大溪地诺丽果浆的亚慢性经口毒性试验研究
摘要
<正>诺丽(Noli),又称海巴戟天(Morindacitrifolia L.),是原产于南太平洋岛屿的热带多年生阔叶灌木植物,在我国海南、西沙群岛和台湾也有分布。诺丽被当地居民用于治疗疾病的传统具有久远历史,是波利尼西亚人和库克人最主要的药用植物之一,主要用于抗感染和治疗慢性疾病~([1])。诺丽的果实具有较长的食用历史,富有多种营养成分和药用成分,包括环烯醚萜、蒽醌、木脂素、香豆素、三萜、甾醇、黄酮及其苷、苯醚类
引文
[1]Wang MY,West BJ,Jensen CJ,et al.Morinda citrifolia(Noni):a literature review and recent advances in Noni research[J].Acta Pharmacol Sin,2002,23(12):1127-1141.
[2]Pawlus AD,Kinghorn DA.Review of the ethnobotany,chemistry,biological activity and safety of the botanical dietary supplement Morinda citrifolia(noni)[J].J Pharm Pharmacol,2007,59(12):1587-1609.
[3]何其伟,吴培云,梁益敏,等.诺丽果肉化学成分研究[J].中成药,2012,34(9):1729-1733.
[4]刘树民,王宇,张洪财,等.诺丽果的化学成分研究[J].中草药,2012,43(11):2150-2153.
[5]Nayak S,Mengi S.Immunostimulant activity of noni(Morinda citrifolia)on T and B lymphocytes[J].Pharm Biol,2010,48(7):724-731.
[6]Huang HL,Liu CT,Chou MC,et al.Noni(Morinda citrifolia L.)Fruit Extracts Improve Colon Microflora and Exert Anti-Inflammatory Activities in Caco-2 Cells[J].JMed Food,2015,18(6):663-676.
[7]Dussossoy E,Bichon F,Bony E,et al.Pulmonary antiinflammatory effects and spasmolytic properties of Costa Rican noni juice(Morinda citrifolia L.)[J].JEthnopharmacol,2016,192:264-272.
[8]Youn UJ,Park EJ,Kondratyuk TP,et al.Antiinflammatory and Quinone Reductase Inducing Compounds from Fermented Noni(Morinda citrifolia)Juice Exudates[J].J Nat Prod,2016,79(6):1508-1513.
[9]李煦照,于纯淼,陈佳,等.诺丽发酵果汁抗氧化实验研究[J].食品研究与开发,2012,33(5):175-177.
[10]Nayak BS,Marshall JR,Isitor G,et al.Hypoglycemic and Hepatoprotective Activity of Fermented Fruit Juice of Morinda citrifolia(Noni)in Diabetic Rats[J].Evid Based Complement Alternat Med,doi:10.1155/2011/875293.
[11]Brown AC.Anticancer activity of Morinda citrifolia(Noni)fruit:a review[J].Phytother Res,2012,26(10):1427-1440.
[12]Gupta RK,Bajpai D,Singh N.Influence of Morinda citrifolia(Noni)on Expression of DNA Repair Genes in Cervical Cancer Cells[J].Asian Pac J Cancer Prev,2015,16(8):3457-3461.
[13]Lim SL,Mustapha NM,Goh YM,et al.Metastasized lung cancer suppression by Morinda citrifolia(Noni)leaf compared to Erlotinib via anti-inflammatory,endogenous antioxidant responses and apoptotic gene activation[J].Mol Cell Biochem,2016,416(1/2):85-97.
[14]Mandukhail SU,Aziz N,Gilani AH.Studies on antidyslipidemic effects of Morinda citrifolia(Noni)fruit,leaves and root extracts[J].Lipids Health Dis,2010,9:88.
[15]Dussossoy E,Brat P,Bony E,et al.Characterization,anti-oxidative and anti-inflammatory effects of Costa Rican noni juice(Morinda citrifolia L.)[J].J Ethnopharmacol,2011,133(1):108-115.
[16]Stadlbauer V,Weiss S,Payer F,et al.Herbal does not at all mean innocuous:the sixth case of hepatotoxicity associated with morinda citrifolia(noni)[J].Am JGastroenterol,2008,103(9):2406-2407.
[17]Yu EL,Sivagnanam M,Ellis L,et al.Acute hepatotoxicity after ingestion of Morinda citrifolia(Noni Berry)juice in a 14-year-old boy[J].J Pediatr Gastroenterol Nutr,2011,52(2):222-224.
[18]Stadlbauer V,Fickert P,Lackner C,et al.Hepatotoxicity of NONI juice:report of two cases[J].World JGastroenterol,2005,11(30):4758-4760.
[19]Samoylenko V,Zhao J,Dunbar DC,et al.New constituents from noni(Morinda citrifolia)fruit juice[J].J Agric Food Chem,2006,54(17):6398-6402.
[20]Akihisa T,Tochizawa S,Takahashi N,et al.Melanogenesisinhibitory saccharide fatty acid esters and other constituents of the fruits of Morinda citrifolia(noni)[J].Chem Biodivers,2012,9(6):1172-1187.
[21]Bussmann RW,Hennig L,Giannis A,et al.Anthraquinone Content in Noni(Morinda citrifolia L.)[J].Evid Based Complement Alternat Med,2013,2013:208378.
[22]Nerurkar PV,Nishioka A,Eck PO,et al.Regulation of glucose metabolism via hepatic forkhead transcription factor1(Fox O1)by Morinda citrifolia(noni)in high-fat dietinduced obese mice[J].Br J Nutr,2012,108(2):218-228.
[23]林卫华,郑定仙,冯丁山,等.诺丽果粉食用安全性研究[J].中国热带医学,2011,11(12):1509-1511.
[24]West BJ,Su CX,Jensen CJ.Hepatotoxicity and subchronic toxicity tests of Morinda citrifolia(noni)fruit[J].J Toxicol Sci,2009,34(5):581-585.
[2]Pawlus AD,Kinghorn DA.Review of the ethnobotany,chemistry,biological activity and safety of the botanical dietary supplement Morinda citrifolia(noni)[J].J Pharm Pharmacol,2007,59(12):1587-1609.
[3]何其伟,吴培云,梁益敏,等.诺丽果肉化学成分研究[J].中成药,2012,34(9):1729-1733.
[4]刘树民,王宇,张洪财,等.诺丽果的化学成分研究[J].中草药,2012,43(11):2150-2153.
[5]Nayak S,Mengi S.Immunostimulant activity of noni(Morinda citrifolia)on T and B lymphocytes[J].Pharm Biol,2010,48(7):724-731.
[6]Huang HL,Liu CT,Chou MC,et al.Noni(Morinda citrifolia L.)Fruit Extracts Improve Colon Microflora and Exert Anti-Inflammatory Activities in Caco-2 Cells[J].JMed Food,2015,18(6):663-676.
[7]Dussossoy E,Bichon F,Bony E,et al.Pulmonary antiinflammatory effects and spasmolytic properties of Costa Rican noni juice(Morinda citrifolia L.)[J].JEthnopharmacol,2016,192:264-272.
[8]Youn UJ,Park EJ,Kondratyuk TP,et al.Antiinflammatory and Quinone Reductase Inducing Compounds from Fermented Noni(Morinda citrifolia)Juice Exudates[J].J Nat Prod,2016,79(6):1508-1513.
[9]李煦照,于纯淼,陈佳,等.诺丽发酵果汁抗氧化实验研究[J].食品研究与开发,2012,33(5):175-177.
[10]Nayak BS,Marshall JR,Isitor G,et al.Hypoglycemic and Hepatoprotective Activity of Fermented Fruit Juice of Morinda citrifolia(Noni)in Diabetic Rats[J].Evid Based Complement Alternat Med,doi:10.1155/2011/875293.
[11]Brown AC.Anticancer activity of Morinda citrifolia(Noni)fruit:a review[J].Phytother Res,2012,26(10):1427-1440.
[12]Gupta RK,Bajpai D,Singh N.Influence of Morinda citrifolia(Noni)on Expression of DNA Repair Genes in Cervical Cancer Cells[J].Asian Pac J Cancer Prev,2015,16(8):3457-3461.
[13]Lim SL,Mustapha NM,Goh YM,et al.Metastasized lung cancer suppression by Morinda citrifolia(Noni)leaf compared to Erlotinib via anti-inflammatory,endogenous antioxidant responses and apoptotic gene activation[J].Mol Cell Biochem,2016,416(1/2):85-97.
[14]Mandukhail SU,Aziz N,Gilani AH.Studies on antidyslipidemic effects of Morinda citrifolia(Noni)fruit,leaves and root extracts[J].Lipids Health Dis,2010,9:88.
[15]Dussossoy E,Brat P,Bony E,et al.Characterization,anti-oxidative and anti-inflammatory effects of Costa Rican noni juice(Morinda citrifolia L.)[J].J Ethnopharmacol,2011,133(1):108-115.
[16]Stadlbauer V,Weiss S,Payer F,et al.Herbal does not at all mean innocuous:the sixth case of hepatotoxicity associated with morinda citrifolia(noni)[J].Am JGastroenterol,2008,103(9):2406-2407.
[17]Yu EL,Sivagnanam M,Ellis L,et al.Acute hepatotoxicity after ingestion of Morinda citrifolia(Noni Berry)juice in a 14-year-old boy[J].J Pediatr Gastroenterol Nutr,2011,52(2):222-224.
[18]Stadlbauer V,Fickert P,Lackner C,et al.Hepatotoxicity of NONI juice:report of two cases[J].World JGastroenterol,2005,11(30):4758-4760.
[19]Samoylenko V,Zhao J,Dunbar DC,et al.New constituents from noni(Morinda citrifolia)fruit juice[J].J Agric Food Chem,2006,54(17):6398-6402.
[20]Akihisa T,Tochizawa S,Takahashi N,et al.Melanogenesisinhibitory saccharide fatty acid esters and other constituents of the fruits of Morinda citrifolia(noni)[J].Chem Biodivers,2012,9(6):1172-1187.
[21]Bussmann RW,Hennig L,Giannis A,et al.Anthraquinone Content in Noni(Morinda citrifolia L.)[J].Evid Based Complement Alternat Med,2013,2013:208378.
[22]Nerurkar PV,Nishioka A,Eck PO,et al.Regulation of glucose metabolism via hepatic forkhead transcription factor1(Fox O1)by Morinda citrifolia(noni)in high-fat dietinduced obese mice[J].Br J Nutr,2012,108(2):218-228.
[23]林卫华,郑定仙,冯丁山,等.诺丽果粉食用安全性研究[J].中国热带医学,2011,11(12):1509-1511.
[24]West BJ,Su CX,Jensen CJ.Hepatotoxicity and subchronic toxicity tests of Morinda citrifolia(noni)fruit[J].J Toxicol Sci,2009,34(5):581-585.