五子衍宗丸对生殖系统的保护作用及其临床研究进展
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摘要
五子衍宗丸由枸杞子、菟丝子、五味子、覆盆子、车前子5味药组成,具有填精补髓、补益肾气的功能,是治疗男性生殖系统疾病的常用药方。五子衍宗丸能够增强睾丸生精功能,调节下丘脑-垂体-性腺轴功能,还有抗衰老、抗氧自由基、增强免疫等多种作用,现对其在生殖系统保护作用及其临床研究进展做一综述。
Wuzi Yanzong Pill is composed of five medical herbs,Fructus lycii,Semen cuscutae,Fructus schisandrae chinensis,Fructus rubi and Semen plantaginis.Wuzi Yanzong Pill is a kind of frequently-used prescription to treat diseases of male reproductive system because of its function of benei ting essence and marrow and replenishing kidney qi.Wuzi Yanzong Pill can enhance spermatogenesis of testis,regulate the hypothalamic-pituitary-gonadal axis function,help anti-aging,antioxidant free radicals and enhance immunity,etc.Its protective effect on the reproductive system and its clinical research progress will be reviewed in this paper.
Wuzi Yanzong Pill is composed of five medical herbs,Fructus lycii,Semen cuscutae,Fructus schisandrae chinensis,Fructus rubi and Semen plantaginis.Wuzi Yanzong Pill is a kind of frequently-used prescription to treat diseases of male reproductive system because of its function of benei ting essence and marrow and replenishing kidney qi.Wuzi Yanzong Pill can enhance spermatogenesis of testis,regulate the hypothalamic-pituitary-gonadal axis function,help anti-aging,antioxidant free radicals and enhance immunity,etc.Its protective effect on the reproductive system and its clinical research progress will be reviewed in this paper.
引文
[1]孔令青,李鸣镝.中医方剂“五子衍宗丸”组方的历史源流.中国中医基础医学杂志,2009,15(1):67-68
[2]李育浩,吴清和,李茹柳,等.五子衍宗丸药理研究I.对生殖系统的影响.中药药理与临床,1992,8(3):4-6
[3]张树成,贺斌,王尚明,等.五子衍宗丸和金匮肾气丸对动物生精功能影响的比较研究.中国计划生育学杂志,2009,17(7):401-404
[4]王秋萍,王桐生,龙子江,等.五子衍宗丸对少弱精症模型大鼠精子质量及睾丸组织的影响.中成药,2011,33(10):1796-1797
[5]郝兴霞,杨敬英,龚道元.活性氧与男性不育相关研究进展.医学综述,2011,17(18):2726-2729
[6]刘保兴,张圣强,谢春雨,等.五子衍宗丸含药血清对活性氧致大鼠精子活力下降的保护作用.北京中医药大学学报(中医临床版),2010,17(1):13-15
[7]周伟强.五子衍宗软胶囊治疗肾虚精亏证男性少精、弱精不育症研究分析.中医临床研究,2011,3(20):83-84
[8]李轩,白勇,钟树怀,等.五子衍宗丸对不育患者精浆果糖影响的临床研究.内蒙古中医药,2009,12(12):1-2
[9]李轩,白勇,钟树怀,等.五子衍宗丸对不育患者附睾功能和精子活力的影响.光明中医,2009,24(7):1222-1223
[10]张圣强,刘保兴,王鑫,等.五子衍宗丸含药血清对大鼠睾丸支持细胞分泌产物的影响.中华中医药杂志,2013,28(3):631-634
[11]张圣强,刘保兴,王鑫,等.五子衍宗丸含药血清对大鼠睾丸支持细胞活力的影响.北京中医药大学学报,2013,36(3):174-177
[12]殷金龙,徐渊,吴斌.五子衍宗复方对睾丸支持细胞氧化应激损伤和细胞凋亡的影响.中华男科学杂志,2013,19(3):257-261
[13]王学美,谢竹藩,刘庚信,等.五子衍宗液对雄性大鼠下丘脑单胺类递质、性激素和生育能力的影响.中国中西医结合杂志,1993,13(6):349-351
[14]王学美,谢竹藩,彭先忠,等.五子衍宗液延缓衰老的临床研究.中国中西医结合杂志,1992,12(1):23-25
[15]孙志伟,李玉洲,张长城.五子衍宗丸药理作用及其临床研究进展.亚太传统医药,2010,6(12):179-181
[16]孙青凤.五子衍宗丸加减治疗排卵障碍性不孕临床研究.吉林中医药,2012,32(12):1243-1244
[17]庞玉琴.五子衍宗丸治疗子宫发育不良的不孕症100例.河南中医药学刊,1995,10(6):43-44
[18]陈阳,付正英,张引国,等.五子衍宗丸对Gn RHa控制性超促排卵小鼠着床期S100A11基因的调控.中医药导报,2014,20(8):14-17
[19]李丽蓉,张小方,潘胜军.五子衍宗丸联合西药治疗无排卵型不孕症的疗效观察.中医临床研究,2014,6(26):4-5
[20]Nils Hovdenak,Kjell Haram.Influence of mineral and vitamin supplements on pregnancy outcome.European Journal of Obstetrics&Gynecology and Reproductive Biology,2012,164:127-132
[21]Mustafa A Salih,Dr Med Sci,FRCPCH,et al.Epidemiology,prenatal management,and prevention of neural tube defects.Saudi Med J,2014,35(1):15-28
[22]Carmen Maestro-de-las-Casas,Juliana P,erez-Miguelsanz,Yamila L,opez-Gordillo,et al.Maternal folic acid-deficient diet causes congenital malformations in the mouse eye.Birth Defects Research,2013,97:587-596
[23]许凯霞,王永辉,杨向竹,等.补肾方剂对胎鼠DNA、RNA影响的实验研究.新中医,2013,45(2):137-138
[24]许凯霞,王永辉,杨向竹,等.补肾方剂对子代小鼠非特异性免疫功能的影响.中国实验方剂学杂志,2012,18(9):161-164
[25]樊慧杰,柴智,解军,等.五子衍宗丸对ATRA诱导的神经管畸形防治作用的初探.中成药,2014,36(5):1054-1056
[26]樊慧杰,李艳彦,柴智,等.五子衍宗丸对NTDs胎鼠神经管细胞凋亡的影响.中国实验方剂学杂志,2014,20(9):143-146
[27]李娌,王学美.五子衍宗方的临床运用及现代研究.中国实验方剂学杂志,2007,13(4):63-67
[28]Chen M L,Tsai S H,Ip S P,et al.Long-term treatment with a‘Yanginvigorating’Chinese herbal formula,Wu-Zi-Yan-ZongWan,reduces mortality and liver oxidative damage in chronic alcohol-intoxicated rats.Rejuvenation Research,2010,13(4):459-467
[29]Chen M L,Ip S P,Tsai S,et al.Biochemical mechanism of WuZi-Yan-Zong-Wan,a traditional Chinese herbal formula,against alcohol-induced oxidative damage in CYP2E1 c DNA-transfected Hep G2(E47)cells.Journal of Ethnopharmacology,2010,128(1):116-122
[2]李育浩,吴清和,李茹柳,等.五子衍宗丸药理研究I.对生殖系统的影响.中药药理与临床,1992,8(3):4-6
[3]张树成,贺斌,王尚明,等.五子衍宗丸和金匮肾气丸对动物生精功能影响的比较研究.中国计划生育学杂志,2009,17(7):401-404
[4]王秋萍,王桐生,龙子江,等.五子衍宗丸对少弱精症模型大鼠精子质量及睾丸组织的影响.中成药,2011,33(10):1796-1797
[5]郝兴霞,杨敬英,龚道元.活性氧与男性不育相关研究进展.医学综述,2011,17(18):2726-2729
[6]刘保兴,张圣强,谢春雨,等.五子衍宗丸含药血清对活性氧致大鼠精子活力下降的保护作用.北京中医药大学学报(中医临床版),2010,17(1):13-15
[7]周伟强.五子衍宗软胶囊治疗肾虚精亏证男性少精、弱精不育症研究分析.中医临床研究,2011,3(20):83-84
[8]李轩,白勇,钟树怀,等.五子衍宗丸对不育患者精浆果糖影响的临床研究.内蒙古中医药,2009,12(12):1-2
[9]李轩,白勇,钟树怀,等.五子衍宗丸对不育患者附睾功能和精子活力的影响.光明中医,2009,24(7):1222-1223
[10]张圣强,刘保兴,王鑫,等.五子衍宗丸含药血清对大鼠睾丸支持细胞分泌产物的影响.中华中医药杂志,2013,28(3):631-634
[11]张圣强,刘保兴,王鑫,等.五子衍宗丸含药血清对大鼠睾丸支持细胞活力的影响.北京中医药大学学报,2013,36(3):174-177
[12]殷金龙,徐渊,吴斌.五子衍宗复方对睾丸支持细胞氧化应激损伤和细胞凋亡的影响.中华男科学杂志,2013,19(3):257-261
[13]王学美,谢竹藩,刘庚信,等.五子衍宗液对雄性大鼠下丘脑单胺类递质、性激素和生育能力的影响.中国中西医结合杂志,1993,13(6):349-351
[14]王学美,谢竹藩,彭先忠,等.五子衍宗液延缓衰老的临床研究.中国中西医结合杂志,1992,12(1):23-25
[15]孙志伟,李玉洲,张长城.五子衍宗丸药理作用及其临床研究进展.亚太传统医药,2010,6(12):179-181
[16]孙青凤.五子衍宗丸加减治疗排卵障碍性不孕临床研究.吉林中医药,2012,32(12):1243-1244
[17]庞玉琴.五子衍宗丸治疗子宫发育不良的不孕症100例.河南中医药学刊,1995,10(6):43-44
[18]陈阳,付正英,张引国,等.五子衍宗丸对Gn RHa控制性超促排卵小鼠着床期S100A11基因的调控.中医药导报,2014,20(8):14-17
[19]李丽蓉,张小方,潘胜军.五子衍宗丸联合西药治疗无排卵型不孕症的疗效观察.中医临床研究,2014,6(26):4-5
[20]Nils Hovdenak,Kjell Haram.Influence of mineral and vitamin supplements on pregnancy outcome.European Journal of Obstetrics&Gynecology and Reproductive Biology,2012,164:127-132
[21]Mustafa A Salih,Dr Med Sci,FRCPCH,et al.Epidemiology,prenatal management,and prevention of neural tube defects.Saudi Med J,2014,35(1):15-28
[22]Carmen Maestro-de-las-Casas,Juliana P,erez-Miguelsanz,Yamila L,opez-Gordillo,et al.Maternal folic acid-deficient diet causes congenital malformations in the mouse eye.Birth Defects Research,2013,97:587-596
[23]许凯霞,王永辉,杨向竹,等.补肾方剂对胎鼠DNA、RNA影响的实验研究.新中医,2013,45(2):137-138
[24]许凯霞,王永辉,杨向竹,等.补肾方剂对子代小鼠非特异性免疫功能的影响.中国实验方剂学杂志,2012,18(9):161-164
[25]樊慧杰,柴智,解军,等.五子衍宗丸对ATRA诱导的神经管畸形防治作用的初探.中成药,2014,36(5):1054-1056
[26]樊慧杰,李艳彦,柴智,等.五子衍宗丸对NTDs胎鼠神经管细胞凋亡的影响.中国实验方剂学杂志,2014,20(9):143-146
[27]李娌,王学美.五子衍宗方的临床运用及现代研究.中国实验方剂学杂志,2007,13(4):63-67
[28]Chen M L,Tsai S H,Ip S P,et al.Long-term treatment with a‘Yanginvigorating’Chinese herbal formula,Wu-Zi-Yan-ZongWan,reduces mortality and liver oxidative damage in chronic alcohol-intoxicated rats.Rejuvenation Research,2010,13(4):459-467
[29]Chen M L,Ip S P,Tsai S,et al.Biochemical mechanism of WuZi-Yan-Zong-Wan,a traditional Chinese herbal formula,against alcohol-induced oxidative damage in CYP2E1 c DNA-transfected Hep G2(E47)cells.Journal of Ethnopharmacology,2010,128(1):116-122