不同程度远视屈光参差性弱视的波前像差特点
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摘要
目的:评估不同程度远视屈光参差性弱视的波前像差特点。方法:远视屈光参差性弱视60例被纳入本研究,并被分成轻、中、重度三组,各组按矫正视力再分为弱视眼与对侧眼亚组。所有患者双眼均接受散瞳后波前像差检测。分析组内和组间双眼间波前像差差异。结果:轻、中、重度弱视各组内弱视眼与对侧眼的等效离焦度、矫正视力均有差异(P<0.01)。轻度弱视患者中,弱视眼仅四阶像差RMS值高于对侧眼(P<0.01);中、重度弱视组内弱视眼仅总像差RMS值高于对侧眼(均P<0.01)。三组间仅双眼间三阶像差RMS差值有差异(P<0.01),中度与轻度、重度组间均有差异(P<0.05)。结论:散瞳状态下,双眼间波前像差在轻度弱视表现为弱视眼四阶像差RMS值高于对侧眼,在中、重度弱视表现为弱视眼的总像差RMS值高于对侧眼;双眼间波前像差RMS差值在屈光参差性弱视表现为中度弱视的三阶像差RMS差值低于轻度、重度弱视。
·AIM: To evaluate the interocular aberration root mean squares(RMS) characteristics among different severities of hyperopic anisometropic amblyopia.·METHODS: Sixty hyperopic anisometropic amblyopia were enrolled and divided into mild, moderate and severe groups. Each group was then divided into amblyopic eye(AE) and fellow eye(FE) subgroups according to the corrected visual acuity of each subject. All patients underwent wavefront analysis with iDesign© wavefront aberration system(AMO, USA) in mydriasis condition. Paired t-test was used to compare interocular differences of aberration parameters within groups. ·RESULTS: Paired t-test showed that significant differences in defocus equivalent(DE), BCVA between AE and FE in mild, moderate and severe anisometropic amblyopia(all P<0.01). No significant interocular difference was noticed in mild group except for forth-order aberration RMS(P<0.01). And No significant interocular differences were noticed in moderate and severe group except for total aberration RMS(both P<0.01). One-way ANOVA showed that significant interocular differences were noticed in third-order aberration RMS among the groups(P<0.01). LSD showed that interocular difference of third-order aberration RMS in moderate group was significant lower than that in mild and moderate groups(both P<0.05). ·CONCLUSION: In mydriasis condition, mild anisometropic amblyopia showed higher forth-order aberration RMS in AE than that in FE, moderate and sever amblyopia showed higher total aberration RMS in AE than that in FE. Moderate anisometropic amblyopia manifested lower interocular differences of third-order aberrations RMS than mild and severe amblyopia, but no significant interocular differences observed between mild and severe amblyopia.
·AIM: To evaluate the interocular aberration root mean squares(RMS) characteristics among different severities of hyperopic anisometropic amblyopia.·METHODS: Sixty hyperopic anisometropic amblyopia were enrolled and divided into mild, moderate and severe groups. Each group was then divided into amblyopic eye(AE) and fellow eye(FE) subgroups according to the corrected visual acuity of each subject. All patients underwent wavefront analysis with iDesign© wavefront aberration system(AMO, USA) in mydriasis condition. Paired t-test was used to compare interocular differences of aberration parameters within groups. ·RESULTS: Paired t-test showed that significant differences in defocus equivalent(DE), BCVA between AE and FE in mild, moderate and severe anisometropic amblyopia(all P<0.01). No significant interocular difference was noticed in mild group except for forth-order aberration RMS(P<0.01). And No significant interocular differences were noticed in moderate and severe group except for total aberration RMS(both P<0.01). One-way ANOVA showed that significant interocular differences were noticed in third-order aberration RMS among the groups(P<0.01). LSD showed that interocular difference of third-order aberration RMS in moderate group was significant lower than that in mild and moderate groups(both P<0.05). ·CONCLUSION: In mydriasis condition, mild anisometropic amblyopia showed higher forth-order aberration RMS in AE than that in FE, moderate and sever amblyopia showed higher total aberration RMS in AE than that in FE. Moderate anisometropic amblyopia manifested lower interocular differences of third-order aberrations RMS than mild and severe amblyopia, but no significant interocular differences observed between mild and severe amblyopia.
引文
1 Jia W, Lan F, Zhao X, et al. The effects of monocular training on binocular functions in anisometropic amblyopia. Vision Res 2018;152:74-83
2 von Noorden GK, Campos EC. Patching regimens. Ophthalmology 2004;111(5):1063
3 Liang J, Grimm B, Geolz S, et al. Objective measurement of wave aberrations of the eye with the use of a Hartmann-Shack wave-front sensor. J Opt Soc Am A 1994;11:1949-1957
4 Zhao PF, Zhou YH, Wang NL, et al. Study of the wavefront aberrations in children with amblyopia. Chin Med J (Engl) 2010;123(11):1431-1435
5 Vincent SJ, Collins MJ, Read SA, et al. Monocular amblyopia and higher order aberrations. Vision Res 2012;66:39-48
6 Prakash G, Sharma N, Saxena R, et al. Comparison of higher order aberration profiles between normal and amblyopic eyes in children with idiopathic amblyopia. Acta Ophthalmol 2011;89(3):e257-262
7 Plech AR, Pinero DP, Laria C, et al. Corneal higher-order aberrations in amblyopia. Eur J Ophthalmol 2010;20(1):12-20
8 Agarwal A, Prakash G, Jacob S, et al. Can uncompensated higher order aberration profile, or aberropia be responsible for subnormal best corrected vision and pseudo-amblyopia. Med Hypotheses 2009;72(5):574-577
9 Prakash G, Sharma N, Chowdhary V, et al. Association between amblyopia and higher-order aberrations. J Cataract Refract Surg 2007;33(5):901-904
10赵武校,蓝方方,李志超,等. 波前像差在屈光参差性弱视光学质量评估中的应用.眼科新进展 2015;35(10):939-944
11赵武校,蓝方方,罗妍,等. 屈光参差性弱视与屈光参差性近视双眼间高阶像差特征的对比研究.眼科新进展 2016;36(2):146-150
12中华医学会眼科学分会斜视与小儿眼科学组. 弱视诊断专家共识(2011年).中华眼科杂志 2011;47(8):478
13 Thibos LN, Applegate RA, Schwiegerling JT, et al. Vision science and its applications. Standards for reporting the optical aberrations of eyes. J Refract Surg 2002;18(5):S652-S660
14 Dai Y, Zhao L, Xiao F, et al. Adaptive optics vision simulation and perceptual learning system based on a 35-element bimorph deformable mirror. Appl Opt 2015;54(5):979-985
15 Choi SK, Chang JW. Higher Order Aberration and Astigmatism in Children with Hyperopic Amblyopia. Korean J Ophthalmol 2016;30(1):53-59
16 Chakraborty R, Read SA, Collins MJ. Diurnal variations in ocular aberrations of human eyes. Curr Eye Res 2014;39(3):271-281
2 von Noorden GK, Campos EC. Patching regimens. Ophthalmology 2004;111(5):1063
3 Liang J, Grimm B, Geolz S, et al. Objective measurement of wave aberrations of the eye with the use of a Hartmann-Shack wave-front sensor. J Opt Soc Am A 1994;11:1949-1957
4 Zhao PF, Zhou YH, Wang NL, et al. Study of the wavefront aberrations in children with amblyopia. Chin Med J (Engl) 2010;123(11):1431-1435
5 Vincent SJ, Collins MJ, Read SA, et al. Monocular amblyopia and higher order aberrations. Vision Res 2012;66:39-48
6 Prakash G, Sharma N, Saxena R, et al. Comparison of higher order aberration profiles between normal and amblyopic eyes in children with idiopathic amblyopia. Acta Ophthalmol 2011;89(3):e257-262
7 Plech AR, Pinero DP, Laria C, et al. Corneal higher-order aberrations in amblyopia. Eur J Ophthalmol 2010;20(1):12-20
8 Agarwal A, Prakash G, Jacob S, et al. Can uncompensated higher order aberration profile, or aberropia be responsible for subnormal best corrected vision and pseudo-amblyopia. Med Hypotheses 2009;72(5):574-577
9 Prakash G, Sharma N, Chowdhary V, et al. Association between amblyopia and higher-order aberrations. J Cataract Refract Surg 2007;33(5):901-904
10赵武校,蓝方方,李志超,等. 波前像差在屈光参差性弱视光学质量评估中的应用.眼科新进展 2015;35(10):939-944
11赵武校,蓝方方,罗妍,等. 屈光参差性弱视与屈光参差性近视双眼间高阶像差特征的对比研究.眼科新进展 2016;36(2):146-150
12中华医学会眼科学分会斜视与小儿眼科学组. 弱视诊断专家共识(2011年).中华眼科杂志 2011;47(8):478
13 Thibos LN, Applegate RA, Schwiegerling JT, et al. Vision science and its applications. Standards for reporting the optical aberrations of eyes. J Refract Surg 2002;18(5):S652-S660
14 Dai Y, Zhao L, Xiao F, et al. Adaptive optics vision simulation and perceptual learning system based on a 35-element bimorph deformable mirror. Appl Opt 2015;54(5):979-985
15 Choi SK, Chang JW. Higher Order Aberration and Astigmatism in Children with Hyperopic Amblyopia. Korean J Ophthalmol 2016;30(1):53-59
16 Chakraborty R, Read SA, Collins MJ. Diurnal variations in ocular aberrations of human eyes. Curr Eye Res 2014;39(3):271-281