超声波联合扶正升血方穴位贴敷在肝硬化脾功能亢进患者中的应用
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摘要
目的:探讨超声波联合扶正升血方穴位贴敷对肝硬化脾功能亢进患者白细胞、红细胞、血小板的影响及不良反应。方法:将65例入组患者,随机分为两组,对照组予利可君口服,疗程4周;治疗组在对照组治疗的基础上,加用超声波联合扶正升血方穴位贴敷。两组均检测治疗前后患者白细胞、红细胞、血小板水平,观察症状改善情况。结果:治疗组总有效率达84.37%,对照组总有效率达48.48%,差异具有统计学意义(P <0.05);治疗组治疗前后症状积分有统计学意义(P <0.05),对照组治疗前后症状积分无统计学意义。结论:超声波联合扶正升血方穴位贴敷对肝硬化脾功能亢进具有良好的疗效,无明显不良反应。
To explore the effects on white blood cells(WBC), red blood cells(RBC) and platelets(PLT) as well as adverse reactions of ultrasonic combined with Fuzhengshengxue Decoction acupoint application in the patients with liver cirrhosis and hypersplenism. A total of 65 patients were enrolled and randomly divided into 2 groups. The control group was given oral leucogen for 4 weeks. Based on the treatment of the control group, the treatment group was additionally given ultrasonic combined with Fuzhengshengxue Decoction acupoint application. The WBC, RBC, PLT levels were tested before and after treatment. Symptom changes were observed. The total effective rate of the treatment group was 84.37%,while that of the control group was 48.48%, in which the difference was statistically significant(P < 0.05). The symptom scores of the treatment group before and after treatment were statistically significant(P < 0.05), while those of the control group were not statistically significant. Therefore, ultrasonic combined with Fuzhengshengxue Decoction acupoint application for liver cirrhosis and hypersplenism has good curative effect, without obvious adverse reaction.
To explore the effects on white blood cells(WBC), red blood cells(RBC) and platelets(PLT) as well as adverse reactions of ultrasonic combined with Fuzhengshengxue Decoction acupoint application in the patients with liver cirrhosis and hypersplenism. A total of 65 patients were enrolled and randomly divided into 2 groups. The control group was given oral leucogen for 4 weeks. Based on the treatment of the control group, the treatment group was additionally given ultrasonic combined with Fuzhengshengxue Decoction acupoint application. The WBC, RBC, PLT levels were tested before and after treatment. Symptom changes were observed. The total effective rate of the treatment group was 84.37%,while that of the control group was 48.48%, in which the difference was statistically significant(P < 0.05). The symptom scores of the treatment group before and after treatment were statistically significant(P < 0.05), while those of the control group were not statistically significant. Therefore, ultrasonic combined with Fuzhengshengxue Decoction acupoint application for liver cirrhosis and hypersplenism has good curative effect, without obvious adverse reaction.
引文
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2梁彦,伊文静,贾战生,等.肝硬化患者脾功能亢进治疗研究进展.临床肝胆病杂志,2015,31(11):1924-1927.
3吕行,陈勇.肝炎后肝硬化所致脾功能亢进临床研究进展.中华肝胆外科杂志,2016,22(9):642-645.
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5郑筱萸.中药新药临床研究指导原则.北京:中国医药科技出版社,2002:173-177.
6瞿茹莼.腹部超声检查在肝硬化疾病病因诊断中的临床应用价值研究.山西医药杂志,2015,44(20):2383-2385.
7王育慷.超声波原理与现代应用探讨.贵州大学学报:自然科学版,2005,22(3):287-290.
8朱良春.朱良春医集.长沙:中南大学出版社,2007:383.
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11王东晓,陈孟莉,殷建芬,等.鸡血藤活性成分SS8对骨髓抑制小鼠造血祖细胞增殖的作用.中国中药杂志,2003,28(2):152-155.
12张晓君,祝晨藤,胡黎,等.党参多糖对小鼠免疫和造血功能的影响.中药新药与临床药理二十周年刊庆祝大会暨世中联中药药理专业委员会学术年会,2011.
13张天红,张馨,耿爱萍.潞党参药理实验研究.时珍国医国药,2001,12(6):488.
14高丽松,曾凡潘,宁榴贤,等.磁处理党参药液对小鼠血液生理功能影响的研究.生物磁学,2005,5(1):14.
15毛宇,徐芳,邹云,等.当归多糖对造血功能的影响及其机制的研究.食品研究与开发,2015(8):122-126.
16 Hwa J S,Jin Y C,Lee Y S,et al.2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction.J Ethnopharmacol,2012,139(2):605-615.
17周光平.神阙穴临床应用探析.中医临床研究,2017,9(9):103-105.
18施茵,吴焕淦.足三里穴在免疫功能调节中的应用.现代中医药,2003(3):3-6.
19苏彩云,庞红霞,陈婉花.足三里穴位注射地塞米松对骨髓抑制患者白细胞吞噬功能影响的临床观察.中外医疗,2008,27(23):48.
20吴建军,戚玲娟.针灸足三里治疗乳腺癌放化疗后白细胞减少21例.浙江中医杂志,2008,43(1):46.
21赵立明,赵光毅.穴位注射治疗白细胞减少症41例.中国针灸,2002,22(5):342-342.
2梁彦,伊文静,贾战生,等.肝硬化患者脾功能亢进治疗研究进展.临床肝胆病杂志,2015,31(11):1924-1927.
3吕行,陈勇.肝炎后肝硬化所致脾功能亢进临床研究进展.中华肝胆外科杂志,2016,22(9):642-645.
4钱礼.钱礼腹部外科学.北京:人民卫生出版社,2006:763-772.
5郑筱萸.中药新药临床研究指导原则.北京:中国医药科技出版社,2002:173-177.
6瞿茹莼.腹部超声检查在肝硬化疾病病因诊断中的临床应用价值研究.山西医药杂志,2015,44(20):2383-2385.
7王育慷.超声波原理与现代应用探讨.贵州大学学报:自然科学版,2005,22(3):287-290.
8朱良春.朱良春医集.长沙:中南大学出版社,2007:383.
9高学敏.中药学.北京:中国中医药出版社,2002:277.
10梁宁,韦松基,林启云,等.鸡血藤总黄酮对血虚小鼠抗贫血作用及机理研究.时珍国医国药,2009,20(2):362-363.
11王东晓,陈孟莉,殷建芬,等.鸡血藤活性成分SS8对骨髓抑制小鼠造血祖细胞增殖的作用.中国中药杂志,2003,28(2):152-155.
12张晓君,祝晨藤,胡黎,等.党参多糖对小鼠免疫和造血功能的影响.中药新药与临床药理二十周年刊庆祝大会暨世中联中药药理专业委员会学术年会,2011.
13张天红,张馨,耿爱萍.潞党参药理实验研究.时珍国医国药,2001,12(6):488.
14高丽松,曾凡潘,宁榴贤,等.磁处理党参药液对小鼠血液生理功能影响的研究.生物磁学,2005,5(1):14.
15毛宇,徐芳,邹云,等.当归多糖对造血功能的影响及其机制的研究.食品研究与开发,2015(8):122-126.
16 Hwa J S,Jin Y C,Lee Y S,et al.2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction.J Ethnopharmacol,2012,139(2):605-615.
17周光平.神阙穴临床应用探析.中医临床研究,2017,9(9):103-105.
18施茵,吴焕淦.足三里穴在免疫功能调节中的应用.现代中医药,2003(3):3-6.
19苏彩云,庞红霞,陈婉花.足三里穴位注射地塞米松对骨髓抑制患者白细胞吞噬功能影响的临床观察.中外医疗,2008,27(23):48.
20吴建军,戚玲娟.针灸足三里治疗乳腺癌放化疗后白细胞减少21例.浙江中医杂志,2008,43(1):46.
21赵立明,赵光毅.穴位注射治疗白细胞减少症41例.中国针灸,2002,22(5):342-342.