游离雌三醇和人胎盘催乳素测定在子痫前期的意义
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摘要
目的探讨血清游离雌三醇(uE3)和人胎盘催乳素(hPL)与子痫前期的关系。方法选取2013年6月至2014年6月诊断为子痫前期的孕妇123例纳入观察组,同期健康孕妇150例纳入对照组,两组孕妇均分别在妊娠28~<32周和妊娠32~36周各采血一次,检测血清uE3和hPL水平并进行比较。结果对照组妊娠结局优于观察组。随着孕周增加两组孕妇血清uE3和hPL水平有升高趋势,在相同孕期中对照组血清uE3和hPL水平均较观察组高,差异均有统计学意义(P<0.05)。结论子痫前期孕妇血清uE3和hPL水平下降,与妊娠结局相关。
Objective To explore the relationship between serum levels of unconjugated estriol(uE3)and human placental lactogen(hPL)and preeclampsia.Methods 123 cases of pregnant women diagnosed as preeclampsia were enrolled into observational group,and 150 cases of healthy pregnant women were enrolled into control group.Blood specimen were collected from the two groups in 28-<32gestational weeks and 32-36 gestational weeks.Serum levels of uE3 and hPL were determined and compared between the two groups.Results The pregnancy outcomes of the control group were better than those of the observation group.With the increase of gestational age,there was increasing trend of serum levels of uE3 and hPL in the two groups.However,compared with the observation group,the serum levels of uE3 and hPL were higher in the control group,and the differences were statistically significant(P<0.05).Conclusion The decrease of serum levels of uE3 and hPL in pregnant women with preeclampsia may be associated with the pregnancy outcomes.
Objective To explore the relationship between serum levels of unconjugated estriol(uE3)and human placental lactogen(hPL)and preeclampsia.Methods 123 cases of pregnant women diagnosed as preeclampsia were enrolled into observational group,and 150 cases of healthy pregnant women were enrolled into control group.Blood specimen were collected from the two groups in 28-<32gestational weeks and 32-36 gestational weeks.Serum levels of uE3 and hPL were determined and compared between the two groups.Results The pregnancy outcomes of the control group were better than those of the observation group.With the increase of gestational age,there was increasing trend of serum levels of uE3 and hPL in the two groups.However,compared with the observation group,the serum levels of uE3 and hPL were higher in the control group,and the differences were statistically significant(P<0.05).Conclusion The decrease of serum levels of uE3 and hPL in pregnant women with preeclampsia may be associated with the pregnancy outcomes.
引文
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[9]孙雯,陈敦金.胎盘功能与子痫前期的研究进展[J/CD].中华产科急救电子杂志,2013,2(1):51-54.
[2]Dutton PJ,Warrander LK,Roberts SA,et al.Predictors of poor perinatal outcome following maternal perception of reduced fetal movements:aprospective cohort study[J].PLoS One,2012,7(7):e39784,
[3]Lambert G,Brichant JF,Hartstein G,et al.Preeclampsia:an update[J].Acta Anaesthesiol Belg,2014,65(4):137-149.
[4]陶俊.绒毛外滋养细胞与螺旋动脉重铸及子痫前期[J].国际妇产科学杂志,2011,38(3):174-177.
[5]谢幸,苟文丽.妇产科学[M].北京:人民卫生出版社,2013:64-71.
[6]Huang T,Hoffman B,Meschino W,et al.Prediction of adverse pregnancy outcomes by combinations of first and second trimester biochemistry markers used in the routine prenatal screening of Down syndrome[J].Prenat Diagn,2010,30(5):471-477.
[7]Jelliffe-Pawlowski LL,Baer RJ,Currier RJ.Second trimester serum predictors of preterm birth in a population-based sample of low-risk pregnancies[J].Prenat Diagn,2010,30(8):727-733.
[8]周倩,胡晓雨,蒋宇林,等.妊娠中期唐氏综合征筛查血清标志物异常与不良妊娠结局[J].中华围产医学杂志,2013,16(9):555-560.
[9]孙雯,陈敦金.胎盘功能与子痫前期的研究进展[J/CD].中华产科急救电子杂志,2013,2(1):51-54.