无创正压通气救治慢性阻塞性肺疾病并呼吸衰竭的临床探讨
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摘要
目的探讨无创正压通气救治慢性阻塞性肺疾病并呼吸衰竭的临床疗效。方法选取134例于2015年1月至2018年10月在本院进行治疗的慢性阻塞性肺疾病并呼吸衰竭患者,依治疗方法不同将其分为对照组和研究组,对照组行常规综合治疗,研究组于对照组基础上加施无创正压通气治疗,观察并比较两组患者的治疗效果。结果两组患者治疗前的pH、PaCO2及PaO2水平比较差异无统计学意义,治疗后均有所改善,研究组治疗后各项动脉血气指标均明显优于对照组,组间比较差异有统计学意义(P<0.05);研究组患者治疗总有效率为89.55%,明显高于对照组73.13%,组间比较差异有统计学意义(P<0.05);经为期6个月的随访,研究组患者不良事件的发生率为14.93%,明显低于对照组的31.34%,组间比较差异有统计学意义(P<0.05)。结论给予慢性阻塞性肺疾病并呼吸衰竭患者无创正压通气治疗可有效纠正患者动脉血气指标,提高治疗效果,减少不良事件的发生,值得在临床当中推广应用。
Objective To investigate the clinical efficacy of noninvasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease with respiratory failure. Methods A total of 134 patients with chronic obstructive pulmonary disease and respiratory failure who were treated in our hospital from January 2015 to October 2018 were enrolled. The patients were divided into the control group and the study group according to different treatment methods. The study group was treated with noninvasive positive pressure ventilation on the basis of the control group, and the therapeutic effects of the two groups were observed and compared. Results There was no significant difference in pH, PaCO2 and PaO2 levels between the two groups before treatment. All the patients were improved after treatment. The arterial blood gas indexes of the study group were significantly better than the control group(P<0.05); the total effective rate of the study group was 89.55%, which was significantly higher than that of the control group(73.13%). There was significant difference between the two groups(P<0.05). After 6 months follow-up, the study group The incidence of adverse events was 14.93%, which was significantly lower than that of the control group(31.34%). There was significant difference between the two groups(P<0.05). Conclusion Non-invasive positive pressure ventilation in patients with chronic obstructive pulmonary disease and respiratory failure can effectively correct the arterial blood gas index, improve the treatment effect and reduce the occurrence of adverse events. It is worthy of popularization and application in clinical practice.
Objective To investigate the clinical efficacy of noninvasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease with respiratory failure. Methods A total of 134 patients with chronic obstructive pulmonary disease and respiratory failure who were treated in our hospital from January 2015 to October 2018 were enrolled. The patients were divided into the control group and the study group according to different treatment methods. The study group was treated with noninvasive positive pressure ventilation on the basis of the control group, and the therapeutic effects of the two groups were observed and compared. Results There was no significant difference in pH, PaCO2 and PaO2 levels between the two groups before treatment. All the patients were improved after treatment. The arterial blood gas indexes of the study group were significantly better than the control group(P<0.05); the total effective rate of the study group was 89.55%, which was significantly higher than that of the control group(73.13%). There was significant difference between the two groups(P<0.05). After 6 months follow-up, the study group The incidence of adverse events was 14.93%, which was significantly lower than that of the control group(31.34%). There was significant difference between the two groups(P<0.05). Conclusion Non-invasive positive pressure ventilation in patients with chronic obstructive pulmonary disease and respiratory failure can effectively correct the arterial blood gas index, improve the treatment effect and reduce the occurrence of adverse events. It is worthy of popularization and application in clinical practice.
引文
[1]李志军,杜娟琳,马增光.无创正压通气治疗慢性阻塞性肺疾病急性加重期合并呼吸衰竭300例效果观察并文献复习[J].临床合理用药杂志,2017,10(20):173-174.
[2]黄楚丽.无创正压通气治疗COPD急性加重合并重度Ⅱ型呼吸衰竭的疗效观察[J].中国现代医生,2014,52(26):133-135.
[3]薛志丽,赵晔,苏芳,等.无创正压通气治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床效果[J].现代生物医学进展,2016,16(25):4929-4931.
[4]周明.无创正压通气对慢性阻塞性肺疾病合并呼吸衰竭的临床疗效[J].国际医药卫生导报,2015,21(3):337-338.
[5]贾保民.无创正压通气在高龄重度呼吸性酸中毒患者治疗中的应用价值探讨[J].当代医学,2016,22(12):42-43.
[6]田光.无创正压通气治疗慢性阻塞性肺疾病并呼吸衰竭疗效评价[J].中国现代医生,2015,53(2):30-32.
[7]黄山桂.无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的临床效果观察[J].临床合理用药杂志,2015,8(12):90-91.
[8]饶明清.无创正压通气治疗慢性阻塞性肺疾病并呼吸衰竭的临床观察[J].现代诊断与治疗,2014,25(20):4602-4603.
[9]刘美红,徐咏梅.无创正压通气对救治慢性阻塞性肺疾病合并呼吸衰竭的临床价值[J].中国实用医药,2015,10(5):113-115.
[10]刘艳红.无创正压通气救治高龄重度呼吸性酸中毒患者的临床疗效评价[J].中国临床研究,2014,40(1):52-54.
[2]黄楚丽.无创正压通气治疗COPD急性加重合并重度Ⅱ型呼吸衰竭的疗效观察[J].中国现代医生,2014,52(26):133-135.
[3]薛志丽,赵晔,苏芳,等.无创正压通气治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床效果[J].现代生物医学进展,2016,16(25):4929-4931.
[4]周明.无创正压通气对慢性阻塞性肺疾病合并呼吸衰竭的临床疗效[J].国际医药卫生导报,2015,21(3):337-338.
[5]贾保民.无创正压通气在高龄重度呼吸性酸中毒患者治疗中的应用价值探讨[J].当代医学,2016,22(12):42-43.
[6]田光.无创正压通气治疗慢性阻塞性肺疾病并呼吸衰竭疗效评价[J].中国现代医生,2015,53(2):30-32.
[7]黄山桂.无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的临床效果观察[J].临床合理用药杂志,2015,8(12):90-91.
[8]饶明清.无创正压通气治疗慢性阻塞性肺疾病并呼吸衰竭的临床观察[J].现代诊断与治疗,2014,25(20):4602-4603.
[9]刘美红,徐咏梅.无创正压通气对救治慢性阻塞性肺疾病合并呼吸衰竭的临床价值[J].中国实用医药,2015,10(5):113-115.
[10]刘艳红.无创正压通气救治高龄重度呼吸性酸中毒患者的临床疗效评价[J].中国临床研究,2014,40(1):52-54.