补肾益血生精法对特发性男性不育患者精子质量的影响
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摘要
目的:观察补肾益血生精法对特发性男性不育症精液质量的影响。方法:将98例患者随机分为对照组和治疗组,每组各49例。对照组服用五子衍宗软胶囊,治疗组以补肾益血生精为治疗大法,采用补肾益精方加减。观察两组患者治疗前后精液量、液化时间(Liquefaction time,LQF)、精子总数(Total sperm count,TMSC)、精子浓度(Sperm concentration,SC)、前向运动精子率(PR)和正常精子率(Sperm morphology,Normal forms,NF)。结果:治疗后两组患者精子总数、浓度、前向运动精子率、正常精子率均有提高,与治疗前比较,差异均有统计学意义(P<0.05)。治疗组精子质量在改善前向运动精子率和正常精子率方面比对照组改善更加明显,差异具有统计学意义(P<0 05)。结论:补肾益血生精法治疗特发性男性不育患者,可提高患者精子数量,改善精子质量。
Objective: To observe the influence of method of tonifying kidney and activating blood to produce essence on sperm quality of idiopathic male infertility. Methods: Ninety-eight patients with idiopathic male infertility were randomly divided into the control group and the treatment group,with 49 cases in each group. The ones in the control group were treated with Wuzi Yanzong Soft Capsule( WZYZSC),while the ones in the treatment group were treated with Modified Tonifying Kidney for Producing Essence Decoction. Then the two groups' semen volume,liquefaction time( LQF),total sperm count( TMSC),sperm concentration( SC) forward motility sperm rate( PR) and NF before and after the treatment were observed. Results: After the treatment,the total sperm count,concentration,forward motile sperm rate and normal sperm rate of the two groups were increased,compared with those before the treatment,and all the differences were statistically significant( P < 0. 05). The sperm quality in improving the rate of forward motile sperm and normal sperm in the treatment group was more obvious than that in the control group,and the difference was statistically significant( P < 0,05). Conclusion: Method of tonifying kidney and activating blood to produce essence has a remarkable clinical curative effect on sperm quality of idiopathic male infertility,can improve sperm number and its quality.
Objective: To observe the influence of method of tonifying kidney and activating blood to produce essence on sperm quality of idiopathic male infertility. Methods: Ninety-eight patients with idiopathic male infertility were randomly divided into the control group and the treatment group,with 49 cases in each group. The ones in the control group were treated with Wuzi Yanzong Soft Capsule( WZYZSC),while the ones in the treatment group were treated with Modified Tonifying Kidney for Producing Essence Decoction. Then the two groups' semen volume,liquefaction time( LQF),total sperm count( TMSC),sperm concentration( SC) forward motility sperm rate( PR) and NF before and after the treatment were observed. Results: After the treatment,the total sperm count,concentration,forward motile sperm rate and normal sperm rate of the two groups were increased,compared with those before the treatment,and all the differences were statistically significant( P < 0. 05). The sperm quality in improving the rate of forward motile sperm and normal sperm in the treatment group was more obvious than that in the control group,and the difference was statistically significant( P < 0,05). Conclusion: Method of tonifying kidney and activating blood to produce essence has a remarkable clinical curative effect on sperm quality of idiopathic male infertility,can improve sperm number and its quality.
引文
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[2]谷翊群.世界卫生组织人类精液检查与处理实验室手册[M].5版.北京:人民卫生出版社,2011:405.
[3]陈志强.中医临床诊治男科专病[M].3版.北京:人民卫生出版社,2013:331.
[4]王万荣,谭艳,谢胜.2013年欧洲泌尿科学会男性不育指南介绍[J].中国男科学杂志,2014,28(1):65-67.
[5]Jarow JP,Zirkin BR.The androgen microenvironment of the human testis and hormonal control of spermatogenesis[J].Ann N Y Acad Sci,2005,1061(1):208-220.
[6]Zirkin BR,Santulli R,Awoniyi CA,et al.Maintenance of advanced spermatogenic cells in the adult rat testis:quantitative relationship to testosterone concentration within the testis[J].Endocrinology,1989,124(3):3043-3049.
[7]Page ST.Physiologic role and regulation of intratesticular sex steroids[J].Curr Opin Endocrinol Diabetes Obes,2011,18(3):217-223.
[8]Katz DJ,Nabulsi O,Tal R,et al.Outcomes of clomiphene citrate treatment in young hypogonadal men[J].BJU Int,2012,110(4):573-578.
[9]Leder BZ,Rohrer JL,Rubin SD,et al.Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels[J].J Clin Endocrinol Metab,2004,89(3):1174-1180.
[10]Hotaling JM,Patel Z.Male endocrine dysfunction[J].Urol Clin North Am,2014,41(1):39-53.
[11]姚重华,宾彬.中医药治疗男性不育症研究进展[J].山东中医杂志,2006,25(3):212-215.
[12]Wang XZ,Uu SS,Sun JY,et al.Beta-cypermethrin impairs reproductive function in male mice by inducing oxidative stress[J].Theriogenology,2009,72(5):599-611.
[13]Potts RJ,Notarianni LJ,Jeferies TM.Seminal plasma reduces exogenous oxidative damage to human sperm,determined by the measurement of DNA strand breaks and lipid peroxidation[J].Mutation Research,2000,447(2):249.
[14]Pasqualotto FF.Sharma RK,Pasqualotto EB.Poor semen quality and ROS.TAC scores in patients with idiopathic infertility[J].Urol Int,2008,81(3):263-270.
[15]Kao SH,Chao HT,Chen HW,et al.Increase of oxidative stress in human sperm with lower motility[J].Fertil Steril,2008,89(5):1183-1190.
[16]Agarwal A,Prabakaran SA,Said TM.Prevention of Oxidative Stress Injury to Sperm[J].J Androl,2005,26(6):654-660.
[17]王晓峰,朱积川,邓春华.中国男科疾病诊疗指南[M].北京:人民卫生出版社,2013:28.
[18]Liang X.Effect of Wuwei Xiaodu Decoction on Seminal Plasma Hydrogen Peroxide(H202)of Leukocytospermia[J].China Journal of Chinese Medicine,2014,29(8):1191-1193.
[19]张敏建,郭军,陈磊,等.男性不育症中西医结合诊疗指南(试行版)[J].中国中西医结合杂志,2015,35(9):1034-1038.
[20]朱楣光,张越林,杨宪林,等.中医肾虚与下丘脑-垂体-睾丸轴关系的探讨[J].天津医药,1990,26(1):37-38.
[21]王三才.医便[M].北京:中国中医药出版社,2016:78.
[22]任豪,喻国华.喻文球治疗不育症的经验介绍[J].中华实用中西医杂志,2006,19(11):1273-1275.
[23]孙自学,陈建设.王琦教授治疗男性不育经验介绍[J].四川中医,2004,22(1):7-8.