血清雌三醇的生化与临床应用进展
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摘要
血清雌三醇为妊娠期的主要雌激素,能直接反映胎儿-胎盘功能及胎儿宫内发育情况。在妊娠中晚期,胎儿和孕妇易受高危因素的影响而发生产科并发症,为了降低围生儿病死率和提高高危妊娠的诊断率,动态监测血清雌三醇水平有重要的临床价值。本文就血清雌三醇的结构及分泌、生物学功能、检测方法与临床应用的研究做一综述。
Serum estriol is the main estrogen during gestation period, it can direct response fetal-placental function and fetal intrauterine development situation. In the middle-late pregnancy, the fetal and pregnant women are vulnerable to the influence of risk factors and produce obstetric complications. In order to reduce the dead mortality of perinatal infants and improve the diagnosis rate of high-risk pregnancy, the dynamic monitoring of serum estriol level has important clinical value. In this article the structure and secretion, biological function, detection method and clinical application of estriol are introduced.
Serum estriol is the main estrogen during gestation period, it can direct response fetal-placental function and fetal intrauterine development situation. In the middle-late pregnancy, the fetal and pregnant women are vulnerable to the influence of risk factors and produce obstetric complications. In order to reduce the dead mortality of perinatal infants and improve the diagnosis rate of high-risk pregnancy, the dynamic monitoring of serum estriol level has important clinical value. In this article the structure and secretion, biological function, detection method and clinical application of estriol are introduced.
引文
[1]白莲莲.联合检测人绒毛膜促性腺激素、游离雌三醇在妊娠晚期监测胎盘功能的临床价值[J].实用医技杂志,2012,19(1):38-39.
[2]莫伟.血中游离雌三醇水平测定在产前检查中的应用[J].黑龙江医学,2005,29(3):204.
[3]洪建琴,曾云,陈敏,等.妊娠中晚期测定血清CG和E3的临床意义[J].放射免疫学杂志,2010,23(5):509-510.
[4]Farina A,Sekizawa A,Purwosunu Y,et al.Quantitative distribution of a panel of circulating m RNA in preeclampsia versus controls[J].Prenat Diagn,2006,26(12):1115-1120.
[5]Lee NM,Brady CM.Live disease in pregnancy[J].Word J Gastroenterol,2009,15(8):897-906.
[6]朱庆文,周君.血清游离雌三醇和胎盘催乳素联合测定在孕产妇监护中的意义[J].标记免疫分析与临床,2011,18(2):74-76.
[7]刘爱胜,陈荣贵,文艳.中期孕妇血清中AFP、FE3、游离β-HCG检测的临床意义及影响因素分析[J].国际检验医学杂志,2011,32(18):2059-2060.
[8]王昕,朱其荪,贾盛芳.孕妇血清FE3RIA在产前监护中的应用[J].放射免疫学杂志,2005,18(3):209.
[9]彭杨水,李格芳,陈筠虹.羊水游离雌三醇测定胎儿胎盘功能[J].放射免疫学杂志,2005,18(3):202.
[10]李苏娅,孙定河.3065例妊娠晚期血清游离雌三醇(u E3)的检测分析及临床价值的探讨[J].中国优生与遗传杂志,2007,15(3):42,47.
[11]韩连菊,邵岚,张蕾,等.血清β-HCG、AFP、u E3与妊娠期并发高血压与糖尿病的相关性及对分娩结局的影响[J].临床合理用药,2014,7(11A):112-113.
[12]蔡霞,乔拉,耿丽红,等.妊娠高血压综合征胎盘细胞凋亡的研究[J].新疆医科大学学报,2003,26(5):462.
[13]Allaire AD,Ballenger KA,Wells SR,et al.Placental apoptosis in preeclampsia[J].Obstet Gynecol,2000,96(2):271-276.
[14]金克勤,吴远桥.394例正常高危妊娠孕妇血清游离雌三醇(FE3)的观察[J].中国优生优育,2010,16(6):316-317.
[15]张宝牛,高桂珠,丁明辉,等.联合检测孕妇血清雌三醇和胎盘泌乳素监测胎盘功能[J].临床医药实践杂志,2009,18(1):19-20.
[16]张建平,刘玉昆,李海刚,等.胎儿宫内生长迟缓患者的胎盘免疫病理学观察[J].中华妇产科杂志,2001,36(4):202.
[17]Geenes V,Williamson C.Intrahepatic cholestasis of pregnancy[J].World J Gastroenterol,2009,15(17):2049-2066.
[18]卢帅军,厉倩,朱长玲,等.妊娠母体血清h PL、u E3水平与子痫前期的关系[J].国际检验医学杂志,2012,33(13):1574-1575.
[19]丰友吉,沈铿.妇产科学[M].2版.北京:人民卫生出版社,2011:92.
[20]郭晓春,何庆才.118例过期妊娠结局与胎盘成熟度的关系[J].西部医学,2009,21(1):36-38.
[21]张淑莉,齐洪伟.母血FE3、HPL检测胎盘功能对慢性胎儿宫内窘迫诊断价值的研究[J].中国实用医药,2013,8(8):6-7.
[22]詹洪晶.妊娠期糖尿病患者妊娠结局32例临床分析[J].中国现代医生,2013,51(29):131-132.
[23]于彩霞,王会芳,胡哲英.探讨血清雌三醇和人胎盘催乳素水平与高危妊娠的关系[J].解放军医学院学报,2014,35(2):150-152.
[24]张娜,李靖,高志民.胎盘功能测定在围产期的应用[J].实用医技杂志,2008,15(31):4419-4420.
[25]李永红.妊娠期高血压综合征对妊娠结局的影响[J].中国医药指南,2012,10(9):462-463.
[26]庞伟斌,王红武,付妮娜,等.189例孕妇血清雌三醇和胎盘泌乳素测定监测胎盘功能分析[J].吉林医学,2012,33(23):4951-4952.
[27]朱丽亚,张凤.胎盘Ⅲ级与新生儿评分的影响[J].中国临床研究,2011,3(24):111.
[28]张淑莉,齐洪伟.对高危妊娠孕妇血清雌三醇和胎盘泌乳素检测的研究[J].中国现代药物应用,2011,5(14):16-17.
[29]王铮,黄国香,杨柳,等.孕中期血清学产前筛查的临床意义分析[J].国际检验医学杂志,2013,34(12):1545-1548.
[30]周希亚,戚庆炜,蒋宇林,等.高龄孕妇胎儿唐氏综合征中孕期产前筛查和产前诊断的卫生经济学分析[J].生殖医学杂志,2012,21(2):209-213.
[31]Wald NJ,Cuckle HS,Densem JW.Maternal serum screening for Down's syndrome in early pregnancy[J].Br Med J,2010,297(36):35-38.
[32]Androutsopoulos G,Gkogkos P,Decavalas G.Mid-trimester maternal serum HCG and alpha fetal protein levels:clinical significance and prediction of adversepregnancy outcome[J].Int J Endocrinol Metab,2013,11:102-106.
[33]冯翠琴,孟媛.B超诊断羊水过少240例临床分析[J].医学理论与实践,2013,26(16):2193-2194.
[2]莫伟.血中游离雌三醇水平测定在产前检查中的应用[J].黑龙江医学,2005,29(3):204.
[3]洪建琴,曾云,陈敏,等.妊娠中晚期测定血清CG和E3的临床意义[J].放射免疫学杂志,2010,23(5):509-510.
[4]Farina A,Sekizawa A,Purwosunu Y,et al.Quantitative distribution of a panel of circulating m RNA in preeclampsia versus controls[J].Prenat Diagn,2006,26(12):1115-1120.
[5]Lee NM,Brady CM.Live disease in pregnancy[J].Word J Gastroenterol,2009,15(8):897-906.
[6]朱庆文,周君.血清游离雌三醇和胎盘催乳素联合测定在孕产妇监护中的意义[J].标记免疫分析与临床,2011,18(2):74-76.
[7]刘爱胜,陈荣贵,文艳.中期孕妇血清中AFP、FE3、游离β-HCG检测的临床意义及影响因素分析[J].国际检验医学杂志,2011,32(18):2059-2060.
[8]王昕,朱其荪,贾盛芳.孕妇血清FE3RIA在产前监护中的应用[J].放射免疫学杂志,2005,18(3):209.
[9]彭杨水,李格芳,陈筠虹.羊水游离雌三醇测定胎儿胎盘功能[J].放射免疫学杂志,2005,18(3):202.
[10]李苏娅,孙定河.3065例妊娠晚期血清游离雌三醇(u E3)的检测分析及临床价值的探讨[J].中国优生与遗传杂志,2007,15(3):42,47.
[11]韩连菊,邵岚,张蕾,等.血清β-HCG、AFP、u E3与妊娠期并发高血压与糖尿病的相关性及对分娩结局的影响[J].临床合理用药,2014,7(11A):112-113.
[12]蔡霞,乔拉,耿丽红,等.妊娠高血压综合征胎盘细胞凋亡的研究[J].新疆医科大学学报,2003,26(5):462.
[13]Allaire AD,Ballenger KA,Wells SR,et al.Placental apoptosis in preeclampsia[J].Obstet Gynecol,2000,96(2):271-276.
[14]金克勤,吴远桥.394例正常高危妊娠孕妇血清游离雌三醇(FE3)的观察[J].中国优生优育,2010,16(6):316-317.
[15]张宝牛,高桂珠,丁明辉,等.联合检测孕妇血清雌三醇和胎盘泌乳素监测胎盘功能[J].临床医药实践杂志,2009,18(1):19-20.
[16]张建平,刘玉昆,李海刚,等.胎儿宫内生长迟缓患者的胎盘免疫病理学观察[J].中华妇产科杂志,2001,36(4):202.
[17]Geenes V,Williamson C.Intrahepatic cholestasis of pregnancy[J].World J Gastroenterol,2009,15(17):2049-2066.
[18]卢帅军,厉倩,朱长玲,等.妊娠母体血清h PL、u E3水平与子痫前期的关系[J].国际检验医学杂志,2012,33(13):1574-1575.
[19]丰友吉,沈铿.妇产科学[M].2版.北京:人民卫生出版社,2011:92.
[20]郭晓春,何庆才.118例过期妊娠结局与胎盘成熟度的关系[J].西部医学,2009,21(1):36-38.
[21]张淑莉,齐洪伟.母血FE3、HPL检测胎盘功能对慢性胎儿宫内窘迫诊断价值的研究[J].中国实用医药,2013,8(8):6-7.
[22]詹洪晶.妊娠期糖尿病患者妊娠结局32例临床分析[J].中国现代医生,2013,51(29):131-132.
[23]于彩霞,王会芳,胡哲英.探讨血清雌三醇和人胎盘催乳素水平与高危妊娠的关系[J].解放军医学院学报,2014,35(2):150-152.
[24]张娜,李靖,高志民.胎盘功能测定在围产期的应用[J].实用医技杂志,2008,15(31):4419-4420.
[25]李永红.妊娠期高血压综合征对妊娠结局的影响[J].中国医药指南,2012,10(9):462-463.
[26]庞伟斌,王红武,付妮娜,等.189例孕妇血清雌三醇和胎盘泌乳素测定监测胎盘功能分析[J].吉林医学,2012,33(23):4951-4952.
[27]朱丽亚,张凤.胎盘Ⅲ级与新生儿评分的影响[J].中国临床研究,2011,3(24):111.
[28]张淑莉,齐洪伟.对高危妊娠孕妇血清雌三醇和胎盘泌乳素检测的研究[J].中国现代药物应用,2011,5(14):16-17.
[29]王铮,黄国香,杨柳,等.孕中期血清学产前筛查的临床意义分析[J].国际检验医学杂志,2013,34(12):1545-1548.
[30]周希亚,戚庆炜,蒋宇林,等.高龄孕妇胎儿唐氏综合征中孕期产前筛查和产前诊断的卫生经济学分析[J].生殖医学杂志,2012,21(2):209-213.
[31]Wald NJ,Cuckle HS,Densem JW.Maternal serum screening for Down's syndrome in early pregnancy[J].Br Med J,2010,297(36):35-38.
[32]Androutsopoulos G,Gkogkos P,Decavalas G.Mid-trimester maternal serum HCG and alpha fetal protein levels:clinical significance and prediction of adversepregnancy outcome[J].Int J Endocrinol Metab,2013,11:102-106.
[33]冯翠琴,孟媛.B超诊断羊水过少240例临床分析[J].医学理论与实践,2013,26(16):2193-2194.