青年宫颈癌与中老年宫颈癌临床病理特征对比分析
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摘要
目的对比分析青年宫颈癌与中老年宫颈癌的临床病理特征。方法选取2017年1月～2018年6月间我院收治的138例宫颈癌患者,根据患者发病年龄将其分为青年组(年龄<40岁,n=75)与中老年组(年龄≥40岁,n=63),采取回顾性分析的方法对两组临床表现与病理特征资料进行对比分析。结果青年组临床表现以接触性出血(65.33%)、白带异常(65.33%)为主,中老年组临床表现则以不规则出血(63.40%)为主,差异有统计学意义(P <0.05)。在病理特征方面,青年组局部淋巴结转移(62.67%)、远处脏器转移(25.33%)、腺癌(22.67%)患者占比均明显高于中老年组,差异有统计学意义(P <0.05),而中老年组鳞状细胞(95.24%)患者占比则明显高于青年组,差异有统计学意义(P <0.05)。青年组高危型HPV感染率明显高于中老年组,差异有统计学意义(P <0.05)。病理类型不同时青年组与中老年组随访期内生存率差异无统计学意义(P> 0.05)。结论青年宫颈癌与中老年宫颈癌的临床表现与病理特征均存在差异,需要加强对疑似病理的临床病理特征观察,及早确诊,提高宫颈癌临床诊断率,为疾病治疗创造有利条件。
Objective To compare and analyze the clinicopathological features of cervical cancer in young and middle-aged and elderly patients. Methods One hundred and thirty-eight cases of cervical cancer patients in our hospital from January 2017 to June 2018 were divided into young group(age < 40 years,n=75)and middleaged and elderly group(age ≥ 40 years,n=63).The retrospective analysis method was used to compare the clinical and pathological features of the two groups. Results The clinical manifestations of the youth group were mainly contact bleeding(65.33%)and abnormal leucorrhea(65.33%),while clinical manifestations of the middle-aged and elderly group were mainly irregular bleeding(63.40%).The difference in clinical manifestations between the two groups was statistically significant(P < 0.05).In the pathological features,the proportion of local lymph node metastasis(62.67%),distant visceral metastasis(25.33%)and adenocarcinoma(22.67%)in the young group were significantly higher than that in the middle-aged and elderly group(P < 0.05),while the proportion of the squamous cell(95.24%)patients in the middle-aged and elderly group was significantly higher than that in the young group.There were statistical significance(P < 0.05).The infection rate of high-risk HPV in the youth group was significantly higher than that in the middle-aged and elderly group,and the difference was statistically significant(P < 0.05).There was no significant difference in the survival rate between the young group and the middle-aged and elderly group during the follow-up period(P > 0.05). Conclusion There are differences in the clinical manifestations and pathological characteristics between young cervical cancer and middle-aged and elderly patients with cervical cancer.It is necessary to strengthen the observation of clinicopathological characteristics of suspected pathology,make early diagnosis,improve the clinical diagnosis rate of cervical cancer,and create favorable conditions for disease treatment.
Objective To compare and analyze the clinicopathological features of cervical cancer in young and middle-aged and elderly patients. Methods One hundred and thirty-eight cases of cervical cancer patients in our hospital from January 2017 to June 2018 were divided into young group(age < 40 years,n=75)and middleaged and elderly group(age ≥ 40 years,n=63).The retrospective analysis method was used to compare the clinical and pathological features of the two groups. Results The clinical manifestations of the youth group were mainly contact bleeding(65.33%)and abnormal leucorrhea(65.33%),while clinical manifestations of the middle-aged and elderly group were mainly irregular bleeding(63.40%).The difference in clinical manifestations between the two groups was statistically significant(P < 0.05).In the pathological features,the proportion of local lymph node metastasis(62.67%),distant visceral metastasis(25.33%)and adenocarcinoma(22.67%)in the young group were significantly higher than that in the middle-aged and elderly group(P < 0.05),while the proportion of the squamous cell(95.24%)patients in the middle-aged and elderly group was significantly higher than that in the young group.There were statistical significance(P < 0.05).The infection rate of high-risk HPV in the youth group was significantly higher than that in the middle-aged and elderly group,and the difference was statistically significant(P < 0.05).There was no significant difference in the survival rate between the young group and the middle-aged and elderly group during the follow-up period(P > 0.05). Conclusion There are differences in the clinical manifestations and pathological characteristics between young cervical cancer and middle-aged and elderly patients with cervical cancer.It is necessary to strengthen the observation of clinicopathological characteristics of suspected pathology,make early diagnosis,improve the clinical diagnosis rate of cervical cancer,and create favorable conditions for disease treatment.
引文
[1]吴小容,杨文静.青年宫颈癌和中老年宫颈癌患者临床症状与病理特征分析[J].临床医学工程,2016,23(11):1491-1492.
[2]张云霞,那仁花,古丽娜·库尔班.人乳头瘤病毒亚型与宫颈癌及癌前病变发生及预后的相关性分析[J].中国妇幼保健,2015,30(15):2319-2322.
[3]张锁平,廉航.82例宫颈癌患者的临床病理特点探究[J].临床医学研究与实践,2017,2(18):88-89.
[4]吴建锋.年轻宫颈癌患者的病理特征及危险因素分析[J].系统医学,2017,2(13):7-8.
[5]龙颖,姚德生,韦有生.嗜神经侵袭与早期宫颈癌临床病理特征及预后的关系[J].临床肿瘤学杂志,2017,22(8):712-717.
[6]张月,尚莉莉,陈荣青,等.绝经前后妇女宫颈癌的临床病理对比分析[J].中国民康医学,2015,27(3):38-40.
[7]王晓,李华.青年与中老年宫颈癌的临床病理特征对比[J].中国医药指南,2015,13(18):93-94.
[8]欧阳俊,彭久君.分析青年与中老年宫颈癌的临床病理特征[J].实用妇科内分泌电子杂志,2015,2(7):151,153.
[9]林棠英.青年妇女发生宫颈癌的因素及预后研究[J].中国妇幼保健,2016,31(16):3218-3220.
[10]谭国柱,王秀娟.老年宫颈癌患者的临床病理特点及预后分析[J].实用癌症杂志,2014,29(1):66-67.
[11]谢林利,王彬,闫田静,等.35岁以下年轻宫颈癌患者的临床病理特征以及危险因素分析[J].中国妇幼保健,2016,31(20):4147-4148.
[12]孙晓东,刘敏,鲍慧,等.不同年龄段宫颈癌患者的病理特点及预后分析[J].现代肿瘤医学,2018,26(11):1766-1769.
[13]刘伏香,谭志琴,龙丹,等.青年妇女患宫颈癌的临床特点及预后分析[J].现代生物医学进展,2014,14(9):1676-1679.
[14]赵国宏.青年宫颈癌与中老年宫颈癌临床病理特征对比探究[J].中国卫生产业,2014,11(24):150-151.
[15]赵莹,周训华,陈艳辉.宫颈上皮细胞稳定性游离亚铁原卟啉检测在不同年龄段宫颈癌诊断中的意义[J].中国医药导报,2018,39(6):110-113.
[16]杨丽娟.不同年龄段宫颈癌临床与病理特点分析[J].医学理论与实践,2015,28(7):863-864.
[2]张云霞,那仁花,古丽娜·库尔班.人乳头瘤病毒亚型与宫颈癌及癌前病变发生及预后的相关性分析[J].中国妇幼保健,2015,30(15):2319-2322.
[3]张锁平,廉航.82例宫颈癌患者的临床病理特点探究[J].临床医学研究与实践,2017,2(18):88-89.
[4]吴建锋.年轻宫颈癌患者的病理特征及危险因素分析[J].系统医学,2017,2(13):7-8.
[5]龙颖,姚德生,韦有生.嗜神经侵袭与早期宫颈癌临床病理特征及预后的关系[J].临床肿瘤学杂志,2017,22(8):712-717.
[6]张月,尚莉莉,陈荣青,等.绝经前后妇女宫颈癌的临床病理对比分析[J].中国民康医学,2015,27(3):38-40.
[7]王晓,李华.青年与中老年宫颈癌的临床病理特征对比[J].中国医药指南,2015,13(18):93-94.
[8]欧阳俊,彭久君.分析青年与中老年宫颈癌的临床病理特征[J].实用妇科内分泌电子杂志,2015,2(7):151,153.
[9]林棠英.青年妇女发生宫颈癌的因素及预后研究[J].中国妇幼保健,2016,31(16):3218-3220.
[10]谭国柱,王秀娟.老年宫颈癌患者的临床病理特点及预后分析[J].实用癌症杂志,2014,29(1):66-67.
[11]谢林利,王彬,闫田静,等.35岁以下年轻宫颈癌患者的临床病理特征以及危险因素分析[J].中国妇幼保健,2016,31(20):4147-4148.
[12]孙晓东,刘敏,鲍慧,等.不同年龄段宫颈癌患者的病理特点及预后分析[J].现代肿瘤医学,2018,26(11):1766-1769.
[13]刘伏香,谭志琴,龙丹,等.青年妇女患宫颈癌的临床特点及预后分析[J].现代生物医学进展,2014,14(9):1676-1679.
[14]赵国宏.青年宫颈癌与中老年宫颈癌临床病理特征对比探究[J].中国卫生产业,2014,11(24):150-151.
[15]赵莹,周训华,陈艳辉.宫颈上皮细胞稳定性游离亚铁原卟啉检测在不同年龄段宫颈癌诊断中的意义[J].中国医药导报,2018,39(6):110-113.
[16]杨丽娟.不同年龄段宫颈癌临床与病理特点分析[J].医学理论与实践,2015,28(7):863-864.