochemical properties. Results A total of 14 constituents were isolated from R. phyllopoda and elucidated as(Z)-1,1′-biindenyliden(1), β,β-carotene(2), germacrene B(3), 2α,3α,24-trihydrxyolean-12-en-28 oic acid(4), ferulic acid hexacosanyl ester(5), ergosterol peroxide(6), ursolic acid(7), α-amyrin acetate(8), obtusalin(9),betulinic acid(10), 2α,3α,19α-trihydroxy-12-en-28-urs acid(11), 2α,3α-dihydroxyl-12-ene-28 oic acid(12), 2α-hydroxyursolic acid(13), and lutein(14). Conclusion The 14 compounds are isolated from this plant for first time, and compound 1, 3, 6, 9, 14 are isolated from the plants of R. phyllopoda for the first time.
Objective To investigate the chemical constituents of Rabdosia phyllopoda. Methods The chemical constituents were isolated and purified by chromatography with silica gel, Sephadex LH-20 and by semi-preparative HPLC, and their structures were identified by analysis of spectroscopic evidences and physicochemical properties. Results A total of 14 constituents were isolated from R. phyllopoda and elucidated as(Z)-1,1′-biindenyliden(1), β,β-carotene(2), germacrene B(3), 2α,3α,24-trihydrxyolean-12-en-28 oic acid(4), ferulic acid hexacosanyl ester(5), ergosterol peroxide(6), ursolic acid(7), α-amyrin acetate(8), obtusalin(9),betulinic acid(10), 2α,3α,19α-trihydroxy-12-en-28-urs acid(11), 2α,3α-dihydroxyl-12-ene-28 oic acid(12), 2α-hydroxyursolic acid(13), and lutein(14). Conclusion The 14 compounds are isolated from this plant for first time, and compound 1, 3, 6, 9, 14 are isolated from the plants of R. phyllopoda for the first time.
引文
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[15]戴畅,刘屏,刘超,等.藓类植物回心草化学成分研究Ⅱ[J].中国中药杂志,2006,31(13):1080-1082.
[16]Otaka J,Seo S,Nishimura M.Lutein,a natural carotenoid,inducesα-1,3-glucan accumulation on the cell wall surface of fungal plant pathogens[J].Molecules,2016,21(8):980-990.
[2]中国科学院中国植物志编辑委员会.中国植物志(第66卷)[M].北京:科学出版社,1990.
[3]杨一兵,朱大元.柄叶香茶菜及其甲素体外抑菌的研究[J].现代应用药学,1995,12(2):25-26.
[4]王珺,高羽,张朝凤,等.对叶百部中的非生物碱类成分[J].药学与临床研究,2012,20(3):193-195.
[5]Palermo J A,Eduarw G,et al.Carotenoids from three red algae of the Corallinaceae[J].Phyrochemisrry,1991,30(9):2983-2986.
[6]樊晓娜,林生,朱承根,等.小花异裂菊中的萜类成分及其活性[J].中国中药杂志,2010,35(3):315-322.
[7]刘普段宏泉潘勤等.委陵菜三萜成分研究[J].中国中药杂志,2006,31(22):1875-1879.
[8]王国艳,林平川,王峥涛,等.紫菀酚类化学成分的研究[J].中国中药杂志,2003,28(10):946-948.
[9]巢剑非,殷志琦,叶文才,等.构树的化学成分研究[J].中国中药杂志,2006,31(13):1078-1080.
[10]黄泽豪,秦路平.华中五味子藤茎的化学成分研究[J].中草药,2016,47(19):3374-3378.
[11]Niaz A.Brine shrimp cytotoxicity of crude methanol extract and antispasmodic activity ofα-amyrin acetate from Tylophora hirsuta Wall[J].BMC Compl Alter Med,2013,13(6):135-142.
[12]刘莹,李喜凤,刘艾林,等.细皱香薷叶的化学成分研究[J].中草药,2009,40(9):1356-1359.
[13]杨维力,田军,彭树林,等.南川鹭鸶草的化学成分[J].药学学报,2001,36(8):590-594.
[14]牛宝静,马柱坤,廖志新,等.异叶青兰的化学成分研究[J].中草药,2013,44(2):147-152.
[15]戴畅,刘屏,刘超,等.藓类植物回心草化学成分研究Ⅱ[J].中国中药杂志,2006,31(13):1080-1082.
[16]Otaka J,Seo S,Nishimura M.Lutein,a natural carotenoid,inducesα-1,3-glucan accumulation on the cell wall surface of fungal plant pathogens[J].Molecules,2016,21(8):980-990.