清咽利喉汤联合金嗓散结丸治疗中重度急性喉炎的临床研究
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摘要
目的:观察清咽利喉汤联合金嗓散结丸治疗中重度急性喉炎的疗效及对患者T淋巴细胞亚群和血清炎性因子的影响。方法:将132例中重度急性喉炎患者按照随机数字表法分为治疗组和对照组,各66例,两组均予基础干预,在此基础上对照组予金嗓散结丸口服,治疗组在对照组基础上联合清咽利喉汤治疗。观察两组中医证候积分、症状消失时间、临床疗效,检测T淋巴细胞亚群水平和肿瘤坏死因子α(TNF-α)、白介素8(IL-8)、白介素4(IL-4)水平。结果:治疗后两组中医证候积分均显著低于治疗前(P<0.05),且治疗组显著低于对照组(P<0.05);治疗组喉鸣、呼吸困难、咳嗽、声音嘶哑消失时间显著短于对照组(P<0.05);治疗组总有效率为92.42%,显著高于对照组的78.79%(P<0.05);治疗后两组CD3~+、CD4~+、CD4~+/CD8~+水平均显著高于治疗前(P<0.05),且治疗组显著高于对照组(P<0.05),两组CD8~+水平均显著低于治疗前(P<0.05),且治疗组显著低于对照组(P<0.05);治疗后两组TNF-α、IL-8、IL-4水平均显著低于治疗前(P<0.05),且治疗组均显著低于对照组(P<0.05)。结论:清咽利喉汤联合金嗓散结丸可有效改善中重度急性喉炎患者T淋巴细胞亚群水平,降低血清炎性因子水平,提高临床疗效。
Objective: To observe the effect of Qingyan Lihou decoction combined with Jinsang Sanjie pills in the treatment of moderate and severe acute laryngitis, and the influence on T lymphocytes subsets and serum inflammatory factor. Method: One hundred and thirty-two cases of moderate and severe acute laryngitis in our hospital were selected, and they were divided into observation group and control group according to random number table, sixty-six cases in each group. Both the two groups were given basic intervention, on the basis of this, the control group was given Jinsang Sanjie pills, and the observation group was given Qingyan Lihou decoction on the basis of the observation group. The symptom scores, symptom disappearance time and clinical efficacy of the two groups were observed, and the levels of T lymphocyte subsets, tumor necrosis factor-α(TNF-α), interleukin-8(IL-8) and interleukin-4(IL-4) were detected. Results: After treatment, TCM syndrome scores of the two groups were significantly lower than those before treatment(P<0.05), and the observation group was significantly lower than that of the control group(P<0.05); the disappearance time of laryngeal voice, dyspnea,cough and hoarseness in the observation group was significantly lower than that in the control group(P<0.05);the total effective rate of the observation group was 92.42%, which was significantly higher than that of the control group 78.79%(P<0.05); the levels of CD3~+, CD4~+and CD4~+/CD8~+in the two groups after treatment were significantly higher than those before treatment(P<0.05), and the observation group was significantly higher than the control group(P<0.05); the level of CD8~+in the two groups after treatment was significantly lower than that before treatment(P<0.05), and the observation group was significantly lower than the control group(P<0.05); after treatment, the levels of TNF-α, IL-8 and IL-4 in the two groups were significantly lower than those before treatment(P<0.05), and the observation group was significantly lower than that of the control group(P <0.05).Conclusion: Qingyan Lihou decoction combined with Jinsang Sanjie pills can effectively improve T lymphocyte subsets level of moderate and severe acute laryngitis patients, reduce serum levels of inflammatory factors and improve clinical curative effect.
Objective: To observe the effect of Qingyan Lihou decoction combined with Jinsang Sanjie pills in the treatment of moderate and severe acute laryngitis, and the influence on T lymphocytes subsets and serum inflammatory factor. Method: One hundred and thirty-two cases of moderate and severe acute laryngitis in our hospital were selected, and they were divided into observation group and control group according to random number table, sixty-six cases in each group. Both the two groups were given basic intervention, on the basis of this, the control group was given Jinsang Sanjie pills, and the observation group was given Qingyan Lihou decoction on the basis of the observation group. The symptom scores, symptom disappearance time and clinical efficacy of the two groups were observed, and the levels of T lymphocyte subsets, tumor necrosis factor-α(TNF-α), interleukin-8(IL-8) and interleukin-4(IL-4) were detected. Results: After treatment, TCM syndrome scores of the two groups were significantly lower than those before treatment(P<0.05), and the observation group was significantly lower than that of the control group(P<0.05); the disappearance time of laryngeal voice, dyspnea,cough and hoarseness in the observation group was significantly lower than that in the control group(P<0.05);the total effective rate of the observation group was 92.42%, which was significantly higher than that of the control group 78.79%(P<0.05); the levels of CD3~+, CD4~+and CD4~+/CD8~+in the two groups after treatment were significantly higher than those before treatment(P<0.05), and the observation group was significantly higher than the control group(P<0.05); the level of CD8~+in the two groups after treatment was significantly lower than that before treatment(P<0.05), and the observation group was significantly lower than the control group(P<0.05); after treatment, the levels of TNF-α, IL-8 and IL-4 in the two groups were significantly lower than those before treatment(P<0.05), and the observation group was significantly lower than that of the control group(P <0.05).Conclusion: Qingyan Lihou decoction combined with Jinsang Sanjie pills can effectively improve T lymphocyte subsets level of moderate and severe acute laryngitis patients, reduce serum levels of inflammatory factors and improve clinical curative effect.
引文
[1]田霜.自拟滋阴祛风汤配合西药治疗慢性咽炎106例[J].广西中医药,2010,33(4):15-16.
[2]张磊.氧气驱动雾化吸入布地奈德治疗急性喉炎的疗效研究[J].海南医学院学报,2016,22(2):206-208.
[3]张志强.清咽利喉汤调治慢性咽喉炎52例分析[J].内蒙古中医药,2010,29(21):47.
[4]刘建功,赵晓宇,裴文兴,等.中西医结合治疗慢性咽炎的疗效评测[J].中国药物与临床,2017,17(5):724-725.
[5]赖广智.清喉利咽汤加减治疗急性咽喉炎50例[J].湖北中医杂志,2009,31(10):55.
[6]田勇泉.耳鼻咽喉头颈外科学[M].北京:人民卫生出版社,2013,82(24):1700-1702.
[7]阮岩.中医耳鼻咽喉科学[M].北京:人民卫生出版社,2012:156-157.
[8]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994.
[9]柴晓荣.清咽利喉茶治疗慢性咽喉炎的疗效观察[J].临床耳鼻咽喉头颈外科杂志,2011,25(7):324-325.
[10]刘辉辉,张文清,董丽红.雾化吸入布地奈德混悬液治疗小儿急性喉炎的效果评价[J].江西医药,2017,52(2):155-157.
[11]金杨君,金朝阳,金银芝.中西结合治疗反流性咽喉炎126例的临床疗效[J].中国临床药理学杂志,2015,31(7):498-500.
[12]李晓娜,李玉杰,黄炜,等.布地奈德对小儿感染性喉炎的疗效及IL-4、IFN-γ和IgE水平的影响[J].中国妇幼保健,2015,30(30):5194-5196.
[13]陈忆,黄克强.银翘散加减治疗急性咽喉炎疗效观察[J].山西中医,2015,31(1):38.
[14]赵慧.布地奈德与地塞米松治疗儿童急性喉炎疗效及其对免疫功能影响比较分析[J].中国实用儿科杂志,2016,31(3):224-226.
[15]李颖,付双莉,僧东杰.小儿喉炎综合免疫状态及痰液炎性指标的变化研究[J].医药论坛杂志,2017,38(5):120-122.
[16]钟丽花,李欣,王亚洲.小儿喉炎患者T淋巴细胞亚群及痰液相关炎症细胞因子的变化[J].中国妇幼保健,2017,32(6):1202-1204.
[17]周晓利.金嗓开音丸与金嗓散结丸联合治疗声带小结疗效观察[J].中国伤残医学,2015,24(18):110-111.
[18]王丽华,郭裕,胡蓉,等.夏枯草开音合剂治疗慢喉喑多中心临床规范化研究[J].中国中西医结合耳鼻咽喉科杂志,2016,24(4):298-301..
[19]张驰,杜锦朵,冉程.疏肝祛瘀化痰汤配合西药治疗慢性咽喉炎疗效观察[J].陕西中医,2015,36(3):316-317.
[20]方春凤.自拟清咽利喉汤治疗急性咽喉炎30例疗效观察[J].云南中医中药杂志,2017,38(3):49-50.
[2]张磊.氧气驱动雾化吸入布地奈德治疗急性喉炎的疗效研究[J].海南医学院学报,2016,22(2):206-208.
[3]张志强.清咽利喉汤调治慢性咽喉炎52例分析[J].内蒙古中医药,2010,29(21):47.
[4]刘建功,赵晓宇,裴文兴,等.中西医结合治疗慢性咽炎的疗效评测[J].中国药物与临床,2017,17(5):724-725.
[5]赖广智.清喉利咽汤加减治疗急性咽喉炎50例[J].湖北中医杂志,2009,31(10):55.
[6]田勇泉.耳鼻咽喉头颈外科学[M].北京:人民卫生出版社,2013,82(24):1700-1702.
[7]阮岩.中医耳鼻咽喉科学[M].北京:人民卫生出版社,2012:156-157.
[8]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994.
[9]柴晓荣.清咽利喉茶治疗慢性咽喉炎的疗效观察[J].临床耳鼻咽喉头颈外科杂志,2011,25(7):324-325.
[10]刘辉辉,张文清,董丽红.雾化吸入布地奈德混悬液治疗小儿急性喉炎的效果评价[J].江西医药,2017,52(2):155-157.
[11]金杨君,金朝阳,金银芝.中西结合治疗反流性咽喉炎126例的临床疗效[J].中国临床药理学杂志,2015,31(7):498-500.
[12]李晓娜,李玉杰,黄炜,等.布地奈德对小儿感染性喉炎的疗效及IL-4、IFN-γ和IgE水平的影响[J].中国妇幼保健,2015,30(30):5194-5196.
[13]陈忆,黄克强.银翘散加减治疗急性咽喉炎疗效观察[J].山西中医,2015,31(1):38.
[14]赵慧.布地奈德与地塞米松治疗儿童急性喉炎疗效及其对免疫功能影响比较分析[J].中国实用儿科杂志,2016,31(3):224-226.
[15]李颖,付双莉,僧东杰.小儿喉炎综合免疫状态及痰液炎性指标的变化研究[J].医药论坛杂志,2017,38(5):120-122.
[16]钟丽花,李欣,王亚洲.小儿喉炎患者T淋巴细胞亚群及痰液相关炎症细胞因子的变化[J].中国妇幼保健,2017,32(6):1202-1204.
[17]周晓利.金嗓开音丸与金嗓散结丸联合治疗声带小结疗效观察[J].中国伤残医学,2015,24(18):110-111.
[18]王丽华,郭裕,胡蓉,等.夏枯草开音合剂治疗慢喉喑多中心临床规范化研究[J].中国中西医结合耳鼻咽喉科杂志,2016,24(4):298-301..
[19]张驰,杜锦朵,冉程.疏肝祛瘀化痰汤配合西药治疗慢性咽喉炎疗效观察[J].陕西中医,2015,36(3):316-317.
[20]方春凤.自拟清咽利喉汤治疗急性咽喉炎30例疗效观察[J].云南中医中药杂志,2017,38(3):49-50.