加味人参汤联合常规西药治疗脾胃虚寒型胃溃疡临床疗效观察
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摘要
目的:探讨加味人参汤联合常规西药治疗脾胃虚寒型胃溃疡临床疗效观察。方法:将2014年12月-2015年12月在本院消化内科治疗的120例脾胃虚寒型胃溃疡患者随机分为两组,对照组采用西医常规治疗,观察组采用加味人参汤联合常规西药治疗,比较两组患者的治疗效果、中医证候改善情况、溃疡面积、Hp清除率及复发情况。结果:观察组治疗有效率为96.67%,显著高于对照组的83.33%,差异有统计学意义(P<0.05);观察组治疗后胃痛胃胀、反酸嗳气、倦怠乏力、畏寒肢冷、神疲懒言等中医证候积分明显低于对照组,差异有统计学意义(P<0.05);观察组治疗后溃疡面积明显小于对照组,差异有统计学意义(P<0.05);观察组Hp根除率为93.33%,明显高于对照组的75%,观察组1年复发率为3.33%,明显低于对照组的21.67%,差异有统计学意义(P<0.05)。结论:加味人参汤联合常规西药治疗脾胃虚寒型胃溃疡效果显著,能够提高Hp根除率,促进溃疡面愈合,减少复发,具有积极的临床意义。
Objective: To investigate the Modified Ginseng Decoction combined with conventional Western medicine in treatment of spleen deficiency type of gastric ulcer. Methods: A totla of 120 patients with spleen deficiency type of gastric ulcer in the Department of Gastroenterology in our hospital from December 2014 to December 2015 were randomly divided into two groups. The control group was treated with conventional Western medicine,while the observation group was treated with Modified Ginseng Decoction combined with conventional Western medicine. We compared the two groups' treatment effect,TCM symptoms,ulcer area,Hp clearance rate and recurrence. Results: The effective rate of the observation group was significantly higher than that of the control group and the difference was statistically significant( P < 0. 05). After treatment,the observation group' s stomach bloating,belching,acid regurgitation,lassitude,aversion to cold,fatigue,less talking and symptom scores were significantly lower than those of the control group and the difference was statistically significant( P < 0. 05). The ulcer area in the observation group was significantly lower than that in the control group and the difference was statistically significant( P < 0. 05). The eradication rate of Hp in the observation group was significantly higher than that in the control groupand the recurrence rate in the observation group was significantly lower than that in the control group( P < 0. 05). Conclusion: Ginseng Decoction combined with conventional Western medicine was effective in the treatment of spleen deficiency type of gastric ulcer and can improve the eradication rate of Hp,promote ulcer healing and reduce the recurrence,with positive clinical significance.
Objective: To investigate the Modified Ginseng Decoction combined with conventional Western medicine in treatment of spleen deficiency type of gastric ulcer. Methods: A totla of 120 patients with spleen deficiency type of gastric ulcer in the Department of Gastroenterology in our hospital from December 2014 to December 2015 were randomly divided into two groups. The control group was treated with conventional Western medicine,while the observation group was treated with Modified Ginseng Decoction combined with conventional Western medicine. We compared the two groups' treatment effect,TCM symptoms,ulcer area,Hp clearance rate and recurrence. Results: The effective rate of the observation group was significantly higher than that of the control group and the difference was statistically significant( P < 0. 05). After treatment,the observation group' s stomach bloating,belching,acid regurgitation,lassitude,aversion to cold,fatigue,less talking and symptom scores were significantly lower than those of the control group and the difference was statistically significant( P < 0. 05). The ulcer area in the observation group was significantly lower than that in the control group and the difference was statistically significant( P < 0. 05). The eradication rate of Hp in the observation group was significantly higher than that in the control groupand the recurrence rate in the observation group was significantly lower than that in the control group( P < 0. 05). Conclusion: Ginseng Decoction combined with conventional Western medicine was effective in the treatment of spleen deficiency type of gastric ulcer and can improve the eradication rate of Hp,promote ulcer healing and reduce the recurrence,with positive clinical significance.
引文
[1]张强强.加味人参汤治疗脾胃虚寒型胃溃疡的临床研究[D].哈尔滨:黑龙江中医药大学,2010:1-55.
[2]李静.黄芪建中汤加减治疗脾胃虚寒型胃溃疡临床分析[J].深圳中西医结合杂志,2015,25(22):54-55.
[3]文驰,梁锦汉,陈刘庆,等.黄芪建中汤加减治疗脾胃虚寒型胃溃疡72例疗效观察[J].现代医药卫生,2015,31(2):270-272.
[4]夏飞.中西医结合治疗胃溃疡脾胃虚寒型80例观察[J].实用中医药杂志,2012,30(12):1119.
[5]金姣君,楼巧勤,叶育双.中西医结合治疗脾胃虚寒型消化性溃疡临床研究[J].新中医,2015,47(4):91-92.
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[7]高庆元.黄芪建中丸联合奥美拉唑治疗脾胃虚寒型胃溃疡的临床观察[J].中国临床药理学与治疗学,2015,20(3):323-326.
[8]乔明飞.黄芪建中汤加减配合丽珠维三联治疗脾胃虚寒型胃溃疡临床疗效观察[J].内蒙古中医药,2016,35(4):59-60.
[9]朱继臣.益气健脾方联合西药治疗脾胃虚寒型胃溃疡疗效观察[J].新中医,2014,46(6):77-78.
[10]解刘松,韦怡.温中消疡汤联合西药治疗胃溃疡脾胃虚寒型40例临床观察[J].中医药导报,2013,19(11):38-39.
[11]刘敏,周亚滨,孙世林,等.附子理中汤治疗脾胃虚寒型胃溃疡机制的研究[J].中医药学报,2012,40(4):42-44.
[12]赵昌.大建中汤治疗胃溃疡_脾胃阳虚型_的临床研究[D].太原:山西中医学院,2014:1-27.
[13]赵茂森.中医辨证联合西医常规治疗胃溃疡合并出血临床观察[J].河北中医,2016,38(2):224-227.
[14]王惠霞.西医三联疗法联合中医汤剂治疗胃溃疡的效果分析[J].中医临床研究,2016,8(23):59-60.
[15]郝小鹰,刘溯,李兴华,等.安胃汤加减联合常规西医治疗胃溃疡的疗效观察[J].陕西中医,2016,37(7):864-866.
[2]李静.黄芪建中汤加减治疗脾胃虚寒型胃溃疡临床分析[J].深圳中西医结合杂志,2015,25(22):54-55.
[3]文驰,梁锦汉,陈刘庆,等.黄芪建中汤加减治疗脾胃虚寒型胃溃疡72例疗效观察[J].现代医药卫生,2015,31(2):270-272.
[4]夏飞.中西医结合治疗胃溃疡脾胃虚寒型80例观察[J].实用中医药杂志,2012,30(12):1119.
[5]金姣君,楼巧勤,叶育双.中西医结合治疗脾胃虚寒型消化性溃疡临床研究[J].新中医,2015,47(4):91-92.
[6]廖锦秀.中西医结合治疗脾胃虚寒型消化性溃疡临床观察[J].现代诊断与治疗,2014,25(12):2687-2689.
[7]高庆元.黄芪建中丸联合奥美拉唑治疗脾胃虚寒型胃溃疡的临床观察[J].中国临床药理学与治疗学,2015,20(3):323-326.
[8]乔明飞.黄芪建中汤加减配合丽珠维三联治疗脾胃虚寒型胃溃疡临床疗效观察[J].内蒙古中医药,2016,35(4):59-60.
[9]朱继臣.益气健脾方联合西药治疗脾胃虚寒型胃溃疡疗效观察[J].新中医,2014,46(6):77-78.
[10]解刘松,韦怡.温中消疡汤联合西药治疗胃溃疡脾胃虚寒型40例临床观察[J].中医药导报,2013,19(11):38-39.
[11]刘敏,周亚滨,孙世林,等.附子理中汤治疗脾胃虚寒型胃溃疡机制的研究[J].中医药学报,2012,40(4):42-44.
[12]赵昌.大建中汤治疗胃溃疡_脾胃阳虚型_的临床研究[D].太原:山西中医学院,2014:1-27.
[13]赵茂森.中医辨证联合西医常规治疗胃溃疡合并出血临床观察[J].河北中医,2016,38(2):224-227.
[14]王惠霞.西医三联疗法联合中医汤剂治疗胃溃疡的效果分析[J].中医临床研究,2016,8(23):59-60.
[15]郝小鹰,刘溯,李兴华,等.安胃汤加减联合常规西医治疗胃溃疡的疗效观察[J].陕西中医,2016,37(7):864-866.