NAFLD患者MR IDEAL-IQ序列下FF与TBF、BMI的相关性
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摘要
目的研究非酒精性脂肪肝(NAFLD)患者MR IDEAL-IQ序列下肝脏脂肪含量脂肪分数(FF)与体内脂肪百分比(TBF)、体质量指数(BMI)的相关性。方法纳入86例NAFLD患者为A组,另选取同期健康体检者50人为B组,纳入对象均接受双能X线吸收骨密度仪测定TBF及局部体脂参数(躯干、上肢、下肢),并记录BMI值,另接受MR IDEAL-IQ序列,得出FF值,比较A、B组及不同程度(轻、中、重)NAFLD患者BMI、体脂相关参数、FF值差异,线性相关分析FF值与体脂、BMI的相关性,并将以上指标纳入自变量非条件Logisistic多因素回归分析与NAFLD发病的关系。结果 A组BMI、TBF、躯干体脂、上肢体脂、下肢体脂及FF值较B组明显升高,差异有统计学意义(P<0.05);随病情程度加重,BMI、TBF、躯干体脂占比、上肢体脂占比、下肢体脂占比及FF呈显著增加趋势(P<0.05);FF与TBF、BMI均呈显著正相关(R~2=0.900、0.590);FF值是NAFLD的独立危险因素(P<0.05)。结论 MR Ideal-IQ序列下FF与TBF、BMI有良好的相关性,需引起临床重视。
Objective To study the correlation of liver fat content and fat fraction(FF)with body fat percentage(TBF)and body mass index(BMI)with nonalcoholic fatty liver disease(NAFLD)by MR and IDEAL-IQ sequences. Methods 86 patients with NAFLD were enrolled in the A group,and 50 healthy subjects in the same period were selected as the B group. Participants underwent dual energy measurement of whole body fat content and body fat parameters of local X-ray absorptiometry(trunk,upper and lower limbs),and recorded for the BMI value,the MR IDEAL-IQ sequences and the FF value. The differences of BMI,body fat related parameters and FF value in patients with A,B group and different degree(B Ultrasound divided into mild,medium and heavy) NAFLD were analyzed by linear correlation analysis,and the correlation between FF value and body fat,BMI was analyzed. The above indexes were included in the independent variables,non conditional logistic regression analysis and the analysis of relationship between NAFLD and nonalcoholic fatty liver disease. Results The BMI,TBF,trunk body fat,upper limb fat,lower limb body fat and FF of group A were significantly higher than those of group B(P<0.05). BMI,TBF and trunk body fat were aggravated with the severity of the disease. The proportion of body fat,upper body fat percentage,lower limb body fat percentage and FF increased significantly(P<0.05);liver fat content was significantly positively correlated with TBF and BMI,R~2=0.900,0.590;FF value was non-alcoholic Independent risk factors for fatty liver(P<0.05). Conclusion MR Ideal-IQ liver fat content measurement FF has a good correlation with body fat and BMI,which needs clinical attention.
Objective To study the correlation of liver fat content and fat fraction(FF)with body fat percentage(TBF)and body mass index(BMI)with nonalcoholic fatty liver disease(NAFLD)by MR and IDEAL-IQ sequences. Methods 86 patients with NAFLD were enrolled in the A group,and 50 healthy subjects in the same period were selected as the B group. Participants underwent dual energy measurement of whole body fat content and body fat parameters of local X-ray absorptiometry(trunk,upper and lower limbs),and recorded for the BMI value,the MR IDEAL-IQ sequences and the FF value. The differences of BMI,body fat related parameters and FF value in patients with A,B group and different degree(B Ultrasound divided into mild,medium and heavy) NAFLD were analyzed by linear correlation analysis,and the correlation between FF value and body fat,BMI was analyzed. The above indexes were included in the independent variables,non conditional logistic regression analysis and the analysis of relationship between NAFLD and nonalcoholic fatty liver disease. Results The BMI,TBF,trunk body fat,upper limb fat,lower limb body fat and FF of group A were significantly higher than those of group B(P<0.05). BMI,TBF and trunk body fat were aggravated with the severity of the disease. The proportion of body fat,upper body fat percentage,lower limb body fat percentage and FF increased significantly(P<0.05);liver fat content was significantly positively correlated with TBF and BMI,R~2=0.900,0.590;FF value was non-alcoholic Independent risk factors for fatty liver(P<0.05). Conclusion MR Ideal-IQ liver fat content measurement FF has a good correlation with body fat and BMI,which needs clinical attention.
引文
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[13]王踉碕,彭屹峰.3.0T MRI IdealIQ序列评价成人肝铁浓度与脂肪分数的相关性[J].中国医学影像技术,2015,31(12):1844-1847.Wang LQ,Peng YF.Correlation study of adult fat fraction and iron concentration with 3.0T MRI IdealIQ sequence[J].Chin JMed Imaging Technol,2015,31(12):1844-1847.
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[15]陈艳丽,张宝,管石侠,等.非酒精性脂肪肝病患者体脂成分及膳食营养素摄入分析[J].安徽医科大学学报,2015,50(3):306-309.Chen YL,Zhang B,Guan SX,et al.Body fat composition and dietary nutrients intake analysis with nonalcoholic fatty liver disease[J].Acta Universitatis Medicinalis Anhui,2015,50(3):306-309.
[16]黄晖明,王人卫,李森,等.体重指数与体脂率指标评价肥胖:基于诊断试验的比较研究[J].中国运动医学杂志,2017,36(3):218-225.Huang HM,Wang RW,Li S,et al.Relationship between body mass index and percent body fat in the diagnosis of obesity:based on diagnostic tests[J].Chin J Sports Med,2017,36(3):218-225.
[17]胡强,江朝强,张维森,等.广州市中老年人体脂率与常规肥胖指标相关性及其对应值的研究[J].中华流行病学杂志,2016,37(10):1341-1344.Hu Q,Jiang CQ,Zhang WS,et al.Correlation between body fat rate and routine obesity index and its corresponding value in middle and old aged population in Guangzhou[J].Chinese Journal of Epidemiology,2016,37(10):1341-1344.
[2]范建高.非酒精性脂肪性肝病进展--非酒精性脂肪性肝病的流行率[J].中国医师进修杂志:内科版,2006,29(9):1-2.Fan JG.Progress in nonalcoholic fatty liver disease--Prevalence of nonalcoholic fatty liver disease[J].Chin JPostgrad Med,2006,29(9):1-2.
[3]黄惠强,邓燕君,刘新霞.miR-122在非酒精性脂肪肝病中的诊断价值[J].热带医学杂志,2017,17(2):201-204.Huang HQ,Deng YJ,Liu XX.Expression and clinical significance of miR-122 in nonalcoholic fatty liver disease(NAFLD)[J].J Trop Med,2017,17(2):201-204.
[4]代东伶.儿童非酒精性脂肪肝最新研究动态[J].中国当代儿科杂志,2015,17(1):107-112.Dai DL.Research advances in pediatric nonalcoholic fatty liver disease[J].Chin J Contemp Pediatr,2015,17(1):107-112.
[5]焦志云,李澄,何玲,等.磁共振IDEAL-IQ技术定量评价针灸治疗非酒精性脂肪肝疗效的研究[J].中国医师杂志,2017,19(2):246-249.Jiao ZY,Li C,He L,et al.Therapeutic evaluation of acupuncture in treatment of nonalcoholic fatty liver by magnetic resonance IDEAL-IQ technique[J].Journal of Chinese Physician,2017,19(2):246-249.
[6]秦青,周冬生,梁志清.IL-18与非酒精性脂肪肝的研究进展[J].热带医学杂志,2012,12(10):1297-1299.Qin Q,Zhou DS,Liang ZQ.Research progress of IL-18 and nonalcoholic fatty liver[J].J Trop Med,2012,12(10):1297-1299.
[7]金春花,范能光,张文,等.2型糖尿病患者合并非酒精性脂肪肝与胰岛素抵抗的相关性[J].热带医学杂志,2011,11(1):65-67,73.Jin CH,Fan NG,Zhang W,et al.Non-alcoholic fatty liver disease in patients with type 2 diabetes is closely associated with insulin resistance[J].J Trop Med,2011,11(1):65-67,73.
[8]杨秀珍,耿爱文,肖丽,等.慢性乙型肝炎合并脂肪肝临床与肝组织病理学分析[J].实用肝脏病杂志,2017,20(1):101-102.Yang XZ,Geng AW,Xiao L,et al.Pathological and clinical features of patients with chronic hepatitis B and non-alcoholic fatty liver disease[J].J Prac Hepatol,2017,20(1):101-102.
[9]刘敬.血脂与血糖及肝功能检测对非酒精性脂肪肝患者临床意义探讨[J].中国医药导刊,2016,18(1):3-4.Liu J.Clinical significance of the detection of glucose,lipids and liver function in patients with non alcoholic fatty liver disease[J].Chinese Journal of Medicinal Guide,2016,18(1):3-4.
[10]戴敏方,龚霞蓉,王波,等.3.0T MRI IDEAL序列显示正常臂丛神经节后段的可行性研究[J].中国临床医学影像杂志,2012,23(4):291-293.Dai MF,Gong XR,Wang B,et al.The feasibility of displaying brachial plexus by IDEAL sequence in 3.0T MRI[J].J Chin Clin Med Imaging,2012,23(4):291-293.
[11]黄敏华,郭勇,郑奎宏,等.IDEAL序列在脊柱脂肪抑制中的应用[J].中国医学影像学杂志,2012,20(1):2-4.Huang MH,Guo Y,Zheng QH,et al.Application of spine fat suppression using IDEAL[J].Chinese Journal of Medical Imaging,2012,20(1):2-4.
[12]郭若汨,唐文杰,朱叶青,等.磁共振IDEAL-IQ序列对肝脏脂肪变性和铁过载的诊断价值[J].中山大学学报:医学科学版,2015,36(5):689-692.Guo RM,Tang WJ,Zhu YQ,et al.Diagnostic value of MRIIDEAL-IQ sequence to hepatic steatosis and hepatic ironoverloaded[J].Journal of Sun Yat-sen University:Medical Sciences,2015,36(5):689-692.
[13]王踉碕,彭屹峰.3.0T MRI IdealIQ序列评价成人肝铁浓度与脂肪分数的相关性[J].中国医学影像技术,2015,31(12):1844-1847.Wang LQ,Peng YF.Correlation study of adult fat fraction and iron concentration with 3.0T MRI IdealIQ sequence[J].Chin JMed Imaging Technol,2015,31(12):1844-1847.
[14]张莉,骆善彩,周小梅,等.四项体脂测量指标与非酒精性脂肪肝的关联性研究[J].中国慢性病预防与控制,2015,23(9):649-652.Zhang L,Luo SC,Zhou XM,et al.A study on association of four physical measurements indexes with non-alcoholic fatty liver disease[J].Chin J Prev Contr Chron Dis,2015,23(9):649-652.
[15]陈艳丽,张宝,管石侠,等.非酒精性脂肪肝病患者体脂成分及膳食营养素摄入分析[J].安徽医科大学学报,2015,50(3):306-309.Chen YL,Zhang B,Guan SX,et al.Body fat composition and dietary nutrients intake analysis with nonalcoholic fatty liver disease[J].Acta Universitatis Medicinalis Anhui,2015,50(3):306-309.
[16]黄晖明,王人卫,李森,等.体重指数与体脂率指标评价肥胖:基于诊断试验的比较研究[J].中国运动医学杂志,2017,36(3):218-225.Huang HM,Wang RW,Li S,et al.Relationship between body mass index and percent body fat in the diagnosis of obesity:based on diagnostic tests[J].Chin J Sports Med,2017,36(3):218-225.
[17]胡强,江朝强,张维森,等.广州市中老年人体脂率与常规肥胖指标相关性及其对应值的研究[J].中华流行病学杂志,2016,37(10):1341-1344.Hu Q,Jiang CQ,Zhang WS,et al.Correlation between body fat rate and routine obesity index and its corresponding value in middle and old aged population in Guangzhou[J].Chinese Journal of Epidemiology,2016,37(10):1341-1344.