热层析在乳腺疾病诊疗中的临床应用进展
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摘要
人体内细胞不断的新陈代谢可以产生热辐射,组织的病理改变使局部新陈代谢发生变化,进而导致局部的热辐射发生相应的改变。热层析成像技术通过对人体组织的热分布变化的检测,运用Pennes生物传热方程,寻找热辐射与疾病的内在联系,进行医学研究与临床诊断。热层析成像技术在中、西医都有相关临床应用,成为临床工作中的补充影像技术。在乳腺疾病方面,该技术可以进行疾病早期检出并做出初步诊断;另外对于局部晚期乳腺癌新辅助化疗的患者,可以一定程度上监测瘤体对于化疗药物的疗效反应。文章就热层析在乳腺疾病的临床应用现状及进展予以综述。
The continuous metabolism of cells in the human body can produce thermal radiation, and the pathological changes of tissues can cause changes in local metabolism, which leads to the corresponding changes of local thermal radiation. Thermal tomography technology can be used to detect the change of heat distribution in human tissues and then find the internal relationships between heat radiation and disease via Pennes bio-heat transfer equation, so as to perform medical research and clinical diagnosis. Thermal tomography has been used in both traditional Chinese medicine and western medicine as a complementary imaging technique in clinic. In the case of breast diseases, thermal tomography can detect the disease at early stage and make a preliminary diagnosis. In addition, thermal tomography can monitor the tumor response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. Herein the application and development of thermal chromatography in breast disease are reviewed.
The continuous metabolism of cells in the human body can produce thermal radiation, and the pathological changes of tissues can cause changes in local metabolism, which leads to the corresponding changes of local thermal radiation. Thermal tomography technology can be used to detect the change of heat distribution in human tissues and then find the internal relationships between heat radiation and disease via Pennes bio-heat transfer equation, so as to perform medical research and clinical diagnosis. Thermal tomography has been used in both traditional Chinese medicine and western medicine as a complementary imaging technique in clinic. In the case of breast diseases, thermal tomography can detect the disease at early stage and make a preliminary diagnosis. In addition, thermal tomography can monitor the tumor response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. Herein the application and development of thermal chromatography in breast disease are reviewed.
引文
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[25]WU Q,LI J,SUN S,et al.Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer[J].Oncotarget,2017,8(40):68974-68983.
[26]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2017年版)[J].中国癌症杂志,2017,27(9):695-759.Chinese Anti-Cancer Association,Committee of Breast Cancer Society.China anti-cancer association breast cancer diagnosis and treatment guidelines and regulations(2017 edition)[J].China Oncology,2017,27(9):695-759.
[27]霍慧萍,霍建彬,万文博,等.三阴性裸鼠乳腺癌模型的构建及热层析检测[J].中国医学科学院学报,2016,38(2):198-204.HUO H P,HUO J B,WAN W B,et al.Construction of nude mouse model of triple negative breast cancer and value of thermal tomography[J].Acta Academiae Medicinae Sinicae,2016,38(2):198-204.
[2]TORRE LA,BRAY F,SIEGEL R L,et al.Global cancer statistics,2012[J].CA Cancer J Clin,2015,65(2):87-108.
[3]DAS K,SINGH R,MISHRA S C.Numerical analysis for determination of the presence of a tumor and estimation of its size and location in a tissue[J].J Therm Biol,2013,38(1):32-40.
[4]ZHOU J H,ZHANG Y W,CHEN J K.Non-fourier heat conduction effect on laser-induced thermal damage in biological tissues[J].Numer Heat Tr A-Appl,2008,54(1):1-19.
[5]DAS K,MISHRA S C.Estimation of tumor characteristics in a breast tissue with known skin surface temperature[J].J Therm Biol,2013,38(1):311-317.
[6]BLOOMQUIST A K,YAFFE M J,PISANO E D,et al.Quality control for digital mammography in the ACRIN DMIST trial:part I[J].Med Phys,2006,33(3):719-736.
[7]YAFFE M J,BLOOMQUIST A K,MAWDSLEY G E,et al.Quality control for digital mammography:part II recommendations from the ACRIN DMIST trial[J].Med Phys,2006,33(3):737-752.
[8]KOSUS N,KOSUS A,DURAN M,et al.Comparison of standard mammography with digital mammography and digital infrared thermal imaging for breast cancer screening[J].J Turk Ger Gynecol Assoc,2010,11(3):152-157.
[9]LAPAYOWKER M S,REVESZ G.Thermography and ultrasound in detection and diagnosis of breast cancer[J].Cancer,1980,46(1):933-938.
[10]李昶田,李俊来,贾红超,等.声联合热层析成像诊断乳腺癌的价值[J].中国医学影像技术,2012,28(8):1525-1528.LI C T,LI J L,JIA H C,et al.Value of ultrasound combined with thermal texture maps in diagnosis of breast cancer[J].Chinese Journal of Medical Imaging Technology,2012,28(8):1525-1528.
[11]MILOSEVIC M,JANKOVIC D,PEULIC A.Thermography based breast cancer detection using texture features and minimum variance quantization[J].EXCLI J,2014,13(3):1204-1215.
[12]SHI G L,HAN F,WANG L,et al.Q-r curve of thermal tomography and its clinical application on breast tumor diagnosis[J].Biomed Opt Express,2015,6(4):1109.
[13]WAN X,WANG P,ZHANG H.Thermal computed tomography for biological tissue reconstruction based on radiation balance[J].Biomed Mater Eng,2014,24(1):1157-1165.
[14]FIBICH G,HAMMER A,GANNOT G,et al.Modeling and simulations of the pharmacokinetics of fluorophore conjugated antibodies in tumor vicinity for the optimization of fluorescencebased optical imaging[J].Lasers Surg Med,2005,37(2):155-160.
[15]ACHARYA U R,NG E Y,TAN J H,et al.Thermography based breast cancer detection using texture features and support vector machine[J].J Med Syst,2012,36(3):1503-1510.
[16]YAO X L,WEI W,LI J J.A comparison of mammography,ultrasonography,and far-infrared thermography with pathological results in screening and early diagnosis of breast cancer[J].Asian Biomed,2014,1(8):11-19.
[17]RASSIWALA M,MATHUR P,MATHUR R,et al.Evaluation of digital infra-red thermal imaging as an adjunctive screening method for breast carcinoma:a pilot study[J].Int J Surg,2014,12(12):1439-1443.
[18]何玉霜,彭玉兰,金亚,等.热层析成像联合超声检查对乳腺癌功能形态学的初步研究[J].四川大学学报(医学版),2016,47(1):93-96.HE Y S,PENG Y L,JIN Y,et al.Breast thermal tomography and high frequency ultrasound imaging in predicting breast cancer:a preliminary study[J].Journal of Sichuan University(Medical Science Edition),2016,47(1):93-96.
[19]何玉霜,彭玉兰,金亚,等.热层析成像联合高频超声对T_1期乳腺癌的诊断价值[J].中华医学超声杂志(电子版),2016,13(1):17-20.HE Y S,PENG Y L,JIN Y,et al.Breast thermal tomography and high frequency ultrasound imaging in predicting small breast cancer[J].Chinese Journal of Medical Ultrasound(Electronic Edition),2016,13(1):17-20.
[20]李俊来,李昶田,贾红,等.热层析成像温度分布在乳腺疾病中的诊断价值[J].中国医学影像学杂志,2014,22(4):241-243.LI J L,LI C T,JIA H,et al.Breast diseases:temperature change detected by thermal texture imaging[J].Chinese Journal of Medical Imaging,2014,22(4):241-243.
[21]鲍丽,韩飞,范强,等.热层析成像技术在乳腺体检中的应用价值[J].放射学实践,2014,29(2):170-172.BAO L,HAN F,FAN Q,et al.Study on the application value of thermal tomography technology in physical examination[J].Radiologic Practice,2014,29(2):170-172..
[22]贾红,高登发,佟海燕,等.热层析成像对乳腺疾病诊断价值的探讨[J].医疗卫生装备,2017,38(4):81-83.JIA H,GAO D F,TONG H Y,et al.Clinical value of thermal tomography in diagnosis of breast disease[J].Chinese Medical Equipment Journal,2017,38(4):81-83.
[23]CAUDLE A S,GONZALEZ-ANGULO A M,HUNT K K,et al.Predictors of tumor progression during neoadjuvant chemotherapy in breast cancer[J].J Clin Oncol,2010,28(11):1821-1828.
[24]FEI F,MESSINA C,SLAETS L,et al.Tumour size is the only predictive factor of distant recurrence after pathological complete response to neoadjuvant chemotherapy in patients with large operable or locally advanced breast cancers:a sub-study of EORTC 10994/BIG1-00 phase III trial[J].Eur J Cancer,2015,51(3):301-309.
[25]WU Q,LI J,SUN S,et al.Thermal tomography for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer[J].Oncotarget,2017,8(40):68974-68983.
[26]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2017年版)[J].中国癌症杂志,2017,27(9):695-759.Chinese Anti-Cancer Association,Committee of Breast Cancer Society.China anti-cancer association breast cancer diagnosis and treatment guidelines and regulations(2017 edition)[J].China Oncology,2017,27(9):695-759.
[27]霍慧萍,霍建彬,万文博,等.三阴性裸鼠乳腺癌模型的构建及热层析检测[J].中国医学科学院学报,2016,38(2):198-204.HUO H P,HUO J B,WAN W B,et al.Construction of nude mouse model of triple negative breast cancer and value of thermal tomography[J].Acta Academiae Medicinae Sinicae,2016,38(2):198-204.