两亲性壳聚糖衍生物的制备及其负载氧化铁纳米粒子
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摘要
功能性高分子的主链选用壳聚糖,利用西弗碱反应制备了癸基化壳聚糖与具有亲疏水性质的羧甲基化癸基化壳聚糖衍生物。通过疏水相互作用,制备了壳聚糖负载氧化铁复合纳米粒子,复合粒子为超顺磁性,分散良好,尺寸均一,性质稳定,生物相容性好。
Alkyl-chitosan derivatives(decyl chitosan)and N-decyl-O,N-carboxymethyl chitosan were successfully synthesized with chitosan acting as main chain of the grafted polymers.The water-soluble magnetic composite nanoparticles were achieved by incorporation of iron oxide nanoparticles(IO)inside the polymeric micelle core through hydrophobic interaction.The vibrating sample magnetometry(VSM),AFM,TEM,DLS and MTT results indicated that the CMDCTS@IO composite nanoparticles with narrow size distribution were prepared,which showed that the nanoparticles had good superparamagnetism,good water solubility and low cytotoxicity.
Alkyl-chitosan derivatives(decyl chitosan)and N-decyl-O,N-carboxymethyl chitosan were successfully synthesized with chitosan acting as main chain of the grafted polymers.The water-soluble magnetic composite nanoparticles were achieved by incorporation of iron oxide nanoparticles(IO)inside the polymeric micelle core through hydrophobic interaction.The vibrating sample magnetometry(VSM),AFM,TEM,DLS and MTT results indicated that the CMDCTS@IO composite nanoparticles with narrow size distribution were prepared,which showed that the nanoparticles had good superparamagnetism,good water solubility and low cytotoxicity.
引文
[1]施晓文,李晓霞,杜予民.甲壳素基新材料研究进展[J].高分子学报,2011,(1):1-11.
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[8]孙婷,杨伯函,李昆,李亚鹏,王静媛.两亲性梳形共聚物PASPNa-g-DDA的合成及接枝率对其水溶液胶束性质的影响[J].高分子学报,2011,(10):1138-1143.
[9]李昆,孙婷,孙媛,杨伯函,孟新蕾,李亚鹏,王静媛.两亲性壳聚糖衍生物的制备及其包覆量子点[J].高分子学报,2012,(2):180-186.
[10]吴战宇,撒宗鹏,邱芳萍,赵义丽,李亚鹏,王书唯,王静媛.多功能两亲梳状聚合物的合成及包覆荧光量子点[J].高分子学报,2010,(5):516-521.
[11]Hong R,Fischer N O,Emrick T,Rotello V M.Surface PE gylation and ligand exchange chemistry of FePt nanoparticles for biological applications[J].Chem Mater,2005,17(18):4617.
[12]Euliss L E,Grancharov S G,O’brien S,et al.Cooperative assembly of magnetic nanoparticles and block copolypeptides in aqueous media[J].Nano Lett,2003,3(11):1489.
[13]吴战宇.功能性聚合物的合成及靶向载药纳米粒子的研究[D].吉林:吉林大学化学学院,2010.
[14]李昆.两亲性壳聚糖衍生物的制备及其包覆纳米粒子[D].吉林:吉林大学化学学院,2012.
[2]蓝凤祥.壳聚糖的应用和制备[J].化工新型材料,2002,30(3):22-24.
[3]张高飞,黄国林.磁性壳聚糖微球的制备及其应用研究[J].化工新型材料,2011,39(5):15-17.
[4]单丹彤,谢飞,李若慧.壳聚糖的生物医学特性与其结构的关系研究进展[J].化工新型材料,2011,39(5):19-21.
[5]Mourya V K,Inamdar N N.Chitosan-modifications and applications:Opportunities galore[J].Reactive&Functional Polymers,2008,68:1031-1051.
[6]Widder K J,Senyei A E,Scarpelli D G.Magnetic microspheres:A model system for site specific drug delivery in vivo[J].Proc Soc Exp Biol Med,1978,58:141.
[7]Neuberger T,Schpf B,Hofmann H,et al.Superparamagnetic nanoparticles for biomedical applications:Possibilities and limitations of a new drug delivery system[J].J Magn Magn Mater,2005,293(1):483-496.
[8]孙婷,杨伯函,李昆,李亚鹏,王静媛.两亲性梳形共聚物PASPNa-g-DDA的合成及接枝率对其水溶液胶束性质的影响[J].高分子学报,2011,(10):1138-1143.
[9]李昆,孙婷,孙媛,杨伯函,孟新蕾,李亚鹏,王静媛.两亲性壳聚糖衍生物的制备及其包覆量子点[J].高分子学报,2012,(2):180-186.
[10]吴战宇,撒宗鹏,邱芳萍,赵义丽,李亚鹏,王书唯,王静媛.多功能两亲梳状聚合物的合成及包覆荧光量子点[J].高分子学报,2010,(5):516-521.
[11]Hong R,Fischer N O,Emrick T,Rotello V M.Surface PE gylation and ligand exchange chemistry of FePt nanoparticles for biological applications[J].Chem Mater,2005,17(18):4617.
[12]Euliss L E,Grancharov S G,O’brien S,et al.Cooperative assembly of magnetic nanoparticles and block copolypeptides in aqueous media[J].Nano Lett,2003,3(11):1489.
[13]吴战宇.功能性聚合物的合成及靶向载药纳米粒子的研究[D].吉林:吉林大学化学学院,2010.
[14]李昆.两亲性壳聚糖衍生物的制备及其包覆纳米粒子[D].吉林:吉林大学化学学院,2012.