建立肛瘘模型的动物选择与常用造模方法分析
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摘要
文章对历年来研究者常用的集中建立肛瘘模型的动物不同的特点、造模方法等内容作以综述。应用计算机检索1950年1月至2017年11月期间PUBMED的相关文章,共收集到22篇相关文献,对符合纳入标准的12篇文献进行分类整理并作为文章参考文献。对常用肛瘘动物模型特点、造模方法的优点与劣势进行总结分析,认为大鼠与兔肛瘘模型在未来肛瘘术后创面愈合模型选择中有极大优势。
This article reviews the different characteristics and methods of anal fistula models which have been commonly used by researchers in the past years. A total of 22 relevant articles were collected from PUBMED during 1950-1/2017-11. Twelve documents that met the inclusion criteria were classified and sorted out as references in this paper. Animals as models should be able to accurately reflect the pathogenesis and healing process of human anal fistula. The characteristics of anal fistula models which have been commonly used, the advantages and disadvantages of common experimental animals anal modeling methods were summarized and analyzed. It is concluded that rat and rabbit models of anal fistula have great advantages in the selection of future models of wound healing after anal fistula operation.
This article reviews the different characteristics and methods of anal fistula models which have been commonly used by researchers in the past years. A total of 22 relevant articles were collected from PUBMED during 1950-1/2017-11. Twelve documents that met the inclusion criteria were classified and sorted out as references in this paper. Animals as models should be able to accurately reflect the pathogenesis and healing process of human anal fistula. The characteristics of anal fistula models which have been commonly used, the advantages and disadvantages of common experimental animals anal modeling methods were summarized and analyzed. It is concluded that rat and rabbit models of anal fistula have great advantages in the selection of future models of wound healing after anal fistula operation.
引文
[1]Mccoll I.The comparative anatomy and pathology of anal glands.Ann R Coll Surg Engl,1967,40(1):36-37
[2]Parks A G,Stitz R W.The treatment of high fistula-in-ano.Dis Colon Rectum,1976,19:487-499
[3]郑丽华,石玉迎,贾兰斯,等.应用虚实结合挂线法与传统实挂线法治疗高位肛瘘的临床观察.中华中医药杂志,2017,32(2):587-590
[4]Rosen D R,Kaiser A M.Definitive seton management for transsphincteric fistula-in-ano:Harm or charm?.Colorectal Dis,2016,18:488-495
[5]Jon D Vogel,Eric K Johnson,Arden M Morris,et al.Clinical PracticeGuidelinefortheManagementofAnorectal Abscess, Fistula-in-Ano,and Rectovaginal Fistula.Dis Colon Rectum,2016,59:1117-1133
[6]Mariana S A,Carlos H,M Gustavo R F,et al.Experimental model of anal fistula in rats.Coloproctol,2013,33(3):135-138
[7]王琛,曹永清,郭修田,等.体表瘘管大鼠模型的建立.上海中医药大学学报,2007,21(6):62-65
[8]付小兵,王德文.创伤修复基础.北京:人民军医出版社,1997:184-201
[9]张雅明,叶伟成,杨巍,等.痔科熏洗方对大鼠术后伤口愈合的实验研究.中国肛肠病杂志,2000,20(3):3-5
[10]郑雪平,许慧琴,丁义江,等.复方珠黄霜对兔背部人粪污染创面愈合的实验研究.中国中西医结合外科杂志,2002,8(5):361-363
[11]朱群.肛门部手术创面迟缓愈合原因分析及对策.南京中医药大学学报,1997,13(3):167-168
[12]Harvey C E.Perianal fistula in the dog.Vet Rec,1972,91(2):25-33
[13]Greiner T P.Surgical treatment of canine perianal fistulas 76:663-4.Vet Med Small Anim Clin,1981,76:663-664
[14]孙琳,王燕霞,陈晋杰,等.肛门括约肌在肛瘘形成及治疗中的作用.北京医学,1995,17(6):326-328
[15]Buchanan G N,Sibbons P,Osborn M,et al.Experimental model of fistula-in-ano.Dis Colon Rectum,2015,48:353-358
[16]J G Han,H M Xu,W L Song,et al.Histologic analysis of acellular dermal matrix in the treatment of anal fistula in an animal model.J Am Coll Surg,2009,208(6):1099-1106
[17]Masayasu A,Mitsuo M,Katsuya O,et al.A newly designed anal fistula plug:Clinico-pathological study in an experimental iatrogenic fistula model.Int Surg,2013,98:122-128
[18]MMTJ A,H Chen,X Liu,et al.Experimental porcine model of complex fistula-in-ano.World J Gastroenterol,2017,23(10):1828-1835
[2]Parks A G,Stitz R W.The treatment of high fistula-in-ano.Dis Colon Rectum,1976,19:487-499
[3]郑丽华,石玉迎,贾兰斯,等.应用虚实结合挂线法与传统实挂线法治疗高位肛瘘的临床观察.中华中医药杂志,2017,32(2):587-590
[4]Rosen D R,Kaiser A M.Definitive seton management for transsphincteric fistula-in-ano:Harm or charm?.Colorectal Dis,2016,18:488-495
[5]Jon D Vogel,Eric K Johnson,Arden M Morris,et al.Clinical PracticeGuidelinefortheManagementofAnorectal Abscess, Fistula-in-Ano,and Rectovaginal Fistula.Dis Colon Rectum,2016,59:1117-1133
[6]Mariana S A,Carlos H,M Gustavo R F,et al.Experimental model of anal fistula in rats.Coloproctol,2013,33(3):135-138
[7]王琛,曹永清,郭修田,等.体表瘘管大鼠模型的建立.上海中医药大学学报,2007,21(6):62-65
[8]付小兵,王德文.创伤修复基础.北京:人民军医出版社,1997:184-201
[9]张雅明,叶伟成,杨巍,等.痔科熏洗方对大鼠术后伤口愈合的实验研究.中国肛肠病杂志,2000,20(3):3-5
[10]郑雪平,许慧琴,丁义江,等.复方珠黄霜对兔背部人粪污染创面愈合的实验研究.中国中西医结合外科杂志,2002,8(5):361-363
[11]朱群.肛门部手术创面迟缓愈合原因分析及对策.南京中医药大学学报,1997,13(3):167-168
[12]Harvey C E.Perianal fistula in the dog.Vet Rec,1972,91(2):25-33
[13]Greiner T P.Surgical treatment of canine perianal fistulas 76:663-4.Vet Med Small Anim Clin,1981,76:663-664
[14]孙琳,王燕霞,陈晋杰,等.肛门括约肌在肛瘘形成及治疗中的作用.北京医学,1995,17(6):326-328
[15]Buchanan G N,Sibbons P,Osborn M,et al.Experimental model of fistula-in-ano.Dis Colon Rectum,2015,48:353-358
[16]J G Han,H M Xu,W L Song,et al.Histologic analysis of acellular dermal matrix in the treatment of anal fistula in an animal model.J Am Coll Surg,2009,208(6):1099-1106
[17]Masayasu A,Mitsuo M,Katsuya O,et al.A newly designed anal fistula plug:Clinico-pathological study in an experimental iatrogenic fistula model.Int Surg,2013,98:122-128
[18]MMTJ A,H Chen,X Liu,et al.Experimental porcine model of complex fistula-in-ano.World J Gastroenterol,2017,23(10):1828-1835