可切除非小细胞肺癌患者ABO血型与预后相关性
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摘要
[目的]探讨可切除的非小细胞肺癌ABO血型与预后之间的相关性。[方法]回顾性分析2009年1月至2010年12月行肺癌根治术的非小细胞肺癌患者274例,收集包括血型在内的临床资料并进行生存随访。比较各血型之间5年生存率,并采用Cox比例风险模型进行单因素及多因素生存分析。[结果] O型患者的5年生存率分别为70.1%,A型为67.2%,B型为39.7%,AB型为56%。与非O型患者相比,O型患者5年生存率更高(P=0.002)。多因素分析提示年龄、病理分期,病理分型以及血型为独立的预后因素。[结论] ABO血型与可切除的非小细胞肺癌预后具有相关性,可作为一种独立的预后因素。
[Objective] To explore the association between the ABO blood types and the prognosis in patients with resectabled non-small cell lung cancer(NSCLC). [Methods] Clinical data of 274 patients with resectable NSCLC admitted from January 2009 to December 2010 were analyzed retrospectively. The five-year overall survival rates(OS) were compared among patients with various blood types. A Cox proportional hazard model was used for the univariate and multivariate survival analyses. [Results] The 5-year overall survival rates were 70.1% for blood O group,67.2%for blood A group,39.7% for blood B group and 56% for blood AB group,respectively. The OS rate of patients with blood O type was higher than those of non-O type patients(P=0.002). Multivariate analysis showed that ABO blood types,age,pathological type and stage were independent prognostic factors for patients with resectable NSCLC. [Conclusion] The ABO blood group is related to the prognosis of patients with resectable NSCLC.
[Objective] To explore the association between the ABO blood types and the prognosis in patients with resectabled non-small cell lung cancer(NSCLC). [Methods] Clinical data of 274 patients with resectable NSCLC admitted from January 2009 to December 2010 were analyzed retrospectively. The five-year overall survival rates(OS) were compared among patients with various blood types. A Cox proportional hazard model was used for the univariate and multivariate survival analyses. [Results] The 5-year overall survival rates were 70.1% for blood O group,67.2%for blood A group,39.7% for blood B group and 56% for blood AB group,respectively. The OS rate of patients with blood O type was higher than those of non-O type patients(P=0.002). Multivariate analysis showed that ABO blood types,age,pathological type and stage were independent prognostic factors for patients with resectable NSCLC. [Conclusion] The ABO blood group is related to the prognosis of patients with resectable NSCLC.
引文
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[2]He M,Wolpin B,Rexrode K,et al.ABO blood group and risk of coronary heart disease in two prospective cohort studies[J].Arterioscler Thromb Vasc Biol,2012,32(9):2314-2320.
[3]Williams FM,Carter AM,Hysi PG,et al.Ischemic stroke is associated with the ABO locus:the EuroCLOT study[J]Ann Neurol,2013,73(1):16-31.
[4]Wang Z,Liu L,Ji J,et al.ABO blood group system and gastric cancer:a case control study and meta-analysis[J]Int J Mol Sci,2012,13(10):13308-13321.
[5]Risch HA,Lu L,Wang J,et al.ABO blood group and risk of pancreatic cancer:a study in Shanghai and meta-analysis[J].Am J Epidemiol,2013,177(12):1326-1337.
[6]Joh HK,Cho E,Choueiri TK.ABO blood group and risk of renal cell cancer[J].Cancer Epidemiol,2012,36(6):528-532.
[7]Mao Y,Yang W,Qi Q,et al.Blood groups A and AB are associated with increased gastric cancer risk:evidence from a large genetic study and systematic review[J].BMCCancer,2019,19(1):164.
[8]Liu F,Li C,Zhu J,et al.ABO blood type and risk of hepatocellular carcinoma:a meta-analysis[J].Expert Rev Gastroenterol Hepatol,2018,12(9):927-933.
[9]Amundadottir L,Kraft P,Stolzenberg-Solomon RZ,et al.Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer[J].Nat Genet,2009,41(9):986-990.
[10]Gates MA,Wolpin BM,Cramer DW,et al.ABO blood type and incidence of epithelial ovarian cancer[J].Int J Cancer,2011,128(2):482-486.
[11]Jian Qin,San-gang Wu,Jia-Yuan Sun,et al.Effect of blood type on survival of Chinese patients with esophageal squamous cell carcinoma[J].OncoTargets and Therapy,2015,8:947-953.
[12]Fukumoto K,Taniguchi T,Usami N,et al.The ABO blood group is an independent prognostic factor in patients with resected non-small cell lung cancer[J].J Epidemiol,2015,25(2):110-116.
[13]Coussens LM,Werb Z.Inflammation and cancer[J].Nature,2002,420(6917):860-867.
[14]Suadicani P,Hein HO,Gyntelberg F.ABO phenotypes and inflammation-related predictors of lung cancer mortality:the Copenhagen Male Study-a 16-year follow-up[J].Eur Respir J,2007,30(1):13-20.