Apalutamide合成路线图解

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	英文篇名：Graphical Synthetic Routes of Apalutamide 作者：王希 ; 刘水平 英文作者：WANG Xi;LIU Shui-ping;Zhuzhou Institute for Food and Drug Control; 关键词：Apalutamide ; 合成路线图解 英文关键词：Apalutamide;;Graphical Synthetic Routes 中文刊名：HAIX 英文刊名：Strait Pharmaceutical Journal 机构：湖南省株洲市食品药品检验所; 出版日期：2019-04-15 出版单位：海峡药学 年：2019 期：v.31;No.231 语种：中文; 页：HAIX201904017 页数：3 CN：04 ISSN：35-1173/R 分类号：55-57

摘要

目的通过对已有的Apalutamide的合成方法进行分析,从而找到最适宜工业化生产的路线。方法对Apalutamide的合成路线进行概括、归纳。结果与结论路线3原料价廉易的,反应路线短,更加符合工业生产要求。
        OBJECTIVE To review the existing synthetic routes,and find the most ideal synthetic routes of Apalutamide for industrialization.METHODS The different synthetic processes of Apalutamide were generalized.RESULTS and CONCLUSION The route 3 with the starting material ornithine shows more favorable and commercial value in the manufacturing scale.

引文

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