加味桂枝汤对气血两虚型产后风湿病的治疗效果观察
|
摘要
目的:观察加味桂枝汤对气血两虚型产后风湿病的治疗效果。方法:选取2014年8月—2017年7月本院收治的气血两虚型产后风湿病患者46例,根据随机数字法分为观察组和对照组各23例。对照组采用常规雷公藤多甙片治疗,观察组使用加味桂枝汤治疗。比较两组患者临床疗效。结果:治疗后3个月,观察组临床总有效率(95.7%)高于对照组(73.9%),晨僵时间、功能障碍指数、关节肿胀指数、关节压痛指数,以及实验室检测CRP、ESR水平均低于对照组,抑郁自评量表(SDS)评分、和焦虑自评量表(SAS)评分、视觉模拟评分(VAS)低于对照组(均P<0.05)。观察组和对照组不良反应率比较无显著差异(P>0.05)。结论:加味桂枝汤治疗气血两虚型产后风湿病,能有效改善患者临床症状,临床疗效良好,安全性高。
Objective:To study effect of modified guizhi decoction on women with postpartum rheumatism of qi-blood deficiency type.Methods:From August 2014 to July 2017,forty-six women with postpartum rheumatism of qi-blood deficiency type who admitted in Shanghai traditional Chinese medicine university hospital were selected,and were divided into observation group and control group according to the random number(23 cases in each group).The women in control group were treated by regular tripterygium glycosides,and the women in observation group were treated by modified Guizhi decoction.The clinical efficacy of women was compared between the two groups.Results:After 3 months of treatment,the total clinical efficacy in observation group(95.7%)was significantly higher than that of women in control group(73.9%).And the time of morning stiffness,the index of dysfunction,joint swelling,and joint tenderness,and levels of CRP,and ESR of women in observation group were significantly lower than those of women in control group(P<0.05).The depression self-rating scale(SDS)score,SAS score and visual analogue scale(VAS)of women in observation group were significantly lower than those of women in control group(P <0.05).There was no significant difference in the adverse reaction rate between the two groups(P>0.05).Conclusion:Modified Guizhi Decoction used for treating women with postpartum rheumatism of qi-blood deficiency type can improve the clinical symptoms effectively,and has good clinical therapeutic efficacy and safety.
Objective:To study effect of modified guizhi decoction on women with postpartum rheumatism of qi-blood deficiency type.Methods:From August 2014 to July 2017,forty-six women with postpartum rheumatism of qi-blood deficiency type who admitted in Shanghai traditional Chinese medicine university hospital were selected,and were divided into observation group and control group according to the random number(23 cases in each group).The women in control group were treated by regular tripterygium glycosides,and the women in observation group were treated by modified Guizhi decoction.The clinical efficacy of women was compared between the two groups.Results:After 3 months of treatment,the total clinical efficacy in observation group(95.7%)was significantly higher than that of women in control group(73.9%).And the time of morning stiffness,the index of dysfunction,joint swelling,and joint tenderness,and levels of CRP,and ESR of women in observation group were significantly lower than those of women in control group(P<0.05).The depression self-rating scale(SDS)score,SAS score and visual analogue scale(VAS)of women in observation group were significantly lower than those of women in control group(P <0.05).There was no significant difference in the adverse reaction rate between the two groups(P>0.05).Conclusion:Modified Guizhi Decoction used for treating women with postpartum rheumatism of qi-blood deficiency type can improve the clinical symptoms effectively,and has good clinical therapeutic efficacy and safety.
引文
[1]G9testam SC,Lydersen S,Gilboe IM,et al.Disease Activity During Pregnancy and the First Year Postpartum in Women With Systemic Lupus Erythematosus[J].Arthritis care&research,2017,69(8):1201-1208.
[2]Bermas BL.Lactation and Management of Postpartum Disease[J].Rheumatic diseases clinics of North America,2017,43(2):249-262.
[3]刘蔚翔,施雨,陈进春.柴胡桂枝汤治疗类风湿关节炎初探[J].中华中医药杂志,2018,33(01):148-150.
[4]娄玉珍.中医风湿病[M].北京:人民卫生出版社,2010:308.
[5]吴启富,范永中,叶志中.常见风湿病中西医结合诊疗指南(草案)[J].中药药理与临床,2013,12(5):150-155.
[6]杨会军,刘维超,李兆福,吴晶金,彭江云.温阳通络法治疗风湿病的临床应用[J].中国中医基础医学杂志,2017,23(01):51-52+59.
[7]张娜,王晓非,程瑶.利妥昔单抗治疗风湿性疾病的研究进展[J].山东医药,2015,55(21):92-94.
[8]何伟珍,尹志华,高建华,等.依那西普联合雷公藤多苷治疗老年类风湿关节炎的临床观察[J].中国中西医结合杂志,2014,34(3):267-271.
[9]涂胜豪,陈哲.雷公藤治疗类风湿关节炎的现状和存在的问题[J].中西医结合研究,2009,1(1):42-44.
[10]Fraenkel L,Nowell WB,Michel G,et al.Preference phenotypes to facilitate shared decision-making in rheumatoid arthritis[J].Annals of the rheumatic diseases,2018,77(5):678-683.
[11]羊维,刘芬芬,包洁,等.产后风湿“血郁同病”的病因病机探索[J].中华中医药杂志,2015,30(01):20-22.
[12]吴启富,范永中,叶志中.常见风湿病中西医结合诊疗指南(草案)骨关节炎中西医结合诊疗指南[J].中药药理与临床,2013,29(6):150-155.
[13]毛晓红.当归补血汤合桂枝汤治疗类风湿性关节炎33例疗效观察[J].中药药理与临床,2015,31(01):294-295.
[14]施学丽,郭超峰,邓小敏,等.桂枝汤方证关系的研究探讨[J].辽宁中医杂志,2016,43(12):2516-2517.
[15]黄爱华,张玉兴,沈大政.宣痹汤合白虎桂枝汤内服外洗治疗急性痛风性关节炎57例临床观察[J].中国实验方剂学杂志,2015,21(20):192-195.
[2]Bermas BL.Lactation and Management of Postpartum Disease[J].Rheumatic diseases clinics of North America,2017,43(2):249-262.
[3]刘蔚翔,施雨,陈进春.柴胡桂枝汤治疗类风湿关节炎初探[J].中华中医药杂志,2018,33(01):148-150.
[4]娄玉珍.中医风湿病[M].北京:人民卫生出版社,2010:308.
[5]吴启富,范永中,叶志中.常见风湿病中西医结合诊疗指南(草案)[J].中药药理与临床,2013,12(5):150-155.
[6]杨会军,刘维超,李兆福,吴晶金,彭江云.温阳通络法治疗风湿病的临床应用[J].中国中医基础医学杂志,2017,23(01):51-52+59.
[7]张娜,王晓非,程瑶.利妥昔单抗治疗风湿性疾病的研究进展[J].山东医药,2015,55(21):92-94.
[8]何伟珍,尹志华,高建华,等.依那西普联合雷公藤多苷治疗老年类风湿关节炎的临床观察[J].中国中西医结合杂志,2014,34(3):267-271.
[9]涂胜豪,陈哲.雷公藤治疗类风湿关节炎的现状和存在的问题[J].中西医结合研究,2009,1(1):42-44.
[10]Fraenkel L,Nowell WB,Michel G,et al.Preference phenotypes to facilitate shared decision-making in rheumatoid arthritis[J].Annals of the rheumatic diseases,2018,77(5):678-683.
[11]羊维,刘芬芬,包洁,等.产后风湿“血郁同病”的病因病机探索[J].中华中医药杂志,2015,30(01):20-22.
[12]吴启富,范永中,叶志中.常见风湿病中西医结合诊疗指南(草案)骨关节炎中西医结合诊疗指南[J].中药药理与临床,2013,29(6):150-155.
[13]毛晓红.当归补血汤合桂枝汤治疗类风湿性关节炎33例疗效观察[J].中药药理与临床,2015,31(01):294-295.
[14]施学丽,郭超峰,邓小敏,等.桂枝汤方证关系的研究探讨[J].辽宁中医杂志,2016,43(12):2516-2517.
[15]黄爱华,张玉兴,沈大政.宣痹汤合白虎桂枝汤内服外洗治疗急性痛风性关节炎57例临床观察[J].中国实验方剂学杂志,2015,21(20):192-195.