等离子体对人体组织的渗透作用:研究现状与前沿问题
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摘要
大气压冷等离子体具有取代或辅助药物用于临床治疗的巨大潜力,而人们普遍认为这是等离子体产生的活性粒子起到关键作用。活性粒子对人体组织的渗透深度决定了等离子体医学的应用范围,关系到该学科的未来研究方向,但目前学术界尚缺乏统一的认识。文中从人体组织模型、动物实验和临床试验3个层面,综述了近几年等离子体对人体组织渗透作用的研究工作,分析了等离子体产生的活性粒子在渗透过程中的物理与化学行为,并讨论了几种提高活性粒子渗透深度的方法。等离子体对人体组织的渗透作用存在诸多待解的科学问题,该综述将为相关的研究工作提供参考。
Cold atmospheric-pressure plasma has a great potential to replace or assist drugs for clinical treatment, and it is widely accepted that the plasma-generated reactive species play a crucial role. The effective penetration depth of reactive species in human tissues determines the application scope of plasma medicine, whilst it is strongly correlated to the future research direction of plasma medicine, but so far no consensus has been achieved in academia about the quantitative value of the penetration depth. In this paper, the recent researches on the penetration effect of plasma are reviewed from the viewpoints of the human tissue model, the animal experiments, and the clinical trials. The physicochemical processes of plasma-generated reactive species during their penetration are analyzed, and several approaches for enhancing the penetration depth are discussed. The penetration effect of gas plasma on human tissues has many open questions to be solved,and our review provides a reference for related research works in future.
Cold atmospheric-pressure plasma has a great potential to replace or assist drugs for clinical treatment, and it is widely accepted that the plasma-generated reactive species play a crucial role. The effective penetration depth of reactive species in human tissues determines the application scope of plasma medicine, whilst it is strongly correlated to the future research direction of plasma medicine, but so far no consensus has been achieved in academia about the quantitative value of the penetration depth. In this paper, the recent researches on the penetration effect of plasma are reviewed from the viewpoints of the human tissue model, the animal experiments, and the clinical trials. The physicochemical processes of plasma-generated reactive species during their penetration are analyzed, and several approaches for enhancing the penetration depth are discussed. The penetration effect of gas plasma on human tissues has many open questions to be solved,and our review provides a reference for related research works in future.
引文
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[9]LLOYD G,FRIEDMAN G,JAFRI S,et al.Gas plasmas:medical uses and developments in wound care[J].Plasma Processes and Polymers,2010,7(3/4):194-211.
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[11]XU G M,SHI X M,CAI J F,et al.Dual effects of atmospheric pressure plasma jet on skin wound healing of mice[J].Wound Repair&Regeneration,2016,23(6):878-884.
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[18]XIA W J,LIU D X,XU H,et al.The effect of ethanol gas impurity on the discharge mode and discharge products of argon plasma jet at atmospheric pressure[J].Plasma Sources Science and Technology,2018,27:055001.
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