早产SGA产后24h内血清Ghrelin、IGF-1、INS水平与胎龄及体格发育指标相关性分析
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摘要
目的研究早产小于胎龄儿(SGA)产后24 h血清中Ghrelin、胰岛素样生长因子(IGF-1)、胰岛素(INS)水平与胎龄以及发育指标的相关性。方法收集我院产科2006-10~2013-10间的出生的早产SGA500例,按照出生体重将病例分为三组:1000~1500 g的为A组(121例),1500~2000 g的为B组(245例),2000~2500 g的为C组(134例),所有的患者分别于开奶前抽取静脉血2~3 m L,离心去血清后分别测定Ghrelin、IGF-1、INS水平,研究与胎龄以及体格发育的相关性。结果早产SGA产后24 h内血清Ghrelin随着体重的增加而逐渐降低,并且经过统计学检验三组之间的差异具有统计学意义(P<0.05),IGF-1、INS水平随着体重的增加逐渐升高,并且两种因素在三组之间的差异均具有统计学意义(P<0.05);利用Pearson相关性分析显示,早产SGA产后24 h内血清Ghrelin水平与胎龄、出生体质量、身长、BMI呈负相关,而与出生头围相关性不明显;IGF-1水平与胎龄、出生体质量、身长、头围、BMI呈正相关;INS水平与胎龄、出生体质量、身长、头围、BMI呈正相关。结论早产SGA产后24 h内血清Ghrelin、IGF-1、INS水平与胎龄及体格发育指标之间具有明显的相关性,同时可以将Ghrelin、IGF-1、INS水平作为婴儿体格发育的有效的指标。
Objective To study the relevance of the serum Ghrelin,IGF- 1 and INS level with gestational age and growth indicators24 h after premature SGA. Methods Collecting 500 cases with SGA infants born from October,2006 to October,2013,and dividing them into three groups according to the birth weight,1000 ~ 1500 g for group A( 121 cases),1500 ~ 2000 g for group B( 245 cases),2000 ~2500 g for group C( 134 cases). All patients were extracted venous blood 2 ~ 3 m L respectively before having breast- feed,Ghrelin,IGF- 1 and INS level were determined after centrifugal to serum,and the correlation of gestational age and physical development was researched. Results Serum Ghrelin reduced gradually with the increase of body weight 24 h after premature SGA,and the difference among three groups was statistically tested,with statistical significance( P < 0. 05). IGF- 1,INS level increased with body weight,and the differences between the two factors in three groups were statistically significant( P < 0. 05); Pearson correlation analysis showed that within24 h after premature SGA group,serum levels of Ghrelin was negatively correlated with gestational age,birth body mass,body length and BMI,while there was no obvious correlation with birth head circumference; IGF- 1 level and gestational age,birth body mass,body length,head circumference and BMI were positively correlated with INS. Conclusion The premature SGA infants within 24 h after birth and serum levels of Ghrelin,IGF 1,INS gestational age and physical development index have obvious correlation,at the same time Ghrelin,IGF- 1 and INS level can be regarded as the effective indicators of infant physical development.
Objective To study the relevance of the serum Ghrelin,IGF- 1 and INS level with gestational age and growth indicators24 h after premature SGA. Methods Collecting 500 cases with SGA infants born from October,2006 to October,2013,and dividing them into three groups according to the birth weight,1000 ~ 1500 g for group A( 121 cases),1500 ~ 2000 g for group B( 245 cases),2000 ~2500 g for group C( 134 cases). All patients were extracted venous blood 2 ~ 3 m L respectively before having breast- feed,Ghrelin,IGF- 1 and INS level were determined after centrifugal to serum,and the correlation of gestational age and physical development was researched. Results Serum Ghrelin reduced gradually with the increase of body weight 24 h after premature SGA,and the difference among three groups was statistically tested,with statistical significance( P < 0. 05). IGF- 1,INS level increased with body weight,and the differences between the two factors in three groups were statistically significant( P < 0. 05); Pearson correlation analysis showed that within24 h after premature SGA group,serum levels of Ghrelin was negatively correlated with gestational age,birth body mass,body length and BMI,while there was no obvious correlation with birth head circumference; IGF- 1 level and gestational age,birth body mass,body length,head circumference and BMI were positively correlated with INS. Conclusion The premature SGA infants within 24 h after birth and serum levels of Ghrelin,IGF 1,INS gestational age and physical development index have obvious correlation,at the same time Ghrelin,IGF- 1 and INS level can be regarded as the effective indicators of infant physical development.
引文
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[2]董卫华,刘一凡,冯小兰.早产儿与足月儿在1岁以内体格发育比较[J].中国妇幼保健,2011,2(18):96~98.
[3]Nanio Y,Adachi H,Hirai Y,et al.Factors associated withplasma ghrelin level in Japanese general population[J].Clin Endocrinol(Oxf),2011,6(43):74~76.
[4]张琼,张知新.胰岛素样生长因子系统对生长迟缓的影响机制[J].中国医学科学院学报,2011,7(1):8~10.
[5]陆昊,王春,林勇.慢性阻塞性肺疾病急性加重期患者血浆炎症因子与生长激素释放肽水平的变化[J].江苏医药,2011,78(24):6~9.
[6]井丽娟,尹建英.不同胎龄及体重新生儿血Ghrelin、胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3、胰岛素水平检测分析[J].中国妇幼保健,2011,7(26):74~77.
[7]井丽娟,尹建英.2~7岁小于胎龄儿血Ghrelin、胰岛素样生长因子-1和胰岛素样生长因子结合蛋白-3的水平及其意义[J].吉林大学学报(医学版),2011,84(4):597~600.
[8]宋娜娜,丁文惠,唐朝枢.Ghrelin与心力衰竭[J].中华老年多器官疾病杂志,2011,9(6):78~79.
[9]任路平,宋光耀.非酒精性脂肪肝疾病发生机制研究新进展[J].中国老年学杂志,2012,75(3):965~966.
[10]卢亚敏,宋光耀,李萍.不同脂肪酸饮食对糖耐量正常人群内脏脂肪素及其胰岛素抵抗的影响[J].中国糖尿病杂志,2012,4(1):9~11.